High‐ and low‐protein gestation diets do not provoke common transcriptional responses representing universal target‐pathways in muscle and liver of porcine progeny

Oster, Michael; Muráni, Eduard; Metges, C. C.; Ponsuksili, Siriluck; Wimmers, Klaus

doi:10.1111/apha.12192

Cited by 7 publications

(3 citation statements)

References 44 publications

(102 reference statements)

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“…In particular, researchers found that expression of genes related to oxidative phosphorylation and fatty acid metabolism were increased in LP compared with HP skeletal muscle. Based upon these transcriptional comparisons between differing tissue and dietary insults, researchers within this study concluded that liver tissue may be highly resilient to nutritional alternations whereas, skeletal muscle tissue may be less resilient to nutritional insults and is more likely to show more transcriptional differences than the liver when the gestational diet has been altered [ 91 ]. Perhaps in the event of nutritional inadequacy during fetal development, differing tissues do not experience a common transcriptional response or follow a universal target pathway in epigenetic variations.…”

Section: Maternal Protein Intake and Fetal Programmingmentioning

confidence: 99%

The Role of Maternal Dietary Proteins in Development of Metabolic Syndrome in Offspring

et al. 2015

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The prevalence of metabolic syndrome and obesity has been increasing. Pre-natal environment has been suggested as a factor influencing the risk of metabolic syndrome in adulthood. Both observational and experimental studies showed that maternal diet is a major modifier of the development of regulatory systems in the offspring in utero and post-natally. Both protein content and source in maternal diet influence pre- and early post-natal development. High and low protein dams’ diets have detrimental effect on body weight, blood pressure191 and metabolic and intake regulatory systems in the offspring. Moreover, the role of the source of protein in a nutritionally adequate maternal diet in programming of food intake regulatory system, body weight, glucose metabolism and blood pressure in offspring is studied. However, underlying mechanisms are still elusive. The purpose of this review is to examine the current literature related to the role of proteins in maternal diets in development of characteristics of the metabolic syndrome in offspring.

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Section: Maternal Protein Intake and Fetal Programmingmentioning

confidence: 99%

The Role of Maternal Dietary Proteins in Development of Metabolic Syndrome in Offspring

et al. 2015

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“…High intake of animal proteins could increase the acid load in the circulation [18], thereby promoting the formation of stress fiber mediated by RhoA in enhancing focal adhesion mechanism [18]. Oster and co-workers [41] undertook microarray analyses on skeletal muscle tissue of 253 offspring of German gilts fed with iso-caloric diets showed that the transcriptional pathway of Rho GTPase decreased in “low-protein/high-carbohydrate” diet after 188 days follow-up at postnatal subjects. Garcia et al [42] indicated that treatment with arachidonic acid in MDA-MB-435 human melanoma cells can activate RhoA promoting cell adhesion via p38 MAPK- RhoA signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Dietary protein sources and tumoral overexpression of RhoA, VEGF-A and VEGFR2 genes among breast cancer patients

et al. 2019

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Background High protein intake may promote angiogenesis giving support to the development of metastasis according to the experimental data. However, nutritional epidemiologic evidence is inconsistent with metastasis. Therefore, we aimed to study the association between dietary intake of protein and tumoral expression levels of Ras homologous gene family member A ( RhoA ), vascular endothelial growth factor-A ( VEGF-A ), and VEGF receptor-2 ( VEGFR2 ) in primary breast cancer (BC) patients. Methods Over this consecutive case series, 177 women primary diagnosed with histopathologically confirmed BC in Tabriz (Iran) were enrolled between May 2011 and November 2016. A validated food frequency questionnaire was completed for eligible participants. Fold change in gene expression was measured using quantitative real-time PCR. Principal component factor analysis (PCA) was used to express dietary groups of proteins. Results Total protein intake was associated with the expression level of VEGF-A in progesterone receptor-positive (PR+: β = 0.296, p < 0.01) and VEGFR2 in patients with involvement of axillary lymph node metastasis (ALNM+: β = 0.295, p < 0.01) when covariates were adjusted. High animal protein intake was correlated with overexpression of RhoA in tumors with estrogen receptor-positive (ER+: β = 0.230, p < 0.05), ALNM+ ( β = 0.238, p < 0.05), and vascular invasion (VI+: β = 0.313, p < 0.01). Animal protein intake was correlated with the overexpression of VEGFR2 when tumors were positive for hormonal receptors (ER+: β = 0.299, p < 0.01; PR+: β = 0.296, p < 0.01). Based on the PCA outputs, protein provided by whole meat (white and red meat) was associated inversely with RhoA expression in ALNM+ ( β = − 0.253, p < 0.05) and premenopausal women ( β = − 0.285, p < 0.01) in adjusted models. Whole meat was correlated with VEGFR2 overexpression in VI+ ( β = 0.288, p < 0.05) and premenopausal status ( β = 0.300, p < 0.05) in adjusted models. A group composed of dairy products and legumes was correlated with the overexpression of Rh...

