Hibernating bear serum hinders osteoclastogenesis in-vitro

Nasoori, Alireza; Okamatsu‐Ogura, Yuko; Shimozuru, Michito; Sashika, Mariko; Tsubota, Toshio

doi:10.1371/journal.pone.0238132

Cited by 7 publications

(3 citation statements)

References 64 publications

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“…Therefore, osteological and osteoimmunological research has successfully been performed on a large range of vertebrate species/taxa from teleost fish up to a large number of domesticated mammal species. Besides, also wildlife species are attracting scientific interest to an increasing degree, as some of these, such as bears, have developed sophisticated mechanisms to avoid suffering from pathological conditions such as osteoporosis in situations, other species would not be able to cope with [7][8][9].…”

Section: First Publications On Rankl Activated T-cells Stimulate Osteoclastogenesismentioning

confidence: 99%

Evolution and History of Osteoimmunology

et al. 2021

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This narrative review focuses on the evolution and history of osteoimmunology, which is a research field that investigates the interactions between bone and components of the immune system. Looking at the evolution of bone, bone development dates back approximately 540 million years. Osteoimmune aspects can also be found in different bone-related diseases like osteoporosis, which is a frequent age-related disease and was first recognized in 1751. Moreover, rheumatoid arthritis is known as the prototype of an osteoimmune disease, which was first clinically described in 1800. A further important component of this field are osteoclasts, a term that was coined by Kölliker in 1873. For the treatment of osteoporosis different therapeutic options are available, among which 2 antibodies (denosumab and romosozumab) were currently approved by the European Medicines Agency in 2010 and 2019, respectively, thus showing the importance of osteoimmunological research for patients’ sake.

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Section: First Publications On Rankl Activated T-cells Stimulate Osteoclastogenesismentioning

confidence: 99%

Evolution and History of Osteoimmunology

et al. 2021

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“…Significant (FDR < 0.001) down-regulation of the two caspase genes (CASP3, FC = − 3.43 and CASP7, FC = − 3.77) is consistent with decline in caspase 3/7 activity detected in MC3T3-E1 osteoblast culture treated with hibernaton serum compared to serum from physically active black bears 42 . Furthermore, peripheral blood mononuclear cells treated with summer bear serum promoted the formation of multinuclear cells and high TRACP activity 43 . In contrast, hibernating bear serum failed to promote the formation of multinuclear cells and TRACP activity was more than tenfold lower compared to treatment with summer serum.…”

Section: Discussionmentioning

confidence: 95%

Transcriptional changes and preservation of bone mass in hibernating black bears

Goropashnaya

Tøien

Ramaraj

et al. 2021

Sci Rep

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Physical inactivity leads to losses of bone mass and strength in most mammalian species. In contrast, hibernating bears show no bone loss over the prolonged periods (4–6 months) of immobility during winter, which suggests that they have adaptive mechanisms to preserve bone mass. To identify transcriptional changes that underlie molecular mechanisms preventing disuse osteoporosis, we conducted a large-scale gene expression screening in the trabecular bone and bone marrow, comparing hibernating and summer active bears through sequencing of the transcriptome. Gene set enrichment analysis showed a coordinated down-regulation of genes involved in bone resorption, osteoclast differentiation and signaling, and apoptosis during hibernation. These findings are consistent with previous histological findings and likely contribute to the preservation of bone during the immobility of hibernation. In contrast, no significant enrichment indicating directional changes in gene expression was detected in the gene sets of bone formation and osteoblast signaling in hibernating bears. Additionally, we revealed significant and coordinated transcriptional induction of gene sets involved in aerobic energy production including fatty acid beta oxidation, tricarboxylic acid cycle, oxidative phosphorylation, and mitochondrial metabolism. Mitochondrial oxidation was likely up-regulated by transcriptionally induced AMPK/PGC1α pathway, an upstream stimulator of mitochondrial function.

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“…Japanese scholars used macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-B ligand (RANKL) to induce differentiation of peripheral blood mononuclear cells (PBMCs) to OBs in hibernating black bear serum. It was found that the conversion of PBMCs to OBs was inhibited [39] .…”

Section: Cold Stimulation On the Skeletonmentioning

confidence: 99%

Advances in the research field of osteoporosis in cold areas

Zhou

Zhang

Nie

et al. 2022

Frigid Zone Medicine

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While osteoporosis is a chronic disease caused by multiple factors, it is also a risk factor for fractures. At present, numerous risk factors for osteoporosis and secondary fractures have been identified, including sunlight, physical fitness, gender, age, trauma, dietary habits, tobacco, alcohol, drugs, air quality, and genetics. Despite that factors such as long winters, short daylight hours, less daily physical activity, air pollution, low calcium and high salt diet, and sedentary lifestyle could negatively impact the bones of residents in the alpine regions of northern China, the direct effect of low-temperature stimulation on bone growth and development remains unclear. In this study, by reviewing current research progress related to osteoporosis and fracture risk in northern China, we proposed appropriate preventive measures for different risk factors to reduce the occurrence of osteoporosis and fracture in cold areas of northern China.

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Hibernating bear serum hinders osteoclastogenesis in-vitro

Cited by 7 publications

References 64 publications

Evolution and History of Osteoimmunology

Evolution and History of Osteoimmunology

Transcriptional changes and preservation of bone mass in hibernating black bears

Advances in the research field of osteoporosis in cold areas

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