Hidden Benefits of Honeybee Propolis in Hives

Borba, Renata S.; Wilson, Michael B.; Spivak, Marla

doi:10.1007/978-3-319-60637-8_2

Cited by 9 publications

(3 citation statements)

References 44 publications

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“…On the honey bees turn, resin collection is a difficult and time-consuming process. The proportion of total honey bee laborers collecting resins is less than 1% of the total forager work force (Borba et al 2017). Several kinds of constraints may be pointed out as factors that magnify the burden represented by resin collection by bee laborers and narrow the diversity of plant species candidate as sources of resin for honey bee propolis.…”

Section: Spectrum Width Of Botanical Sources: Constraintsmentioning

confidence: 99%

“…Also, propolis has revealed activity against honey bee parasites, such as the gut infecting microsporidium Nosema ceranae (Mura et al 2020) and the mite Varroa infestans (Pusceddu et al 2018). The use of plant resins by honey bees has been characterized as a self-medication process, by which propolis substances, on one side, exert detrimental effects on parasites and, on the other side, increase bee fitness and the social immunity of the hive (Simone-Finstrom et al 2012;Borba et al 2017;Pusceddu et al 2018).…”

Section: Functional Constraintsmentioning

confidence: 99%

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How diverse is the chemistry and plant origin of Brazilian propolis?

Salatino

Negri

2021

Apidologie

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Propolis is a honey bee product containing chiefly beeswax and resins originated from plant buds or exudates. Propolis resin exerts a diversity of biological activities, such as antitumoral, anti-inflammatory, antimicrobial, and defense of the hive against pathogens. Chemical standardization and identification of botanical sources is crucial for characterization of propolis. Types of Brazilian propolis are characteristic of geographical regions and respective biomes, such as savannas (Cerrado), mangroves, dry forest (Caatinga), rain forests (Amazon, Atlantic, and Interior forests), altitudinal fields ("Campos Rupestres"), Pantanal, and Araucaria forests. Despite the wide diversity of Brazilian biomes and flora, relatively few types of Brazilian propolis and corresponding resin plant sources have been reported. Factors accounting for the restricted number of known types of Brazilian propolis and plant sources are tentatively pointed out. Among them, the paper discusses constraints that honey bees must overcome to collect plant exudates, including the characteristics of the lappingchewing mouthpart of honey bee, which limit their possibilities to cut and chew plant tissues, as well as chemical requirements that plant resins must fulfil, involving antimicrobial activity of its constituents and innocuity to the insects. Although much still needs to be done toward a more comprehensive picture of Brazilian propolis types and corresponding plant origins, the prospects indicate that the actual diversity of plant sources of honey bee propolis will remain relatively low.

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Section: Spectrum Width Of Botanical Sources: Constraintsmentioning

confidence: 99%

Section: Functional Constraintsmentioning

confidence: 99%

How diverse is the chemistry and plant origin of Brazilian propolis?

Salatino

Negri

2021

Apidologie

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“…Propolis is a large mixture of polyphenols, essential oils, and waxes produced by plants as resinous secretions. This is collected by honeybees, which use it as a waterproof substance to seal hive cracks or holes [ 12 ]. Furthermore, bees use propolis as an antiseptic material to prevent infections due to its powerful antibacterial [ 13 ] and antiparasitic properties [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities

Pérez,

Burgos,

Marín

et al. 2023

Antioxidants

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Neurodegenerative disorders are characterized by a progressive process of degeneration and neuronal death, where oxidative stress and neuroinflammation are key factors that contribute to the progression of these diseases. Therefore, two major pathways involved in these pathologies have been proposed as relevant therapeutic targets: The nuclear transcription factor erythroid 2 (Nrf2), which responds to oxidative stress with cytoprotecting activity; and the nuclear factor NF-κB pathway, which is highly related to the neuroinflammatory process by promoting cytokine expression. Caffeic acid phenethyl ester (CAPE) is a phenylpropanoid naturally found in propolis that shows important biological activities, including neuroprotective activity by modulating the Nrf2 and NF-κB pathways, promoting antioxidant enzyme expression and inhibition of proinflammatory cytokine expression. Its simple chemical structure has inspired the synthesis of many derivatives, with aliphatic and/or aromatic moieties, some of which have improved the biological properties. Moreover, new drug delivery systems increase the bioavailability of these compounds in vivo, allowing its transcytosis through the blood-brain barrier, thus protecting brain cells from the increased inflammatory status associated to neurodegenerative and psychiatric disorders. This review summarizes the biosynthesis and chemical synthesis of CAPE derivatives, their miscellaneous activities, and relevant studies (from 2010 to 2023), addressing their neuroprotective activity in vitro and in vivo.

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What We Learned as Editors

Vreeland¹,

Sammataro

2017

Beekeeping – From Science to Practice

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Hidden Benefits of Honeybee Propolis in Hives

Cited by 9 publications

References 44 publications

How diverse is the chemistry and plant origin of Brazilian propolis?

How diverse is the chemistry and plant origin of Brazilian propolis?

Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities

What We Learned as Editors

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