Hiccup – A Side-Effect of Pulse Therapy

Kanwar, Amrinder J.; Kaur, Savleen; Dhar, Sandipan; Ghosh, S.

doi:10.1159/000247265

Cited by 14 publications

(9 citation statements)

References 2 publications

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“…The onset of dexamethasone-induced hiccups was reported as early as during the intravenous infusion and as late as 12 h after the last dose [22,23,24,25,26]. Corticosteroid-associated hiccups may persist for hours to days [22,23,24,25,26].…”

Section: Discussionmentioning

confidence: 99%

“…The reported incidence of this complication varies between 3% and 61% [10,11,12,13,14,15,16,17,18]. Gralla [17] mentions that hiccups are probably due to corticosteroid medication, but hiccups are an uncommon adverse effect of high-dose corticosteroid administration and only a few cases of dexamethasone-induced hiccups have been reported in the literature [19,20,21,22,23,24,25,26]. The mechanism of corticosteroid-associated hiccups is not known.…”

Section: Introductionmentioning

confidence: 99%

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Gender discrepancy observed between chemotherapy-induced emesis and hiccups

Liaw

Wang²,

Chang³

et al. 2001

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The aim of this paper was to describe striking gender differences observed between emesis and hiccups in patients receiving cisplatin-based chemotherapy (CT) and one of two dexamethasone-containing anti-emetic regimens. Four hundred patients were evaluated in a crossover study with two arms. Patients in arm A received three doses of ondansetron 8 mg i.v. at 4-h intervals plus dexamethasone 20 mg i.v. from the start of CT, followed by dexamethasone 5 mg i.v. every 12 h, until CT was complete, after which dexamethasone was discontinued. For patients in arm B the treatment was the same as in arm A except that the three doses of ondansetron 8 mg i.v. were given at 24-h intervals. There were 363 patients in arm A and 358 patients in arm B. Vomiting/nausea/hiccups were observed in 30.3%/41.6%/23.7% of patients in arm A and 28.8%/39.1%/23.7% of patients in arm B, respectively. Comparison showed that the rates for complete control of vomiting and nausea on days 1 through 6 were significantly lower in women (P<0.0001 and =0.0004 in arm A and P<0.0001 and <0.0001 in arm B, respectively). Men had a significantly higher incidence of hiccups (P<0.0001 in both arms), but no apparent associations with age, cisplatin dose, tumor type, and the presence of vomiting and nausea during CT were found. Hiccups usually began 24 h after cisplatin administration and persisted for some days. Women had significantly higher rates of vomiting and nausea. The cause of the gender discrepancy is unknown.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gender discrepancy observed between chemotherapy-induced emesis and hiccups

Liaw

Wang²,

Chang³

et al. 2001

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“…Incidentally, flushing and hiccup as the side effects of DCP were first documented by the senior author. [78,79] High-dose intravenous corticosteroid pulse can occasionally lead to cardiac complications that may include arrhythmias, cardiac ischemia, arterial thrombosis due to profound hypercoagulability, and even sudden death. Most of these cardiovascular complications occur within first 24 hours of infusion.…”

Section: Complications Of Treatmentmentioning

confidence: 99%

Pemphigus in India

Kanwar¹,

De²

2011

Indian J Dermatol Venereol Leprol

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Pemphigus is a chronic epidermal immunobullous disease with potentially fatal outcome. The journey of literature on pemphigus in India has come a long way in last five decades. Pemphigus in Indian patients has unique genetic, clinical, and epidemiological differences from those in the Western countries. Corticosteroids remain the mainstay of treatment for pemphigus. Dexamethasone-cyclophosphamide pulse therapy has revolutionized the management of pemphigus in India and abroad for nearly 3 decades now. Corticosteroid-based treatment, along with adjuvants, has significantly brought down the high mortality rates that had been observed in precorticosteroid era. Present day research is largely based on elucidating the pathogenesis beyond the antidesmoglein antibodies, and newer diagnostic and treatment approaches. In this article, we review various aspects of literature on pemphigus in India, on Indians abroad, or literature from other countries that are considered relevant to the topic.

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“…1 Thompson and Landry 1 recently reviewed case reports of druginduced hiccups, noticing that IV corticosteroids, especially dexamethasone, and benzodiazepines are the drug classes most frequently associated with the development of hiccups. To our knowledge, there have been 5 reports of dexamethasone-associated hiccups (5 patients), 2-6 1 report of dexamethasone-cyclophosphamide-associated hiccups (4 patients), 7 2 reports of MTP-associated hiccups (total 4 patients), 8,9 1 report of triamcinolone-associated hiccups, 9 and 2 reports of betamethasoneassociated hiccups (2 patients) 9,10 in the medical literature (Table 2). Interestingly, we have reported the first female patient (included in Table 2) with corticosteroid-associated hiccups, perhaps implying a yet-to-be-elucidated hormonal influence in the mechanism of corticosteroid-associated hiccups.…”

Section: Discussionmentioning

confidence: 99%

“…1 Hiccups associated with corticosteroid therapy have been infrequently reported. [2][3][4][5][6][7][8][9][10] We report a cases series of hiccups associated with intravenous (IV) corticosteroid therapy.…”

mentioning

confidence: 99%

Persistent Hiccups Associated With Intravenous Corticosteroid Therapy

Hung¹,

Miller²,

Patel³

2003

JCR: Journal of Clinical Rheumatology

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Singulata, commonly known as hiccups, have many causes and are most often idiopathic and short-lived. Occasionally, hiccups can be persistent and becoming quite bothersome, distracting, and even disabling. Many medications have been implicated as a cause of hiccups. Although uncommon, corticosteroids and benzodiazepines are 2 classes of drugs most frequently associated with the development of hiccups. The following case series describes 5 patients with intravenous corticosteroid-associated hiccups reported to our adverse drug reaction reporting system between January 1998 and December 2000. Physicians using intravenous corticosteroids should be aware of this potential complication.

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Hiccup – A Side-Effect of Pulse Therapy

Cited by 14 publications

References 2 publications

Gender discrepancy observed between chemotherapy-induced emesis and hiccups

Gender discrepancy observed between chemotherapy-induced emesis and hiccups

Pemphigus in India

Persistent Hiccups Associated With Intravenous Corticosteroid Therapy

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