Hierarchically micro-patterned nanofibrous scaffolds with a nanosized bio-glass surface for accelerating wound healing

He, Xu; Lv, Fang; Zhang, Yali; Yi, Zhengfang; Ke, Qinfei; Wu, Chengtie; Liu, Mingyao; Chang, Jiang

doi:10.1039/c5nr04802h

Cited by 104 publications

(75 citation statements)

References 47 publications

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“…Hierarchical surfaces, containing micro‐ and nanostructured patterns, have been shown to have the strongest influence on the cell functions . In a recent study, Xu et al reported that the hierarchical micro‐/nanostructures and nanosized bioglass in the nanofiber scaffolds have higher bioactivity and accelerate tissue regeneration . Khampieng et al selected PCL films with various surface topologies to investigate protein absorption and behavior of mouse‐calvaria‐derived pre‐osteoblastic cells.…”

Section: Effects Of Surface Properties On Cellular Behaviorsmentioning

confidence: 99%

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani

Arzaghi

Bayandori

et al. 2019

Adv Materials Inter

321

200

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Surface interaction at the biomaterial–cell interface is essential for a variety of cellular functions, such as adhesion, proliferation, and differentiation. Nevertheless, changes in the biointerface enable to trigger specific cell signaling and result in different cellular responses. In order to manufacture biomaterials with higher functionality, biomaterials containing immobilized bioactive ligands have been widely introduced and employed for tissue engineering and regenerative medicine applications. Moreover, a number of physical and chemical strategies have been used to improve the functionality of biomaterials and specifically at the material interface. Here, the interactions between materials and cells at the interface levels are described. Then, the importance of surface properties in cell function is discussed and recent methods for surface modifications are systematically highlighted. Additionally, the impact of bulk material properties on the cellular responses is briefly reviewed.

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Section: Effects Of Surface Properties On Cellular Behaviorsmentioning

confidence: 99%

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani

Arzaghi

Bayandori

et al. 2019

Adv Materials Inter

321

200

View full text Add to dashboard Cite

show abstract

“…These poly-thioketal urethane-based scaffolds were stable for 25 weeks in aqueous conditions but were degraded by tissue ROS in 7 weeks resulting in enhanced wound closure compared to polyester urethane dressings (Martin et al, 2014). Biomaterials based on bioglasses have recently also shown potential in enhancing wound healing and angiogenesis in animal model of wound healing (Mao et al, 2015; Xu et al, 2015; Zhao et al, 2015; Yu et al, 2016; Zhou et al, 2016). For instance, copper-doped borate bioactive glass microfibers were shown to increase both the rate of collagen deposition and angiogenesis in full-thickness wounds in rats (Zhao et al, 2015).…”

Section: Biomaterial-based Wound Therapiesmentioning

confidence: 99%

Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing

Baker

2016

Front. Bioeng. Biotechnol.

254

196

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Wound healing is an intricate process that requires complex coordination between many cell types and an appropriate extracellular microenvironment. Chronic wounds often suffer from high protease activity, persistent infection, excess inflammation, and hypoxia. While there has been intense investigation to find new methods to improve cutaneous wound care, the management of chronic wounds, burns, and skin wound infection remain challenging clinical problems. Ideally, advanced wound dressings can provide enhanced healing and bridge the gaps in the healing processes that prevent chronic wounds from healing. These technologies have great potential for improving outcomes in patients with poorly healing wounds but face significant barriers in addressing the heterogeneity and clinical complexity of chronic or severe wounds. Active wound dressings aim to enhance the natural healing process and work to counter many aspects that plague poorly healing wounds, including excessive inflammation, ischemia, scarring, and wound infection. This review paper discusses recent advances in the development of biomaterials and nanoparticle therapeutics to enhance wound healing. In particular, this review focuses on the novel cutaneous wound treatments that have undergone significant preclinical development or are currently used in clinical practice.

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“…[12] Indeed, recent studies have claimed accelerated wound healing when applying composite materials containing bioactive glasses on skin injuries. [13,14,15] The release of ions while bioceramics degrade seem to be behind their stimulatory effects, as observed in in vitro studies in which cells are stimulated by media previously incubated with bioceramics. [16,17,18] However, little attention has been paid to unveiling the individual biological contribution of each of the ionic species.…”

Section: Introductionmentioning

confidence: 99%

“…For wound healing purposes, most of the studies have used silica-based bioglasses with a relatively low calcium content and release. [13,14,15] One of the most important objectives in tissue engineering is to direct cell behavior by achieving full control of their surrounding microenvironment. [26] Nanotechnology provides efficient tools to introduce suitable signals in biomaterials, allowing us to turn these microenvironments into regenerative milieus.…”

Section: Introductionmentioning

confidence: 99%

Wound healing-promoting effects stimulated by extracellular calcium and calcium-releasing nanoparticles on dermal fibroblasts

et al. 2018

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Extracellular calcium has been proved to influence the healing process of injuries and could be used as a novel therapy for skin wound healing. However, a better understanding of its effect, together with a system to obtain a controlled release is needed. In this study, we examined whether the ionic dissolution of the calcium-phosphate-based ormoglass nanoparticles coded SG5 may produce a similar stimulating effect as extracellular calcium (from CaCl) on rat dermal fibroblast in vitro. Cells were cultured in the presence of medium containing different calcium concentrations, normally ranging from 0.1 to 3.5 mM Ca. A concentration of 3.5 mM of CaCl increased metabolic activity, in vitro wound closure, matrix metalloproteinases (MMP) activity, collagen synthesis and cytokine expression, and reduced cell contraction capacity. Interestingly, the levels of migration and contraction capacity measured followed a dose-dependent behavior. In addition, media conditioned with SG5 stimulated the same activities as media conditioned with CaCl, but undesired effects in chronic wound healing such as inflammatory factor expression and MMP activity were reduced compared to the equivalent CaCl concentration. In summary, calcium-releasing particles such as SG5 are potential biological-free biostimulators to be applied in dressings for chronic wound healing.

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Hierarchically micro-patterned nanofibrous scaffolds with a nanosized bio-glass surface for accelerating wound healing

Cited by 104 publications

References 47 publications

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing

Wound healing-promoting effects stimulated by extracellular calcium and calcium-releasing nanoparticles on dermal fibroblasts

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