High C-reactive protein instead of metabolic syndrome is associated with lower bioimpedance phase angle in individuals clinically screened for a lifestyle modification program

Moreto, Fernando; França, Natasha Aparecida Grande de; Gondo, Fernanda; Callegari, Aliucha; Corrente, José Eduardo; Burini, Roberto Carlos; Oliveira, Erick P. de

doi:10.1186/s41110-017-0043-0

Cited by 16 publications

(8 citation statements)

References 36 publications

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“…Similar to BP, we observed conflicting associations between raw bioelectrical impedance variables and blood lipids, as has been shown in previous studies (36,37). Under normal circumstances, HDL aids in maintaining the cell membrane through the prevention of cellular cholesterol toxicity (38), which occurs via HDL-mediated cholesterol efflux and inhibition of LDL oxidation (39).…”

Section: Discussionsupporting

confidence: 80%

Conflicting Associations among Bioelectrical Impedance and Cardiometabolic Health Parameters in Young White and Black Adults

GRAYBEAL,

BRANDNER,

STAVRES

2023

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose The purpose of this cross-sectional evaluation was to determine the associations between raw bioelectrical impedance and cardiometabolic health parameters in a sample of young non-Hispanic White and African-American adults. Methods A total of 96 (F: 52, M: 44) non-Hispanic White (n = 45) and African-American adults (n = 51) between the ages of 19 and 37 (22.7 ± 3.83 y) completed several fasted assessments including resting systolic blood pressure (rSBP), blood glucose (FBG), blood lipids, and bioelectrical impedance spectroscopy (BIS). BIS derived measurements included phase angle (PhA), bioimpedance index (BI), impedance ratio (IR), reactance index (XCi), fat-free mass (FFM), FFM index (FFMi), and absolute (a) and relative (%) total body water (TBW) and extra- (ECF) and intracellular fluid (ICF). All bioelectric variables were collected at 50 kHz other than IR (250 kHz/5 kHz). Multiple regressions were conducted and adjusted for sex, age, and BMI. Results rSBP was positively, and HDL was inversely, associated with all bioelectrical impedance and absolute hydration variables (all p ≤ 0.050) other than XCi for rSBP and XCi and FFMi for HDL. rSBP (p < 0.001) was inversely, and HDL (p = 0.034) was positively, associated with IR. FBG was positively associated with BI, XCi, FFM, TBWa, and ECFa (all p < 0.050). Metabolic syndrome severity was positively associated with BI, FFM, TBWa, and ECFa for females (all p ≤ 0.050) and with ICFa for African-American females (p = 0.016). Conclusions Given the rapid increase in the prevalence of cardiometabolic health risks among young adults and the broad use of bioelectrical impedance in practice, the conflicting associations we observed in this age group suggest that bioelectrical impedance parameters should be used with caution in the context of cardiometabolic health risks and age.

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Section: Discussionsupporting

confidence: 80%

Conflicting Associations among Bioelectrical Impedance and Cardiometabolic Health Parameters in Young White and Black Adults

GRAYBEAL,

BRANDNER,

STAVRES

2023

Medicine &Amp; Science in Sports &Amp; Exercise

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“…A Spanish study showed that low tertile of phase angle is a cardiovascular risk factor in obese patients [ 27 ]. Controversially, in our study, 50 kHz whole-body phase angle had a positive correlation with ALT, AST, ALP, and TG, as supported by a study done by Moreto et al It can be deduced that 50 kHz whole-body angle is an indicator of good nutritional status in a healthy population and is not a good predictor of MetS [ 28 ].…”

Section: Discussionsupporting

confidence: 75%

The Association between Anthropometry Indices and Serum Concentrations of Gamma-Glutamyl Transferase, Alkaline Phosphatase, Alanine Aminotransferase, and Aspartate Aminotransferase

