High Amount of Dietary Fiber Not Harmful But Favorable for Crohn Disease

Chiba, Mitsuro; Tsuji, Takeshi; Nakane, Kunio; Komatsu, Masafumi

doi:10.7812/tpp/14-124

Cited by 44 publications

(31 citation statements)

References 23 publications

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“…There is also emerging evidence that SVDs could be an option for patients with IBD, such as Crohn’s disease (30). While the mechanisms behind this are yet to be confirmed, it has been speculated that a plant-based diet may be effective for gut inflammation, namely, through the actions of dietary fiber (31).…”

Section: Discussionmentioning

confidence: 99%

“…One study observed that SVDs helped to prevent relapse of symptoms in patients with inflammatory bowel disease (IBD) (29). Additional research by the same team concluded that up to 32.4 g dietary fiber, delivered via an SVD could be given to patients with IBD, indicating that these could be used as a supportive treatment for Crohn’s disease patients (30). …”

Section: Healthmentioning

confidence: 99%

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Flexitarian Diets and Health: A Review of the Evidence-Based Literature

2017

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A flexitarian or semi-vegetarian diet (SVD) is one that is primarily vegetarian with the occasional inclusion of meat or fish. Of late, there appears to be an increasing movement toward this practice. There has not been a recent update on these diets from a health perspective. Using the National Centre for Biotechnology Information PubMed database, a search was made for all studies published between 2000 and 2016 that met defined inclusion criteria. A total of 25 studies were located with 12 focusing on body weight and diet quality. There was emerging evidence suggestive of benefits for body weight, improved markers of metabolic health, blood pressure, and reduced risk of type 2 diabetes. SVD may also have a role to play in the treatment of inflammatory bowel diseases, such as Crohn’s disease. Given that there is a higher tendency for females to be flexitarian yet males are more likely to overconsume meat, there is a clear need to communicate the potential health benefits of these diets to males.

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Section: Discussionmentioning

confidence: 99%

Section: Healthmentioning

confidence: 99%

Flexitarian Diets and Health: A Review of the Evidence-Based Literature

2017

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“…There is another recent study of fiber supplementation that also claims benefit, and this was through the uncontrolled use of an ovovegetarian diet with over 30 g of fiber for every 2000 kcal. Maintenance of remission to one year was a remarkable 92% [154]. See also recommendation 8.…”

Section: Grade Of Recommendation 0 E Strong Consensus (96% Agreement)mentioning

confidence: 94%

ESPEN practical guideline: Clinical Nutrition in inflammatory bowel disease

et al. 2020

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“…The butyrate-producing microbiota has been implicated in host health in many different disease models (35,(38)(39)(40)(41)(42)(43)(44)(45)(46)(47), resulting in increased interest in studying this community. It is therefore important to have a reliable tool to identify butyrate-producing microbes and to detect their activity.…”

Section: Discussionmentioning

confidence: 99%

Function and Phylogeny of Bacterial Butyryl Coenzyme A:Acetate Transferases and Their Diversity in the Proximal Colon of Swine

Trachsel

Bayles

Looft

et al. 2016

Appl Environ Microbiol

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Studying the host-associated butyrate-producing bacterial community is important, because butyrate is essential for colonic homeostasis and gut health. Previous research has identified the butyryl coenzyme A (CoA):acetate-CoA transferase (EC 2.3.8.3) as a gene of primary importance for butyrate production in intestinal ecosystems; however, this gene family (but) remains poorly defined. We developed tools for the analysis of butyrate-producing bacteria based on 12 putative but genes identified in the genomes of nine butyrate-producing bacteria obtained from the swine intestinal tract. Functional analyses revealed that eight of these genes had strong But enzyme activity. When but paralogues were found within a genome, only one gene per genome encoded strong activity, with the exception of one strain in which no gene encoded strong But activity. Degenerate primers were designed to amplify the functional but genes and were tested by amplifying environmental but sequences from DNA and RNA extracted from swine colonic contents. The results show diverse but sequences from swine-associated butyrate-producing bacteria, most of which clustered near functionally confirmed sequences. Here, we describe tools and a framework that allow the bacterial butyrate-producing community to be profiled in the context of animal health and disease. IMPORTANCEButyrate is a compound produced by the microbiota in the intestinal tracts of animals. This compound is of critical importance for intestinal health, and yet studying its production by diverse intestinal bacteria is technically challenging. Here, we present an additional way to study the butyrate-producing community of bacteria using one degenerate primer set that selectively targets genes experimentally demonstrated to encode butyrate production. This work will enable researchers to more easily study this very important bacterial function that has implications for host health and resistance to disease. S hort-chain fatty acids (SCFAs) play a central role in the maintenance of colonic homeostasis, which is the delicate balance between the host, its immune system, and the gastrointestinal microbial partners (1). Butyrate in particular has potent effects on host tissues. As with other SCFAs, butyrate is consumed by the host as an energy source; however, unlike the other common SCFAs, such as propionate and acetate, butyrate is the preferred energy source for colonocytes (2) and is rapidly absorbed and used by the colonic epithelium. This rapid oxidation of butyrate reduces local oxygen concentrations, causing the epithelia to become hypoxic and thus limiting the growth of facultative aerobic pathogens, such as Salmonella species (3, 4). In addition, butyrate alters host gene expression to promote immune tolerance to the colonic microbiota and to improve the barrier function of the colonic epithelium. For example, butyrate has been shown to increase the secretion of antimicrobial peptides and mucus as well as the expression of tight junction proteins, thickening and strengthenin...

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High Amount of Dietary Fiber Not Harmful But Favorable for Crohn Disease

Cited by 44 publications

References 23 publications

Flexitarian Diets and Health: A Review of the Evidence-Based Literature

Flexitarian Diets and Health: A Review of the Evidence-Based Literature

ESPEN practical guideline: Clinical Nutrition in inflammatory bowel disease

Function and Phylogeny of Bacterial Butyryl Coenzyme A:Acetate Transferases and Their Diversity in the Proximal Colon of Swine

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