High altitude and spontaneous preterm birth

Ali, K.Z.M.; Ali, M.E.; Khalid, M.E.M.

doi:10.1016/0020-7292(96)02673-2

Cited by 19 publications

(6 citation statements)

References 6 publications

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“…The prevalence of total preterm birth in our study found to be (8%). Compared to other cities of Kingdom of Saudi Arabia, Similar findings were reported in Jazan (8.24%) [ 16 ], while others in Riyadh and Abha cities reported lower rates (5%) [ 17 , 18 ]. Compared to another part of the world, it is found to be more or less equal to that in Asian (9.8%) and European countries (6.7%), but less than in African (12.6%) and Vietnam (11.8%) [ 19 ].…”

Section: Discussionsupporting

confidence: 75%

Risk Factors for Early Preterm Birth at King Salman Armed Force Hospital in 2010

Alansi¹,

Mukhtar²,

Alazizi³

et al. 2017

Open Access Maced J Med Sci

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AIM:To investigate risk factors for early preterm birth.METHODS AND MATERIAL:A retrospective comparative study was conducted at Tabuk, Kingdom of Saudi Arabia during the period from January to December 2010. Five hundred and ninety-five patient’s files and delivery registry logbooks were reviewed, the following information was collected; demographic data, current and past obstetric histories. Then the early and late preterm births were compared for various risk factors. The Statistical Package for Social Sciences (SPSS version 22) was used. The Chi-square and t-test were used to test the statistical significance and a P-value<0.05 considered significant.RESULTS:Prevalence of early preterm birth was found to be 2.5% in our study group. Women at risk for early preterm birth were: primigravidas (33.7% vs. 26.2% for control), P-value 0.039, OR 1.429 and 95% CI 0.982 - 2.079); multiple gestations (87.7% vs. 95.1% for control, P-value 0.002, OR 0.368 and 95% CI 0.196 - 0.688); and patients with a prior history of placental abruption (3.7% vs. 1.0% for control, P-value 0.027, OR3.928 and 95% CI 1.1360 - 13.586).CONCLUSIONS:Current study indicated that early preterm births differed from preterm as a whole; primigravida, multiple gestations and a history of placental abruption are independent risk factors for them.

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Section: Discussionsupporting

confidence: 75%

Risk Factors for Early Preterm Birth at King Salman Armed Force Hospital in 2010

Alansi¹,

Mukhtar²,

Alazizi³

et al. 2017

Open Access Maced J Med Sci

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“…Birth weight is reduced in high‐altitude infants, the rate of low birth weight is increased three‐ to fivefold, and maternal and neonatal mortality are markedly increased in the absence of optimal medical care 1 , 10 . Contributing to mortality are pre‐term labor and delivery, and an increase in hypertensive complications of pregnancy, especially preeclampsia, a serious and potentially fatal pregnancy‐related vascular disease 1 , 11 –17 . The underlying cause(s) of these suboptimal pregnancy outcomes at high altitude is still under investigation, but it is clear that altered vascular function during pregnancy resulting from the chronic stress of maternal hypoxia plays an important role in the reduced birth weights and increased complications observed 11 , 18 –20 …”

Section: Introductionmentioning

confidence: 99%

High Altitude Residence During Pregnancy Alters Cytokine and Catecholamine Levels

Coussons-Read¹,

Mazzeo

Whitford

et al. 2002

American J Rep Immunol

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This study assessed the impact of high altitude residence during pregnancy on parameters of maternal immune and endocrine system function. Urinary catecholamines, and serum cytokines, estriol, and cortisol were assessed during pregnancy in women living at moderate or high altitude. Women residing at high altitude exhibited elevated levels of proinflammatory cytokines only during pregnancy, and tended to have higher levels of catecholamines during pregnancy than women living at lower altitude. These data suggest that the combination of high altitude and pregnancy alters the maternal neural-immune axis in a manner that may predispose women to suboptimal birth outcomes.

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“…This hypothesis is supported by clinical and experimental evidence; for example, pregnant women at high altitude (>4,000 meters above sea level) have triple chance of premature delivery than women living at sea level (12 versus 4%) [14]. Clinical conditions that are a reflection of placental ischemia, such as preeclampsia and fetal growth restriction, are frequently associated with premature onset of labor [5, 15].…”

Section: Uteroplacental Ischemia and Preterm Birthmentioning

confidence: 99%

Docosahexaenoic Acid Supplementation Early in Pregnancy May Prevent Deep Placentation Disorders

Carvajal

2014

BioMed Research International

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Uteroplacental ischemia may cause preterm birth, either due to preterm labor, preterm premature rupture of membranes, or medical indication (in the presence of preeclampsia or fetal growth restriction). Uteroplacental ischemia is the product of defective deep placentation, a failure of invasion, and transformation of the spiral arteries by the trophoblast. The failure of normal placentation generates a series of clinical abnormalities nowadays called “deep placentation disorders”; they include preeclampsia, fetal growth restriction, preterm labor, preterm premature rupture of membranes, in utero fetal death, and placental abruption. Early reports suggested that a LC-PUFAs (long chain polyunsaturated fatty acids) rich diet reduces the incidence of deep placentation disorders. Recent randomized controlled trials are inconsistent to show the benefit of docosahexaenoic acid (DHA) supplementation during pregnancy to prevent deep placentation disorders, but most of them showed that DHA supplementation was associated with lower risk of early preterm birth. We postulate that DHA supplementation, early in pregnancy, may reduce the incidence of deep placentation disorders. If our hypothesis is correct, DHA supplementation, early in pregnancy, will become a safe and effective strategy for primary prevention of highly relevant pregnancy diseases, such as preterm birth, preeclampsia, and fetal growth restriction.

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High altitude and spontaneous preterm birth

Cited by 19 publications

References 6 publications

Risk Factors for Early Preterm Birth at King Salman Armed Force Hospital in 2010

Risk Factors for Early Preterm Birth at King Salman Armed Force Hospital in 2010

High Altitude Residence During Pregnancy Alters Cytokine and Catecholamine Levels

Docosahexaenoic Acid Supplementation Early in Pregnancy May Prevent Deep Placentation Disorders

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