HHV-8 prevalence, immunosuppression and Kaposi's sarcoma in south Italy

Crispo, Anna; Tamburini, Mario; Marco, M R De; Ascierto, Paolo A.; Silvestro, P; Ronga, Domenico; Tridente, Vincenzo; Desicato, Sonia; Carbone, Stefano; Fabbrocini, Gabriella; Spiteri, D.; Montella, Maurizio

doi:10.3892/ijmm.7.5.535

Cited by 12 publications

(12 citation statements)

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“…45 The prevalence rates of lytic and latent HHV-8 antigens were 20% and 15%, respectively, in hospitalized patients in southern Italy. 67 Although sexual transmission is important, especially among homosexuals, nonsexual transference also occurs. HHV-8 may replicate in the tonsils and be shed in saliva.…”

Section: Hhv-8 Virusmentioning

confidence: 99%

Kaposi sarcoma: A continuing conundrum

Schwartz

Micali

Nasca

et al. 2008

Journal of the American Academy of Dermatology

203

212

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Section: Hhv-8 Virusmentioning

confidence: 99%

Kaposi sarcoma: A continuing conundrum

Schwartz

Micali

Nasca

et al. 2008

Journal of the American Academy of Dermatology

203

212

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“…In particular, higher seroprevalence rates of HHV-8 are reported in Southern Italy compared to Northern Italy, Spain, and Israel [Calabro et al, 1998;Weiss et al, 1998;Iscovich et al, 2000;Perna et al, 2000;Crispo et al, 2001;Gambus et al, 2001]. Nevertheless, recent epidemiologic study conducted in Eastern Sicily indicated that HHV-8 prevalence in blood donors is relatively low (2.4%) [Larocca et al, 2005].…”

Section: Introductionmentioning

confidence: 99%

Human herpesvirus 8 (HHV‐8) infection in healthy urban employees from Greece: Seroprevalence and associated factors

Sypsa¹,

Petrodaskalaki²,

Kalapothaki³

et al. 2007

Journal of Medical Virology

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A cross-sectional study was carried out in healthy company employees from Greece with the aim of assessing the prevalence of human herpesvirus 8 (HHV-8) and identifying risk factors for this herpesviral infection. Serum samples obtained from 955 subjects were tested for antibodies to HHV-8 by the K8.1 enzyme-linked immunosorbent assay (ELISA). Associations between HHV-8 serostatus and potential risk factors were examined using t-test, chi square test, and multivariate logistic regression analysis. HHV-8 prevalence was 7.6% (95% confidence interval (CI): 6.0%, 9.5%) and it increased with age from 6.5% among <30 years old to 13.8% among > or =50 years old subjects (P = 0.006). HHV-8 seropositivity was independently associated with endoscopic examination (odds ratio (OR): 2.01; 95% CI: 1.09, 3.70; P = 0.026), HBsAg positivity (OR: 5.16; 95% CI: 2.02, 13.20; P = 0.001) and age (OR > or =50 years old vs. <50 years old: 2.09; 95% CI: 1.23, 3.52; P = 0.006). No statistically significant associations between HHV-8 positive status and gender, occupational status, surgery, transfusion, tattoos/body piercing, multiple sex partners, weakness/fatigue, HCV status were observed. HHV-8 is prevalent in Greece. The strong association between HBV infection and HHV-8 positive status supports the hypothesis of an association between these two viral infections. The association between HHV-8 seropositivity and endoscopic examination requires further investigation.

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“…Ce virus a été associé au sarcome de Kaposi, raison pour laquelle il est également appelé le virus de l'herpès associé au sarcome de Kaposi. Une forte prévalence de diabète a été rapportée chez des patients atteints de sarcome de Kaposi quelle que soit leur origine géo-graphique [9]. Nous avons donc réalisé une étude pour tester l'hypothèse a priori selon laquelle l'infection par le virus HHV-8 pourrait être un facteur participant au déficit transitoire de l'insulinosécrétion.…”

Section: L'herpès Virus Humain De Type 8 (Hhv-8)unclassified

Diabète de type 2 cétonurique et virus de l’herpès humain de type 8

Gautier

2008

Med Sci (Paris)

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HHV-8 prevalence, immunosuppression and Kaposi's sarcoma in south Italy

Cited by 12 publications

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Kaposi sarcoma: A continuing conundrum

Kaposi sarcoma: A continuing conundrum

Human herpesvirus 8 (HHV‐8) infection in healthy urban employees from Greece: Seroprevalence and associated factors

Diabète de type 2 cétonurique et virus de l’herpès humain de type 8

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