Hierarchically Designed Bioactive Glassy Nanocoatings for the Growth of Faster and Uniformly Dense Apatite

Das, Indranee; Medda, Samar Kumar; De, Goutam; Fagerlund, Susanne; Hupa, Leena; Puska, Mervi; Vallittu, Pekka K.

doi:10.1111/jace.13626

Cited by 9 publications

(5 citation statements)

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“…Predominantly, the carbonate ions are present as B-type carbonates in natural bone minerals [3]. Synthetic CHAs have been widely used in a variety of biomedical applications including osteoconductive coatings [4][5][6], bone-substitute biomaterials [7], and vehicles for drug delivery [ 8]. Recently, hydoxyapatite nanorods have been prepared by an ethanol-induced method [9], liquid crystals [10], sonochemical synthesis [11], sol-gel method [12], and hydrothermal reaction [13,14].…”

mentioning

confidence: 99%

Hydrothermal Synthesis and Biocompatibility Study of Highly Crystalline Carbonated Hydroxyapatite Nanorods

Xue¹,

Chen²,

Huang³

et al. 2016

Nano Online

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(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Highly crystalline carbonated hydroxyapatite (CHA) nanorods with different carbonate contents were synthesized by a novel hydrothermal method. The crystallinity and chemical structure of synthesized nanorods were studied by Fourier transform infrared spectroscopy (FTIR), X-ray photo-electronic spectroscopy (XPS), X-ray diffraction (XRD), Raman spectroscopy, and transmission electron microscopy (TEM). The biocompatibility of synthesized CHA nanorods was evaluated by cell viability and alkaline phosphatase (ALP) activity of MG-63 cell line. The biocompatibility evaluation results show that these CHA nanorods are biologically active apatites and potentially promising bone-substitute biomaterials for orthopedic application.Keywords: Hydroxyapatite; Carbonated hydroxyapatite; Nanorods; Cell viability; Alkaline phosphatase activity; MG-63 cell BackgroundHydroxyapatite (HA) is the main inorganic component of human bone mineral, and the content of carbonate in human bone mineral is about 5-8 wt % [1, 2]. Carbonate ions in carbonated hydroxyapatites (CHA) substitute both the phosphate and hydroxyl sites of the HA structure and each is called A-type CHA and B-type CHA, respectively. Predominantly, the carbonate ions are present as B-type carbonates in natural bone minerals [3]. Synthetic CHAs have been widely used in a variety of biomedical applications including osteoconductive coatings [4][5][6], bone-substitute biomaterials [7], and vehicles for drug delivery [ 8]. Recently, hydoxyapatite nanorods have been prepared by an ethanol-induced method [9], liquid crystals [10], sonochemical synthesis [11], sol-gel method [12], and hydrothermal reaction [13,14]. However, few methods have been reported for the preparation of carbonated hydroxyapatite nanorods with different carbonate contents. Since carbonate ion substitution in the apaptite lattice plays a major role in the biochemistry and physical properties of biological apatites, it is important to develop convenient ways for the synthesis of CHA nanorods with different carbonate contents and understand how various carbonate contents affect the crystal structure and biocompatibility of CHA nanorods. Table 1 Synthesizing materials for preparing HA and CHA nanorods SamplesCaThe hydrothermal method is a typical process which has been widely used in synthesis of inorganic materials for its good repeatability and crystallinity control [15][16][17]. In this study, we developed a hydrothermal process to synthesize carbonated hydroxyapatite nanorods with different carbonate contents, using ethylene diamine tetraacetic aci...

