High apolipoprotein E ε4 allele frequency in Age‐related memory decline

Blesa, Rafael; Adroer, Rosa; Santacruz, Pilar; Ascaso, Carlos; Tolosa, Eduardo; Oliva, Rafael

doi:10.1002/ana.410390419

Cited by 53 publications

(24 citation statements)

References 24 publications

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“…In addition, we collect 45 to 50 ml of blood from VETSA subjects for the purpose of genotyping and clinical chemistries. In the primary VETSA project, we are examining the apolipoprotein E (APOE) genotype because of the association that has been observed between the APOE-ε4 allele and cognitive deficits associated with dementia (Blesa et al, 1996;Bondi et al, 1999;Henderson et al, 1995). In the VETSA Cortisol study, we are examining the G protein-coupled receptor kinase 3 (GRK3) genotype because GRK3 plays a role in regulating corticotropin-releasing-factor (CRF 1 ) receptors (Dautzenberg et al, 2001;Dautzenberg et al, 2002), which is important in cortisol and hypothalamic-pituitary-adrenal axis function.…”

Section: Neuropsychological Measuresmentioning

confidence: 99%

Genes, Environment, and Time: The Vietnam Era Twin Study of Aging (VETSA)

et al. 2006

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Section: Neuropsychological Measuresmentioning

confidence: 99%

Genes, Environment, and Time: The Vietnam Era Twin Study of Aging (VETSA)

et al. 2006

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“…Apolipoprotein (apoE) genotyping was performed through polymerase chain reaction amplification and Hha 1 restriction enzyme digestion as previously described [27] . The presence of at least 1 4 allele made the subject to be considered as an apoE 4 carrier.…”

Section: Neurobiologymentioning

confidence: 99%

Longitudinal Study of Amnesic Patients at High Risk for Alzheimer’s Disease: Clinical, Neuropsychological and Magnetic Resonance Spectroscopy Features

Rami¹,

Gómez‐Anson

Sánchez‐Valle³

et al. 2007

Dement Geriatr Cogn Disord

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Background/Aims: To prospectively follow up a group of amnesic patients at risk for Alzheimer’s disease (AD), to characterize a group of patients whose features were intermediate between amnesic mild cognitive impairment (aMCI) and probable AD, prodromal AD (Prd-AD), and to investigate if these patients were at higher risk for AD conversion. Methods: A total of 109 subjects were assessed by neuropsychological evaluation and by ¹H magnetic resonance spectroscopy (¹H-MRS): 27 controls, and 16 aMCI, 34 probable AD and 32 Prd-AD patients. Results: Episodic memory and frontal test scores resulted lower in Prd-AD compared to aMCI patients. Prd-AD patients obtained significantly higher scores than AD ones in language, perception, praxis and frontal functions. Although Prd-AD and AD patients had distinct ¹H-MRS features from aMCI ones, there were no ¹H-MRS differences between Prd-AD and AD patients. The AD annual conversion rate after 1 year of follow-up for Prd-AD (57.1%) was higher than in aMCI patients (20%; p < 0.01). A logistic regression, in which all amnesic patients were treated as a single group, showed that the Visual Memory Test was a significant neuropsychological predictor for AD conversion. Conclusions: Prd-AD patients are a clinically distinguishable group, with distinct neuropsychological and ¹H-MRS features and a higher conversion rate to probable AD than aMCI patients.

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“…The e4 allele is described as a risk factor for Alzheimer's disease [5,6], but also for another neurodegenerative disorder, Creutzfeldt-Jakob disease [7]. The e4 allele has also been mentioned in connection with memory complaints without dementia [8] and with memory function [9].…”

Section: Introductionmentioning

confidence: 99%

A Possible Role of Apolipoprotein E Polymorphism in Predisposition to Higher Education

et al. 2001

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A potential candidate gene that could contribute to the education process is the apolipoprotein E (apo E) gene that has been shown to correlate with memory function and memory decline. We measured apo E polymorphism in groups of probands with different levels of education selected from a population sample. In the group of probands with higher education (n = 82), 24.4% had the e4 allele, compared with 7.3% who had the e2 allele. A reverse association was found in the group that left school aged 15 (n = 36) – 8.3% had the e4 allele and 13.9% had the e2 allele. Eighty-seven percent of the probands with the allele e4 reached higher education, compared to only 54.5% with the allele e2. The difference between the groups is statistically significant (p = 0.039), and this may indicate some role for the apo E polymorphism in subjects` intelligence or ability to learn.

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High apolipoprotein E ε4 allele frequency in Age‐related memory decline

Cited by 53 publications

References 24 publications

Genes, Environment, and Time: The Vietnam Era Twin Study of Aging (VETSA)

Genes, Environment, and Time: The Vietnam Era Twin Study of Aging (VETSA)

Longitudinal Study of Amnesic Patients at High Risk for Alzheimer’s Disease: Clinical, Neuropsychological and Magnetic Resonance Spectroscopy Features

A Possible Role of Apolipoprotein E Polymorphism in Predisposition to Higher Education

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