Hierarchical 0D-2D bio-composite film based on enzyme-loaded polymeric nanoparticles decorating graphene nanosheets as a high-performance bio-sensing platform

Reduced Graphene Oxide-Coated Silica Nanospheres as Flexible Enzymatic Biosensors for Detection of Glucose in Sweat

“…Further, the I D / I G value of GO (1.068) was higher than that of Gr (0.854), which may be caused by the increase of sp 3 hybridization brought about by new functional groups in GO. Figure S1B shows the FT-IR spectrum of GO where the characteristic peaks ascribed to O–H stretching vibration, CO stretching vibration, O–H bending vibration, C–O–C stretching vibration, and C–O stretching vibration are observed at 3375, 1723, 1412, 1224, and 1062 cm –1 , respectively . These peaks are strong evidence for the generation of oxygen-containing functional groups (hydroxyl groups, carbonyl groups, carboxyl groups, and epoxy groups) on the surface or edge of graphene.…”

“…Further, the I D /I G value of GO (1.068) was higher than that of Gr (0.854), which may be caused by the increase of sp 3 hybridization brought about by new functional groups in GO. 33 These peaks are strong evidence for the generation of oxygen-containing functional groups (hydroxyl groups, carbonyl groups, carboxyl groups, and epoxy groups) on the surface or edge of graphene. The morphology of GO was characterized with AFM and TEM as shown in Figure S1C and S1E.…”

Recent progress in the fabrication of flexible materials for wearable sensors

“…At present, many wearable sensors rely on various kinds of electrodes to obtain information regarding the analyte to be tested based on enzymatic reaction or direct detection methods, transmit the obtained information in the form of an electrical signal, and integrate with a signal analysis system to directly obtain the indicators for body detection. 75,76 In the field of electronic sensors, sensor devices based on gas detection are developing rapidly and stimulating the design and innovation of sensor materials. This section mainly introduces the progress in the research and application of sensor electrode materials and composite materials.…”

“…A bio-composite film based on 0D enzyme–polymer NPs decorated on 2D nanosheets (NSs) had a high active surface area and more recognition sites, which favored the mass transfer process. 75 Taking advantage of the stability of the Ag/AgCl electrode, Pu et al integrated a glucose sensor and interstitial liquid extraction electrode pair by sharing the Ag/AgCl electrode, thus simplifying the structure of the epidermal device. A three-dimensional nanocomposite structure of graphene/platinum nanoparticles/Prussian blue was modified on the surface of the working electrode of the sensor at a fixed point and controlled, which improved the sensitivity of the sensor nearly 11-fold and realized the precision detection of low-concentration glucose.…”

EDTA derived graphene supported porous cobalt hexacyanoferrate nanospheres as a highly electroactive nanocomposite for hydrogen peroxide sensing

“…26 In graphene-nanocomposite-based electrochemical sensors, the large surface area of graphene allows the adsorption of a higher density of analyte molecules, thus facilitating achievement of higher sensitivity and device miniaturization. 27 Different graphene nanocomposites based on noble metals, 28,29 metal oxides, 30,31 polymers, [32][33][34] and hexacyanoferrates 35 have been used to develop highly sensitive H 2 O 2 non-enzymatic electrochemical sensors. 9 Among these, hexacyanoferrate-based graphene nanocomposites are recommended due to their excellent electrocatalytic activity.…”