High blood pressure six weeks postpartum after hypertensive pregnancy disorders at term is associated with chronic hypertension

Visser, V.S.; Hermes, Wietske; Franx, Arie; Koopmans, Corine M.; Pampus, Maria G. van; Mol, Ben Willem J.; Groot, Christianne de

doi:10.1016/j.preghy.2013.07.002

Cited by 9 publications

(8 citation statements)

References 22 publications

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“…The high prevalence of hypertension and hypercholesterolemia after HD in these women with inheritable thrombophilia is in line with other studies (8,26). The prevalence of metabolic syndrome after HD is higher in the present study compared with other studies where they describe prevalence between 14% and 25% (8,27).…”

Section: Discussionsupporting

confidence: 91%

“…The prevalence of metabolic syndrome after HD is higher in the present study compared with other studies where they describe prevalence between 14% and 25% (8,27). The difference of our study compared with the aforementioned studies is that women who participated in our study all had inheritable thrombophilia, were on average 10 years older at follow-up, and were examined after a longer time interval since pregnancy: the other studies examined women 0.5-2.5 years after pregnancy (8,26,27). Moreover, two of three studies did not include early-onset HD but late-onset HD only (26,27).…”

Section: Discussioncontrasting

confidence: 75%

“…Difference to our study is their age at follow-up; on average about 5 years younger compared with our population (28). Since we found equal prevalence of hypertension and hypercholesterolemia and a higher prevalence of metabolic syndrome compared with women with unknown thrombophilia status (8,(26)(27)(28), we could not support the finding that thrombophilia might mediate in lowering cardiovascular risk factors compared with women without thrombophilia (22). Moreover, the prevalences in the general Dutch female population in the age range of 40-49 years for hypertension (15%), hypercholesterolemia (17%), and metabolic syndrome (11%) are much lower compared with this study (29).…”

Section: Discussionmentioning

confidence: 78%

“…The difference of our study compared with the aforementioned studies is that women who participated in our study all had inheritable thrombophilia, were on average 10 years older at follow-up, and were examined after a longer time interval since pregnancy: the other studies examined women 0.5-2.5 years after pregnancy (8,26,27). Moreover, two of three studies did not include early-onset HD but late-onset HD only (26,27). The other study included women with either early-onset HD, late-onset HD, or pregnancy-induced hypertension (8).…”

Section: Discussionmentioning

confidence: 88%

See 3 more Smart Citations

Cardiovascular risk factors in women with inheritable thrombophilia a decade after single or recurrent hypertensive disorder of pregnancy

Abheiden

Thijs

Vries

et al. 2016

Hypertension in Pregnancy

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 88%

See 2 more Smart Citations

Cardiovascular risk factors in women with inheritable thrombophilia a decade after single or recurrent hypertensive disorder of pregnancy

Abheiden

Thijs

Vries

et al. 2016

Hypertension in Pregnancy

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“…In the Netherlands, CVD are the second largest cause of death for women (2). It is widely established that there is a correlation between hypertensive disorders of pregnancy (HDP, including pregnancy-induced hypertension and preeclampsia (3)) and developing risk factors for CVD later in life, such as hypertension, metabolic syndrome, hypercholesterolemia, diabetes mellitus (DM), and body mass index (BMI) > 25 kg/m2 (4)(5)(6)(7)(8)(9)(10)(11)(12). Within the group of women who develop HDP, some women are diagnosed with inheritable thrombophilia; a group of genetic disorders including: factor V Leiden (FVL), prothrombin gene G2021A mutation, protein C deficiency, protein S deficiency, and common polymorphisms (C677 T and A1298 C) of the gene for methylenetetrahydrofolate reductase (MTHFR) (13).…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular risk after hypertensive disorders of pregnancy in women with and without inheritable Thrombophilia

Schonewille¹,

Abheiden²,

Bokslag³

et al. 2020

Hypertension in Pregnancy

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Aim of this study was to compare cardiovascular risk in women with and without inheritable thrombophilia after hypertensive disorders of pregnancy (HDP). Blood pressure, anthropometrics and blood samples were measured 9-13 years after early-onset (<34 weeks) HDP. Amongst the 114 women included, no differences in hypertension (31.1% vs. 33.7%, OR 0.90 95% CI (0.29-2.79)), body mass index > 25 kg/m 2 (43.8% vs. 53.1%, OR 0.69 95% CI (0.24-2.00)) or metabolic syndrome (18.8% vs. 13.3%, OR 1.51 95% CI (0.38-6.02)) were found. These data show similar cardiovascular risk profile in women with and without inheritable thrombophilia.

