High aspect ratio diamond microelectrode array for neuronal activity measurements

Single-crystal diamond microneedles shaped at growth stage

“…2, curve 1) shows presence of a "diamond" line at 1332 cm -1 , crystalline graphite at 1580 cm -1 (well ordered) and 1350 cm -1 (disordered) and a weak "nanodiamond" lines at 1140 cm -1 and 1470 cm -1 . [13], optoelectronics [14,15], cutting micro-tools [16], and other micromechanical devices [17]. Depending on demands related to certain applications, the shape, size and structural features of the diamond crystallites could be optimized by varying the CVD and oxidation process parameters.…”

Diamond Ultramicro- and Nano-electrode Arrays

“…The diameters of electrodes are between 10 and 25 µm with a separation of 100-250 µm. Bergonzo et al [52] and Carabelli et al [53] utilized nano-crystalline diamond films to generate electrode arrays.…”

“…nitrate, 4-nitrophenol [49][50][51], Cr(VI) ions, Ag(I) ions, sulphate, peroxodisulfate [43], hydrogen peroxide [55]), for bio-detections (e.g. detection of dopamine [44][45][46][47][48], neuronal activity measurements [52,53], quantal catecholamine secretion from chromaffine cells [54]), and for the generation and detection of peroxidisulfate with the aid of scanning electrochemical microscope (SECM) [59]. We have shown that dopamine can be sensitively and selectively detected on diamond ultramicroelectrode arrays in the presence of ascorbic acid [55].…”

New perspectives for the Silicon-On-Diamond material

“…However, diamond is intensely investigated also for its radiation hardness, its solar blindness and its nearly tissue equivalence, for applications in high energy physics [8], space experiments [9] and clinical dosimetry [10]. Furthermore, its very favorable biocompatibility and electrochemical properties [11,12] make it a unique material for interfacing living cells. We envisage SOD applications, both in radiation detection and in biophysics, through the implementation of monolithic, rugged, low-noise systems where diamond is either the active sensing material or the biological interface and silicon is the carrier of the integrated electronics.…”