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confidence: 99%

Hydrothermal Synthesis and Biocompatibility Study of Highly Crystalline Carbonated Hydroxyapatite Nanorods

Xue¹,

Chen²,

Huang³

et al. 2016

Nano Online

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“…Using the methods described in this chapter, bioactive glass coatings were obtained on substrates of stainless steel [130][131][132][133][134][135][136], magnesium and its alloys [137][138][139][140], PET [141], titanium [36,[142][143][144], and alloys such as Ti-6Al-4V [145,146] and NiTi [147], silica [148], etc. These alloys possess a high strength, low elastic module, and good biocompatibility In the case of electrodeposition, the substrate must conduct electricity and its shape can be complex.…”

Section: Sol-gel Deposition Techniquementioning

confidence: 99%

Bioactive Glass—An Extensive Study of the Preparation and Coating Methods

Maximov

Crăciun

et al. 2021

Coatings

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Diseases or complications that are caused by bone tissue damage affect millions of patients every year. Orthopedic and dental implants have become important treatment options for replacing and repairing missing or damaged parts of bones and teeth. In order to use a material in the manufacture of implants, the material must meet several requirements, such as mechanical stability, elasticity, biocompatibility, hydrophilicity, corrosion resistance, and non-toxicity. In the 1970s, a biocompatible glassy material called bioactive glass was discovered. At a later time, several glass materials with similar properties were developed. This material has a big potential to be used in formulating medical devices, but its fragility is an important disadvantage. The use of bioactive glasses in the form of coatings on metal substrates allows the combination of the mechanical hardness of the metal and the biocompatibility of the bioactive glass. In this review, an extensive study of the literature was conducted regarding the preparation methods of bioactive glass and the different techniques of coating on various substrates, such as stainless steel, titanium, and their alloys. Furthermore, the main doping agents that can be used to impart special properties to the bioactive glass coatings are described.

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“…3b) showed complete removal of organics. 10,11,21,40 During soaking in body uid (pH $ 7.4), initially these surface OH groups aer deprotonation absorb Ca 2+ through electrostatic force, then HPO 4 2À available in uid shis towards the surface of the coated implant to attach with Ca 2+ promoting the formation of apatite crystals. 3b) can be attributed to the vibration of Zr-OH and Zr-O-Zr linkages, respectively.…”

Section: Structural and Compositional Analysesmentioning

confidence: 99%

“…21,22 The preparation process, crystalline phase pattern and surface microstructure inuence the bioactivity of ZrO 2 . 21,22 The preparation process, crystalline phase pattern and surface microstructure inuence the bioactivity of ZrO 2 .…”

Section: In Vitro Apatite Forming Bioactivity Of Z-cptimentioning

confidence: 99%

Fabrication of a cubic zirconia nanocoating on a titanium dental implant with excellent adhesion, hardness and biocompatibility

et al. 2016

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A crystalline cubic zirconia (ZrO 2 ) nanocoating was fabricated in situ on commercially pure titanium metal (cpTi) as a superior dental implant with enhanced biocompatibility. The crystallinity of the nanocoating was achieved at a moderately lower annealing temperature (350 C) in air using a simple sol-gel method applying a successive layer-by-layer dip-coating technique. Such a procedure facilitates the growth of cubic phase zirconia without noticeable deterioration of the metallic Ti. The bioactivity and biocompatibility of this ZrO 2 coated cpTi (Z-cpTi) were assessed in terms of apatite precipitation through immersion in simulated body fluid, and cell proliferation, respectively for several periods of time. The newly designed Z-cpTi showed unique apatite forming ability, better biocompatibility and tissue attachment properties, and is expected to reduce inflammatory response compared to the bare Ti implants. Moreover, the chemical inertness, corrosion and wear resistant properties, high strength, and appearance of this ZrO 2 nanocoating suggest the probable expediency of Z-cpTi as an advanced oral implant for long-standing performance. † Electronic supplementary information (ESI) available: GIXRD patterns of dried and heat-treated 3L-ZrO 2 coating on glass (Fig. S1), TEM with SAED pattern of the dried ZrO 2 coating material (Fig. S2). See

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Hierarchically Designed Bioactive Glassy Nanocoatings for the Growth of Faster and Uniformly Dense Apatite

Cited by 9 publications

References 36 publications

Hydrothermal Synthesis and Biocompatibility Study of Highly Crystalline Carbonated Hydroxyapatite Nanorods

Hydrothermal Synthesis and Biocompatibility Study of Highly Crystalline Carbonated Hydroxyapatite Nanorods

Bioactive Glass—An Extensive Study of the Preparation and Coating Methods

Fabrication of a cubic zirconia nanocoating on a titanium dental implant with excellent adhesion, hardness and biocompatibility

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