Hidradenitis suppurativa in a transgender man

Ramos‐Rodríguez, Daniel; Garcías-Ladaria, J.; Soler, Guillermo Serra; Martín‐Santiago, A.

doi:10.1111/ced.14680

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…Mortimer et al discovered early on that female HS patients have an elevated testosterone and free androgen index [ 17 ]. There are three cases reported where cross-sex hormone therapy (CSHT) with testosterone resulted in an exacerbation or manifestation of HS [ 18 , 19 ]. In contrast to the above results, Harrison reports that there is no difference in testosterone between HS and healthy controls [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

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The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review

Rached

Gambichler

Dietrich

et al. 2022

IJMS

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Hidradenitis suppurativa (HS) is a chronic inflammatory disease manifesting in inverse body regions. In a systematic review, the role of hormones in HS will be presented to better understand the pathomechanisms of HS. The review is based on the PRISMA criteria. Systematic research was carried out using keywords. Subsequently, the data were analyzed based on the clinical response and other relevant information. The main focus of our systematic review was on HS manifestation, exacerbation, sex hormones, antiandrogen therapy, thyroid function, polycystic ovary syndrome, insulin resistance, and adipokines. In HS, there appears to be a dysregulated adipokine release that is shifted towards pro-inflammatory adipokines. Insulin resistance is significantly more common in HS than in healthy patients regardless of BMI, age, and gender. Insulin resistance in HS patients leads to further cardiovascular disease. The mechanism of insulin resistance and role of adipokines should be investigated in future studies to better provide the pathomechanisms of HS. The role of androgens seems to be important in a certain subgroup of female patients. Anti-androgenic therapy can be useful and helpful in some patients. However, further studies are needed to better understand the hormonal relationship in HS.

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Section: Resultsmentioning

confidence: 99%

“…However, this connection has not yet been proven. A subdivision between hormone-dependent and hormone-dependent HS could be interesting in the future to provide further information, as well as that cross-sex hormone therapy worsens HS, showing that androgens should be considered in HS pathogenesis [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review

Rached

Gambichler

Dietrich

et al. 2022

IJMS

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“…Recently, Gomez et al, in a review article, provided the reader with the key evidence and recommendations for caring for SGMs with HS [ 23 ]. In this context, the management of HS in transgender individuals may be even more challenging, as masculinizing hormone therapy might worsen HS lesions [ 24 , 25 ].…”

Section: Hs and Gendermentioning

confidence: 99%

Hidradenitis Suppurativa: The Influence of Gender, the Importance of Trigger Factors and the Implications for Patient Habits

et al. 2022

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Hidradenitis suppurativa (HS) is a debilitating, chronic, inflammatory skin disease primarily affecting apocrine gland-rich areas of the body. On the one hand, the presence of triggering factors—some identified, others only hypothesized—may initiate or perpetuate the pathogenic process of HS. In addition to cigarette smoking and diet, other trigger factors, including choice of clothing, are frequently observed in clinical practice. On the other hand, the presence of disease may influence habits of HS patients. Indeed, high incidences of sexual and sleep impairment have been reported in these patients. Consequently, alcohol and substance abuse may be a coping strategy for the emotional and psychological disease burden. Furthermore, a greater awareness of gender differences in HS may be important for dermatologists in their own clinical practice (i.e., pregnancy and breastfeeding). Consequently, in this loop interaction, comprehensive knowledge of all factors involved is crucial for the management of HS patients. Thus, the objective of this review is to (i) discuss the influence of gender on HS, (ii) summarize the most frequent triggering factors of HS and (iii) analyze the impact of HS on patient habits.

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“… 3 There are only 3 published cases of exogenous testosterone (ET) in association with either new-onset HS or exacerbation of existing HS. 4 , 5 Here, we conduct a cross-sectional evaluation of the risk of HS exacerbation within 6 months of initiating ET therapy in patients with preexisting HS diagnosis.…”

mentioning

confidence: 99%

Lack of association of exogenous testosterone administration with exacerbation of preexisting hidradenitis suppurativa

Kamal,

Afzal,

Ziad

et al. 2024

JAAD International

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Hidradenitis suppurativa in a transgender man

Cited by 5 publications

References 9 publications

The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review

The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review

Hidradenitis Suppurativa: The Influence of Gender, the Importance of Trigger Factors and the Implications for Patient Habits

Lack of association of exogenous testosterone administration with exacerbation of preexisting hidradenitis suppurativa

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