High Accumulation of Endothelial Nitric Oxide Synthase (ecNOS):A Gene Polymorphism in Patients with End-Stage Renal Disease

Yokoyama, Keitaro; Tsukada, Toshihiko; Matsuoka, Hiroaki; Hara, Sigeko; Yamada, Akira; Kawaguchi, Yoshindo

doi:10.1159/000045069

Cited by 31 publications

(21 citation statements)

References 3 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wanget al reported an excess coronary risk in patients with ecNOS4a/a, which is smoking dependent (7). Renal failure and essential hypertension in Japanese might be associated with the a-allele of the ecNOS4 gene (8,9). While there is a discrepancy in the data on NOmetabolites, the a-allele of the ecNOS4gene is likely a risk for vascular disorder.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Wang et al reported an association between the higher susceptibility to coronary lesions and a particular genotype of the ecNOS4gene in smokers (7). Yokoyamaet al suggested that the ecNOS4gene polymorphism is involved in the pathophysiology of chronic renal diseases (8). Uwaboet al have shown that this polymorphism is a genetic marker for essential hypertension in Japanese (9).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Allele Frequency of Human Endothelial Nitric Oxide Synthase Gene Polymorphism in Abdominal Aortic Aneurysm.

et al. 2000

View full text Add to dashboard Cite

Objective This study was performed to examine the role of the endothelial constitutive NOsynthase (ecNOS) gene in patients with abdominal aortic aneurysm (AAA). Methods We determined the distributions of polymorphism in intron 4 of the ecNOS (ecNOS4) gene, amplified by polymerase chain reaction, and comparedthe allele frequencies between subjects with abdominalaortic aneurysms (AAAs) and healthy individuals.Patients Fifty-eight patients with AAAsand 410 racematched healthy controls were studied. Results Two alleles of the ecNOS4gene, containing 4 (a-allele) and 5 (b-allele) repeats, were identified. We found that the a-allele frequency of this gene was significantly higher in the surgical than in the non-surgical group. Conclusion The results of this study suggest that the aallele of the ecNOS4gene is indicative of the need for surgery for AAA.Analysis of the alleles of the ecNOS4 gene polymorphism could provide useful information concerning the clinical course of AAAprogression.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Allele Frequency of Human Endothelial Nitric Oxide Synthase Gene Polymorphism in Abdominal Aortic Aneurysm.

et al. 2000

View full text Add to dashboard Cite

show abstract

“…These findings suggest that abnormal activity or expression of ecNOS could have pathological vascular effects. Recently, Yokoyama et al [10]and Wang et al [11]reported that polymorphism of intron 4 of the ecNOS gene might be associated with the progression of renal failure in nondiabetic renal disease. The present study attempted to verify the hypothesis that ecNOS intron 4 polymorphism is of relevance to the progression of chronic renal failure.…”

Section: Introductionmentioning

confidence: 99%

Endothelial Nitric Oxide Synthase Intron 4 Polymorphism Influences the Progression of Renal Disease

Asakimori

Yorioka

Yamamoto

et al. 2001

Nephron

View full text Add to dashboard Cite

Background/Aim: Nitric oxide is a potent regulator of intrarenal hemodynamics and may influence the renal function. We investigated whether polymorphism of intron 4 of the endothelial constitutive nitric oxide synthase (ecNOS) gene is related to the progression of chronic renal failure. Methods: Polymorphism of ecNOS intron 4 was studied in 1,005 hemodialysis patients (710 with nondiabetic nephropathy and 295 with diabetic nephropathy) and was compared with the findings in 189 healthy subjects. ecNOS genotypes were determined by the polymerase chain reaction, followed by agarose gel electrophoresis. Results: The frequencies of ecNOS4a/a, ecNOS4a/b, and ecNOS4b/b genotypes were, respectively, 0% (0/189), 13.8% (26/189), and 86.2% (163/189) in the control group; 1.7% (12/710), 22.1% (157/710), and 76.2% (541/710) in the nondiabetic nephropathy group, and 1.0% (3/295), 22.7% (67/295), and 76.3% (225/295) in the diabetic nephropathy group. The frequency of ecNOS4a (ecNOSa/a and ecNOSa/b) was significantly higher in both the nondiabetic group and in the diabetic group than in the controls (p = 0.0025 and p = 0.0438, respectively). Conclusion: There was a significantly higher frequency of the a allele of intron 4 in both nondiabetic and diabetic hemodialysis patients, so the polymorphism of intron 4 of the ecNOS gene may have a wide influence on the progression of renal disease.

show abstract

“…35 However, eNOS haplotype association was observed in patients with biopsy-proven giant cell vasculitis, a large blood vessel vasculitis involving mainly elderly people, when compared with matched controls. 36 Association between Glu298Asp gene polymorphism and many renal sequales including end-stage renal disease, [37][38] glomerulonephritis, 39 diabetic nephropaty, 40 and immunoglobulin A nephropaty 41 have been reported. Serrano et al 42 suggested that eNOS deficiency may affect the severity of gastrointestinal complications.…”

Section: Discussionmentioning

confidence: 99%

Inspection of Endothelial Nitric Oxide Synthase Gene Polymorphism in Patients With Henoch Schönlein Purpura

et al. 2014

View full text Add to dashboard Cite

High Accumulation of Endothelial Nitric Oxide Synthase (ecNOS):A Gene Polymorphism in Patients with End-Stage Renal Disease

Cited by 31 publications

References 3 publications

Allele Frequency of Human Endothelial Nitric Oxide Synthase Gene Polymorphism in Abdominal Aortic Aneurysm.

Allele Frequency of Human Endothelial Nitric Oxide Synthase Gene Polymorphism in Abdominal Aortic Aneurysm.

Endothelial Nitric Oxide Synthase Intron 4 Polymorphism Influences the Progression of Renal Disease

Inspection of Endothelial Nitric Oxide Synthase Gene Polymorphism in Patients With Henoch Schönlein Purpura

Contact Info

Product

Resources

About