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Patterns of Antihypertensive Medication Use in the First 2 Years Post Partum

Lihme,

Basit,

Thilaganathan

et al. 2024

JAMA Netw Open

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ImportanceWomen who had a hypertensive disorder of pregnancy (HDP) have a well-documented risk of chronic hypertension within a few years of delivery, but management of postpartum hypertension among these women remains inconsistent.ObjectiveTo assess the incidence of initiation of antihypertensive medication use in the first 2 years after delivery by HDP status and antenatal antihypertensive medication use.Design, Setting, and ParticipantsThis Danish register-based cohort study used data from women with at least 1 pregnancy lasting 20 or more gestational weeks (only the first pregnancy in the period was considered) who delivered from January 1, 1995, to December 31, 2018. Statistical analysis was conducted from October 2022 to September 2023.ExposureHypertensive disorders of pregnancy.Main Outcomes and MeasuresCumulative incidences and hazard ratios of initiating antihypertensive medication use within 2 years post partum (5 postpartum time intervals) by HDP status and antenatal medication use.ResultsThe cohort included 784 782 women, of whom 36 900 (4.7% [95% CI, 4.7%-4.8%]) had an HDP (HDP: median age at delivery, 29.1 years [IQR, 26.1-32.7 years]; no HDP: median age at delivery, 29.0 years [IQR, 25.9-32.3 years]). The 2-year cumulative incidence of initiating postpartum antihypertensive treatment ranged from 1.8% (95% CI, 1.8%-1.8%) among women who had not had HDPs to 44.1% (95% CI, 40.0%-48.2%) among women with severe preeclampsia who required antihypertensive medication during pregnancy. Most women who required postpartum antihypertensive medication after an HDP initiated use within 3 months of delivery (severe preeclampsia, 86.6% [95% CI, 84.6%-89.4%]; preeclampsia, 75.3% [95% CI, 73.8%-76.2%]; and gestational hypertension, 75.1% [95% CI, 72.9%-77.1%]). However, 13.4% (95% CI, 11.9%-14.1%) of women with severe preeclampsia, 24.7.% (95% CI, 24.0%-26.0%) of women with preeclampsia, 24.9% (95% CI, 22.5%-27.5%) of women with gestational hypertension, and 76.7% (95% CI, 76.3%-77.1%) of those without an HDP first filled a prescription for antihypertensive medication more than 3 months after delivery. Women with gestational hypertension had the highest rate of initiating medication after more than 1 year post partum, with 11.6% (95% CI, 10.0%-13.2%) starting treatment after this period. Among women who filled a prescription in the first 3 months post partum, up to 55.9% (95% CI, 46.2%-66.1%) required further prescriptions more than 3 months post partum, depending on HDP status and antenatal medication use.Conclusions and RelevanceIn this cohort study of postpartum women, the incidence of initiation of postnatal antihypertensive medication use varied by HDP status, HDP severity, and antenatal antihypertensive medication use. Up to 24.9% of women initiated antihypertensive medication use more than 3 months after an HDP, with up to 11.6% initiating treatment after 1 year. Routine postpartum blood pressure monitoring might prevent diagnostic delays in initiation of antihypertensive medication use and improve cardiovascular disease prevention among women.

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High blood pressure six weeks postpartum after hypertensive pregnancy disorders at term is associated with chronic hypertension

Cited by 9 publications

References 22 publications

Cardiovascular risk factors in women with inheritable thrombophilia a decade after single or recurrent hypertensive disorder of pregnancy

Cardiovascular risk factors in women with inheritable thrombophilia a decade after single or recurrent hypertensive disorder of pregnancy

Cardiovascular risk after hypertensive disorders of pregnancy in women with and without inheritable Thrombophilia

Patterns of Antihypertensive Medication Use in the First 2 Years Post Partum

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