Hierarchical mesoporous silica nanoparticles for tailorable drug release

Wu, Wei; Ye, Chenyu; Xiao, Hong; Sun, Xiaowen; Qu, Wenhao; Li, Xiuhua; Chen, Min; Li, Jianshu

doi:10.1016/j.ijpharm.2016.06.133

Cited by 30 publications

(12 citation statements)

References 56 publications

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“…Thus, MSn had the structural advantages, such as ordered pore structure, high surface area, high pore volume and high drug-loading capacity, as drug carriers such as SBA-15. 36 , 37 Nanoscale channels of MSn could restrict the drug to be present in an amorphous state rather than the crystalline state. Therefore, the dissolution rate of drugs could be significantly improved.…”

Section: Resultsmentioning

confidence: 99%

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Bai

et al. 2018

DDDT

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BackgroundBiopharmaceutics classification system class II drugs have low solubility, which limits their extent and speed of absorption after oral administration. Over the years, mesoporous materials have been widely used to increase the dissolution rate and oral relative bioavailability of poorly water-soluble drugs.ObjectivesIn order to improve the dissolution rate and increase oral relative bioavailability of the poorly water-soluble drugs, a tin oxide carrier (MSn) with a mesoporous structure was successfully synthesized.MethodsIn this study, MSn was synthesized using mesoporous silica material (SBA-15) as the template. Fenofibrate (FNB) was adsorbed into the channels of MSn by an adsorption method. Characterizations of the pure FNB, MSn, physical mixture of the drug and MSn (PM; 1:1) and FNB-loaded MSn (FNB-MSn) samples were carried out by the scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption/desorption, powder X-ray diffractometer (PXRD), differential scanning calorimetry (DSC) and Fourier transform infrared (FT-IR) spectroscopy. Cytotoxicity assay (MTT) was used to evaluate the cytotoxicity of MSn. In vitro dissolution studies were performed to investigate the dissolution rate of FNB-MSn. In vivo pharmacokinetic studies were used to investigate the changes of plasma drug concentrations of FNB-MSn tablets and commercial FNB tablets in rabbits.ResultsDetailed characterization showed that FNB in the channels of MSn was present in an amorphous state. The in vitro release tests demonstrated that MSn with a good biocompatibility could effectively enhance the dissolution rate of FNB. Pharmacokinetic results indicated that MSn significantly increased the oral relative bioavailability of FNB.ConclusionMSn can be regarded as a promising carrier for an oral drug delivery system.

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Section: Resultsmentioning

confidence: 99%

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Bai

et al. 2018

DDDT

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“…The tremendous interest in the recent years towards elaboration of mesoporous silica materials as potential carriers for drugs is based on the advantages of these materials, such as biocompatibility, high specific surface and pore volume, tunable pore size, controlled particle size and morphology and possibility for surface functionalization [1][2][3][4][5][6][7]. In the preparation of mesoporous silica nanoparticulate systems a feasible approach is to circumvent the problems associated with poor aqueous solubility, low bioavailability and chemical stability of the loaded substance.…”

Section: Introductionmentioning

confidence: 99%

Preparation of efficient quercetin delivery system on Zn-modified mesoporous SBA-15 silica carrier

Trendafilova

Szegedi

Mihály

et al. 2017

Materials Science and Engineering: C

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Mesoporous silica material type SBA-15 was modified with different amounts of Zn (2 and 4 wt. %) by incipient wetness impregnation method in ethanol. The parent, Zn-modified and quercetin loaded samples, were characterized by XRD, N2 physisorption, TEM, thermal gravimetric analysis, UV-Vis and FT-IR spectroscopies and in vitro release of quercetin at pH 5.5 which is typical of dermal formulations. By this loading method anhydrous quercetin was formed on the silica carrier. It was found that the different hydrate forms of quercetin (dihydrate, monohydrate, anhydrite) significantly influence the physico-chemical properties of the delivery system. It was found that hydrate forms of quercetin can be differentiated by XRD and by FT-IR spectroscopic methods. Thus, by evaluating the interaction of the drug with the silica carrier the changes due to its hydration state always have to be taken into account. Formation of Zn-quercetin complex was evidenced on zinc modified SBA-15 silica by FT-IR spectroscopy. High quercetin loading capacity (over 40 wt. %) could be achieved on the parent and Zn-containing SBA-15 samples. The in-vitro release process at pH=5.5 showed slower quercetin release from Zn-modified SBA-15 samples compared to the parent one.Additionally, the comparative cytotoxic experiments evidenced that quercetin encapsulated in Zn-modified silica carriers has superior antineoplastic potential against HUT-29 cells compared to free drug. Zn-modified SBA-15 silica particles could be promising carriers for dermal delivery of quercetin.

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“…[55][56][57][58] As mentioned, Dox as the model drug can be loaded in the hydrophobic region of PLGAbased nanoparticles through interactions, ie, physical encapsulation and electrostatic attraction. Dox LE/EE in PLGA and PLGA-PEG-FA were determined to be 8.2%/89.3% and 7.9%/85.8%, respectively (Table S2).…”

Section: In Vitro Drug Release and Cellular Uptakementioning

confidence: 99%

Dual tumor-targeted poly(lactic-<em>co</em>-glycolic acid)–polyethylene glycol–folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery

Chen¹,

Wu²,

Luo³

et al. 2017

IJN

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Further specific target-ability development of biodegradable nanocarriers is extremely important to promote their security and efficiency in antitumor drug-delivery applications. In this study, a facilely prepared poly(lactic- co -glycolic acid) (PLGA)–polyethylene glycol (PEG)–folic acid (FA) copolymer was able to self-assemble into nanoparticles with favorable hydrodynamic diameters of around 100 nm and negative surface charge in aqueous solution, which was expected to enhance intracellular antitumor drug delivery by advanced dual tumor-target effects, ie, enhanced permeability and retention induced the passive target, and FA mediated the positive target. Fluorescence-activated cell-sorting and confocal laser-scanning microscopy results confirmed that doxorubicin (model drug) loaded into PLGA-PEG-FA nanoparticles was able to be delivered efficiently into tumor cells and accumulated at nuclei. In addition, all hemolysis, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, and zebrafish-development experiments demonstrated that PLGA-PEG-FA nanoparticles were biocompatible and secure for biomedical applications, even at high polymer concentration (0.1 mg/mL), both in vitro and in vivo. Therefore, PLGA-PEG-FA nanoparticles provide a feasible controlled-release platform for secure and efficient antitumor drug delivery.

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Hierarchical mesoporous silica nanoparticles for tailorable drug release

Cited by 30 publications

References 56 publications

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Preparation of efficient quercetin delivery system on Zn-modified mesoporous SBA-15 silica carrier

Dual tumor-targeted poly(lactic-<em>co</em>-glycolic acid)–polyethylene glycol–folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery

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Hierarchical mesoporous silica nanoparticles for tailorable drug release

Cited by 30 publications

References 56 publications

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Development of a tin oxide carrier with mesoporous structure for improving the dissolution rate and oral relative bioavailability of fenofibrate

Preparation of efficient quercetin delivery system on Zn-modified mesoporous SBA-15 silica carrier

Dual tumor-targeted poly(lactic-<em>co</em>-glycolic acid)&ndash;polyethylene glycol&ndash;folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery

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Dual tumor-targeted poly(lactic-<em>co</em>-glycolic acid)–polyethylene glycol–folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery