This paper describes the experimental and analytical performance of robot drilling on alloy materials. In heavy structures manual drilling consumes time and quality of holes drilled is unstable. The industrial robot with agile motion is possible to machine a component. Industrial robots with high precision and six axis Degree of freedom are considered for better robot manufacturing processes. This work is to significantly improve performance of robot drilling over conventional drilling. The industrial manipulator used is ABB - IRB1410 with work volume of 2.6 meters and controlled by IRC5 Controller. Drilling machine utilized is specified with maximum speed of 3000 RPM. The speed of the drilling machine can be varied by voltage regulator and maintain different speeds at a difference of 100 RPM. The parameters like surface roughness, time consumed, circular entry and exit, roundness is considered. Relay is utilized to turn on/off the drill at the required places. The industrial manipulator robot and vertical CNC machine drillings are compared by random values of Design of Experiments. The process parameters like drill bit size, speed of drill and feed rate are considered. Conventional material removal techniques like CNC have been proven to be able to tackle nearly any machining challenge but major drawback of using conventional CNC machine is restricted work volume