Sobhani

Aryan

AkbariRad

et al. 2021

BioMed Research International

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Background. Nowadays, metabolic syndrome (MetS) has become a great public health crisis that threatens too many lives worldwide. Many previous studies have been investigated the association between MetS and anthropometric indices. This study is aimed at investigating the association between anthropometric indices with gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). We were using data from a large population-based cohort of seemingly healthy women and men. Methods. A total of 7216 participants were included in this study. The serum levels of GGT, ALP, ALT, and AST with bioimpedance measures were obtained at the time of enrollment. Multiple regression analysis was performed to assess the relationship between anthropometric indices and serum levels of the aforementioned laboratory tests. Results. Serum levels of GGT, ALP, ALT, and AST significantly correlated with body mass index (BMI). Only ALP had a significant association with visceral fat area (VFA). AST, ALT, and ALP levels had a positive correlation with 50 kHz whole-body phase. Conclusion. From the findings of this study, body mass index consistently appeared a good predictor of elevated hepatic enzymes and triglycerides. Thus, it can be helpful in clinical settings to identify patients at risk of nonalcoholic fatty liver disease, which is closely related to metabolic syndrome.

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“…As such, the use of PhA cut-offs values in this context are discouraged. Other studies confirmed negligible to moderate negative associations between PhA and CRP in adults, mostly with excess body weight [ 85 , 86 ]. These negative associations of similar strength between PhA and CRP were also found in clinical populations, including peritoneal dialysis [ 75 , 77 ], hospitalized patients (54.8% with malnutrition, and 34% with cancer) [ 39 ], psoriasis [ 81 ], Prader-Willi Syndrome [ 82 ], and COVID-19 [ 54 ].…”

Section: Phase Angle Inflammation and Cellular Damagementioning

confidence: 74%

“…Overall, PhA was associated with several direct inflammatory markers, such as CRP, TNF-α, IL-6, interleukin 1-β (IL-1β), interleukin-10 (IL-10), and indirect markers (i.e., malnutrition-inflammation score). Studies included patients with: chronic kidney disease [ 74 – 79 ], hospitalized [ 39 ], primary care [ 80 ], psoriasis [ 81 ], Prader–Willi Syndrome [ 82 ], COVID-19 [ 54 ]; additionally, studies also included older women [ 83 , 84 ], women with obesity [ 85 ], general population [ 86 , 87 ], and professional soccer players [ 88 ].…”

Section: Phase Angle Inflammation and Cellular Damagementioning

confidence: 99%

Phase angle and cellular health: inflammation and oxidative damage

Silva

Orsso

Gonzalez

et al. 2022

Rev Endocr Metab Disord

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Phase angle is a composite measure that combines two raw bioelectrical impedance analysis measures: resistance and reactance. Phase angle has been considered an indicator of cellular health, integrity, and hydration. As inflammation and oxidative stress can damage cellular structures, phase angle has potential utility in early detecting inflammatory and oxidative status. Herein, we aimed to critically review the current understanding on the determinants of phase angle and its relationship with markers of inflammation and oxidative stress. We also discussed the potential role of phase angle in detecting chronic inflammation and related adverse outcomes. Several factors have been identified as predictors of phase angle, including age, sex, extracellular to intracellular water ratio, and fat-free mass. In addition to these factors, body mass index (BMI) also seems to influence phase angle. Available data also show that lower phase angle values are correlated (negligible to high correlation coefficients) with higher c-reactive protein, tumour necrosis factor-α, interleukin-6, and interleukin-10 in studies involving the general and aging populations, as well as patients with chronic conditions. Although fewer studies have evaluated the relationship between phase angle and markers of oxidative stress, available data also suggest that phase angle has potential to be used as an indicator (for screening) of oxidative damage. Future studies including diverse populations and bioelectrical impedance devices are required to confirm the validity and accuracy of phase angle as a marker of inflammation and oxidative stress for clinical use.

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High C-reactive protein instead of metabolic syndrome is associated with lower bioimpedance phase angle in individuals clinically screened for a lifestyle modification program

Cited by 16 publications

References 36 publications

Conflicting Associations among Bioelectrical Impedance and Cardiometabolic Health Parameters in Young White and Black Adults

Conflicting Associations among Bioelectrical Impedance and Cardiometabolic Health Parameters in Young White and Black Adults

The Association between Anthropometry Indices and Serum Concentrations of Gamma-Glutamyl Transferase, Alkaline Phosphatase, Alanine Aminotransferase, and Aspartate Aminotransferase

Phase angle and cellular health: inflammation and oxidative damage

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