Hidradenitis suppurativa: Morphologic and vascular study of nodular inflammatory lesions by means of optical coherence tomography

Manfredini, Marco; Chello, Camilla; Ciardo, Silvana; Guida, Stefania; Chester, Johanna; Lasagni, Claudia; Bigi, Laura; Farnetani, Francesca; Bettoli, Vincenzo; Pellacani, Giovanni

doi:10.1111/exd.14560

Cited by 9 publications

(18 citation statements)

References 37 publications

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“…OCT is a well-established noninvasive diagnostic device, with a lateral resolution in the 3–15 µm range and a penetration depth of 1–2 mm. Dynamic OCT (D-OCT) allows the visualization of the epidermis and dermis and of the relative microvascular changes in blood flow, in order to allow the morphological and functional characterization of skin lesions [ 20 , 21 , 22 ].…”

Section: Oct In Acne Lesionsmentioning

confidence: 99%

Dermoscopy, Reflectance Confocal Microscopy and Optical Coherence Tomography Features of Acne: A Systematic Review

Alma

Sticchi

Chello

et al. 2022

JCM

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Noninvasive imaging techniques have recently outlined precise microscopic features of acne elementary lesions and accurate quantifications for disease severity staging and therapeutical efficacy follow-up. The aim of this review is to systematically describe current applications of dermoscopy, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT) in acne vulgaris assessment and management. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. We included studies conducted on human subjects with elementary lesions of acne vulgaris, reporting assessment of the lesions with dermoscopy, RCM, and/or OCT. At present there are few large studies regarding acne and noninvasive imaging techniques, representing the main limitation of this review. Clinical examination represents the first line in acne diagnosis and treatment. However, dermoscopy, RCM, and OCT are further tools that can improve acne classification, monitoring of treatment, and pathophysiologic characterization. In the near future, dermoscopy, RCM, and OCT could become routinely used for the evaluation of acne vulgaris to provide a deeper knowledge of the disease and to guide the clinician in the prescription of tailored treatment protocols based on each patient’s characteristics.

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Section: Oct In Acne Lesionsmentioning

confidence: 99%

Dermoscopy, Reflectance Confocal Microscopy and Optical Coherence Tomography Features of Acne: A Systematic Review

Alma

Sticchi

Chello

et al. 2022

JCM

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“…The 39 studies included concerned the following 10 skin diseases: 14 studies of acne vulgaris, [7][8][9][10][11][12][13][14][15][16][17][18][19][20] nine studies of rosacea, [21][22][23][24][25][26][27][28] four studies of alopecia areata, [30][31][32][33] two studies of HS, 35,41 two studies of folliculitis, 34,42 two studies of folliculitis decalvans, 43,44 two studies of lichen planopilaris, 33,45 two studies of discoid lupus erythemasus, 33,46 one study of frontal fibrosing alopecia 47 and one including one patient with keratosis pilaris. 48 In total, 33 RCM studies, 12 OCT studies and 45 combined.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…34 OCT visualizes cross-sectional details of skin layers and hairs to a depth of 1-2 mm and has previously been used to explore acne vulgaris, 7,14,[16][17][18] rosacea 29 and HS. 35 Keratin and fibrosis are hyperreflective and appear bright in OCT images. 34 Inflammatory cells, melanocytes, erythrocytes, stroma and keratin appear bright in RCM images.…”

Section: Introductionmentioning

confidence: 99%

Confocal microscopy and optical coherence tomography of inflammatory skin diseases in hairs and pilosebaceous units: A systematic review

Al-Chaer

Bouazzi

Jemec

et al. 2023

Experimental Dermatology

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Common skin disorders such as acne vulgaris, rosacea and folliculitis are bothersome prevalent inflammatory diseases of hair follicles that can easily be investigated bedside using optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) with micrometre resolution, opening a novel era for high‐resolution hair follicle diagnostics and quantitative treatment evaluation. EMBASE, PubMed and Web of Science were searched until 5 January 2023 to identify all studies imaging hair follicle characteristics by RCM and OCT for diagnosis and monitoring of treatment in hair follicle‐based skin disorders. This study followed PRISMA guidelines. After inclusion of articles, methodological quality was assessed using the QUADAS‐2 critical appraisal checklist. Thirty‐nine in vivo studies (33 RCM and 12 OCT studies) were included. The studies focused on acne vulgaris, rosacea, alopecia areata, hidradenitis suppurativa, folliculitis, folliculitis decalvans, lichen planopilaris, discoid lupus erythemasus, frontal fibrosing alopecia and keratosis pilaris. Inter‐ and perifollicular morphology including number of demodex mites, hyperkeratinization, inflammation and vascular morphology could be assessed by RCM and OCT in all included skin disorders. Methodological study quality was low, and interstudy outcome variability was high. Quality assessment showed high or unclear risk of bias in 36 studies. Both RCM and OCT visualize quantitative features as size, shape, content and abnormalities of hair follicles, and have potential to support clinical diagnosis and evaluate treatment effects. However, larger studies with better methodological quality are needed to implement RCM and OCT directly into clinical practice.

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confidence: 99%

“…Hidradenitis suppurativa (HS) is a multifactorial disease characterized by the progression of nodules to deep-seated lesions, with subsequent scarring and suppuration. [1][2][3][4] The exact etiology of HS is still unproven.…”

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confidence: 99%

Topical finasteride: A potential therapeutic option for hidradenitis suppurativa

Manfredini

Alma

Pongetti

et al. 2022

Dermatologic Therapy

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Hidradenitis suppurativa (HS) is a multifactorial disease characterized by the progression of nodules to deep-seated lesions, with subsequent scarring and suppuration. [1][2][3][4] The exact etiology of HS is still unproven.Multiple therapies have been described, including topical, systemic, surgical, and physical treatments. 1,5,6 At present, topical HS therapy include cleansers, keratolytic agents, and antibiotics. 7 Androgens are implicated in skin physiology and may have a role in HS worsening. 8 Consequently, the administration of systemic antiandrogen therapy were described in a small population. 5,8 To the best of our knowledge, this is the first study that describes topical antiandrogen therapy in HS. Here we describe 4 patients that received a commercially available topical finasteride on 2-3 HS affected sites at dosage 50 μl of 2275 mg/ml for each area (Table 1). Patients did not alter their hygiene or antiseptic habits during topical finasteride application.Case 1: A 28-year-old man affected by HS for 12 years, with lesions in axillae, gluteal and inguinal region. He received multiple HS treatments with disease recurrence and discontinuation (Table 1).Recently he experienced frequent inflammatory episodes of three nodules in the left axilla and one nodule in the right axilla. Disease severity 1,9 was: Hurley II, international HS severity (IHS4): 6, dermatology life quality index (DLQI): 16. Daily topical finasteride was introduced on both axillae. Three months later, a significant improvement was observed (IHS4: 2, DLQI: 8, Figure 1A-D).

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Hidradenitis suppurativa: Morphologic and vascular study of nodular inflammatory lesions by means of optical coherence tomography

Cited by 9 publications

References 37 publications

Dermoscopy, Reflectance Confocal Microscopy and Optical Coherence Tomography Features of Acne: A Systematic Review

Dermoscopy, Reflectance Confocal Microscopy and Optical Coherence Tomography Features of Acne: A Systematic Review

Confocal microscopy and optical coherence tomography of inflammatory skin diseases in hairs and pilosebaceous units: A systematic review

Topical finasteride: A potential therapeutic option for hidradenitis suppurativa

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