Hibiscus sabdariffa extractivities on cadmium—mediated alterations of human U937 cell viability and activation

Abstract

The findings show that H. sabdariffa possesses significant immunoprotective effect. These corroborate the immense reported antioxidant and medicinal potential of the calyces of the plant which could be exploited for pharmacological and neutraceutical advantages.

Cytoprotective effects of dietary flavonoids against cadmium‐induced toxicity

“…found that catechin hydrate played antigenotoxic and anti‐immunotoxicity protective roles by decreasing DNA fragmentation and inhibiting the expression of genes related to apoptosis. Other studies have shown that flavonoids prevented apoptosis by preventing the formation of the mitochondrial permeability transition pore . Dua et al .…”

“…NF‐κB regulates transcription of some genes . Cd induces DNA breakage of lymphocytes and induces apoptosis of human lymphocytes by upregulating the expression of p53 . In addition, there is ROS‐mediated alteration of transcription levels of signal proteins (viz.…”

“…Okoko et al . found that the anthocyanin‐rich extract of Hibiscus sabdariffa ( H. sabdariffa ) calyx was more efficient than quercetin at increasing the viability of human monocytic U937 cells, via decreasing LPO . Gong et al .…”

“…Studies have showed that flavonoids could inhibit the levels of iNOS and COX‐2, promote the vitality of lymphocytes, increase IL‐4 content, and decrease NO content by directly reacting with NO . Okoko et al . found that anthocyanins reduced the release of TNF‐α, IL‐6, IL‐1, and NO, finally inhibiting the inflammatory effect .…”

“…Okoko et al . found that anthocyanins reduced the release of TNF‐α, IL‐6, IL‐1, and NO, finally inhibiting the inflammatory effect . Hwang et al .…”