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“…In fact, embryonic and fetal development are periods of rapid growth and cell differentiation and predetermination of later life. Adverse environmental conditions during embryonic and fetal development provoke an adaptive response, which may lead to both persistently biased responsiveness to extrinsic factors and permanent consequences for the organismal phenotype [ 10 , 11 ]. The in-ovo development of the poultry is an ideal model for studying the impact of exogenous (physical) effects and analysing mechanisms of gene-environment interactions taking place during embryonic development and potentially affecting later life time development.…”

Section: Introductionmentioning

confidence: 99%

Transient Shifts of Incubation Temperature Reveal Immediate and Long-Term Transcriptional Response in Chicken Breast Muscle Underpinning Resilience and Phenotypic Plasticity

et al. 2016

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Variations in egg incubation temperatures can have acute or long-term effects on gene transcription in avian species. Altered gene expression may, in turn, affect muscle traits in poultry and indirectly influence commercial production. To determine how changes in eggshell temperature affect gene expression, incubation temperatures were varied [36.8°C (low), 37.8°C (control), 38.8°C (high)] at specific time periods reflecting two stages of myogenesis [embryonic days (ED) 7–10 and 10–13]. Gene expression was compared between interventions and matching controls by microarrays in broiler breast muscle at ED10 or ED13 and post-hatch at day 35. Early (ED7-10) high incubation temperature (H10ΔC) resulted in 1370 differentially expressed genes (DEGs) in embryos. Ingenuity pathway analysis revealed temporary activation of cell maintenance, organismal development, and survival ability genes, but these effects were not maintained in adults. Late high incubation temperature (ED10-13) (H13ΔC) had slightly negative impacts on development of cellular components in embryos, but a cumulative effect was observed in adults, in which tissue development and nutrition metabolism were affected. Early low incubation temperature (L10ΔC) produced 368 DEGs, most of which were down-regulated and involved in differentiation and formation of muscle cells. In adults, this treatment down-regulated pathways of transcriptional processes, but up-regulated cell proliferation. Late low temperature incubation (L13ΔC) produced 795 DEGs in embryos, and activated organismal survival and post-transcriptional regulation pathways. In adults this treatment activated cellular and organ development, nutrition and small molecule activity, and survival rate, but deactivated size of body and muscle cells. Thermal interventions during incubation initiate immediate and delayed transcriptional responses that are specific for timing and direction of treatment. Interestingly, the transcriptional response to transiently decreased incubation temperature, which did not affect the phenotypes, prompts compensatory effects reflecting resilience. In contrast, higher incubation temperature triggers gene expression and has long-term effects on the phenotype. These mechanisms of considerable phenotypic plasticity contribute to the biodiversity and broaden the basis for managing poultry populations.

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High‐ and low‐protein gestation diets do not provoke common transcriptional responses representing universal target‐pathways in muscle and liver of porcine progeny

Cited by 7 publications

References 44 publications

The Role of Maternal Dietary Proteins in Development of Metabolic Syndrome in Offspring

The Role of Maternal Dietary Proteins in Development of Metabolic Syndrome in Offspring

Dietary protein sources and tumoral overexpression of RhoA, VEGF-A and VEGFR2 genes among breast cancer patients

Transient Shifts of Incubation Temperature Reveal Immediate and Long-Term Transcriptional Response in Chicken Breast Muscle Underpinning Resilience and Phenotypic Plasticity

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