High cholesterol diet supplemented with sunflower seed oil but not olive oil stimulates lipid peroxidation in plasma, liver, and aorta of rats

Bulur, Hüseyi̇n; Özdemirler, Gül; Öz, Büğe; Toker, Gülçin; Öztürk, Muzaffer; Uysal, Müjdat

doi:10.1016/0955-2863(95)00099-l

Cited by 40 publications

(24 citation statements)

References 21 publications

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“…Although the precise mechanism by which cholesterol and LDL- cholesterol causes atherosclerosis has not yet been completely eluciated, it has been suggested that hypercholesterolemia and/or hypercholesterolemic atherosclerosis and lipid peroxidation play complementary roles in atherogenesis. 11,12,[33][34][35][36][37] Several studies suggest that oxidatively modified LDL plays an important role in the development of atherosclerosis by uptake via the macrophage scavenger receptor and foam cell formation. 38,39) Cholesterol feeding has often been used to elevate serum and tissue cholesterol levels, and rabbits are the animal most susceptible to the development of atherosclerosis via cholesterol feeding.…”

Section: Discussionmentioning

confidence: 99%

“…36) The literature related to atherosclerosis has emphasized the beneficial effects of MUFA containing oils, especially olive oil, on lipids and lipid peroxidation. 3,[9][10][11][12][13][14] But the effects of HO consumption on serum lipids and lipid peroxides are not clearly known. In our study, an HO diet given alone to normal rabbits did not affect plasma or tissue lipids, or prooxidant-antioxidant status.…”

Section: Discussionmentioning

confidence: 99%

“…7,8) On the other hand, monounsaturated fatty acids (MUFAs), like PUFAs, have been reported to have antilipidemic effects. 3,9) Since MUFAs are resistant to oxidation, they may lower the susceptibility of the organism to lipid peroxidation [9][10][11][12] and LDL oxidation. 13,14) Olive oil, which is rich in MUFAs, and is known as an antiatherogenic oil, has been gaining importance in nutrition.…”

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confidence: 99%

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Hazelnut Oil Administration Reduces Aortic Cholesterol Accumulation and Lipid Peroxides in the Plasma, Liver, and Aorta of Rabbits Fed a High-cholesterol Diet

Hatipoglu

Kanbagli

Balkan

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Hazelnut Oil Administration Reduces Aortic Cholesterol Accumulation and Lipid Peroxides in the Plasma, Liver, and Aorta of Rabbits Fed a High-cholesterol Diet

Hatipoglu

Kanbagli

Balkan

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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“…Increasing evidence shows a positive correlation between dietary saturated fat and plasma cholesterol. In addition, feeding cholesterol-rich diets induces free radical production, followed by oxidative stress and hypercholesterolemia, 1,2 and the added administration of antithyroid medication is known to augment atherogenesis. Oxidative stress, which results from impairment of the equilibrium between free radicals production and antioxidant defense systems, 3 is one of the causative factors that link hypercholesterolemia with atherogenesis.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of piperine, an alkaloidal constituent from Piper nigrum on erythrocyte antioxidant status in high fat diet and antithyroid drug induced hyperlipidemic rats

Vijayakumar

Nalini

2006

Cell Biochemistry & Function

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The main aim of this study was to investigate the effect of piperine on erythrocyte antioxidant status in high fat diet (HFD) and antithyroid drug induced hyperlipidemic rats. Male Wistar rats were divided into eight groups. The first four groups were fed a control diet and in addition were given respectively 1% carboxymethyl cellulose (CMC); 10 mg/kg body weight carbimazole (CM); 10 mg CM + 40 mg/kg body weight piperine and 10 mg CM + 2 mg/kg body weight atorvastatin (ATV). A similar pattern was followed for the next four groups except that they were all fed HFD instead of the control diet. Erythrocyte osmotic fragility, total cholesterol, phospholipids, lipid peroxidation products, enzymic and non-enzymic antioxidant status were studied in all experimental groups. Significantly increased osmotic fragility, total cholesterol/phospholipid ratio, thiobarbituric acid reactive substances and lipid hydroperoxides were observed in the plasma and erythrocytes of HFD fed and CM treated rats compared to the control. Superoxide dismutase, catalase, glutathione peroxidase, vitamin E and reduced glutathione in erythrocytes and vitamin C in the plasma were also significantly lowered in HFD fed, antithyroid drug treated rats compared to control animals. Concurrent piperine supplementation along with HFD and antithyroid drug administration normalized erythrocyte osmotic fragility, reduced lipid peroxidation, and improved the enzymic and non-enzymic antioxidant status compared to those rats that did not receive piperine. Thus, our results indicate that piperine supplementation markedly protects erythrocytes from oxidative stress by improving the antioxidant status in HFD fed antithyroid drug treated rats.

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“…Hyperlipidemia is considered to be a major risk factor for cardiovascular disease which has been an epidemic public and economic problem [6]. Recently, interests are focusing on the use of nonvitamin antioxidants such as flavonoids in reducing the negative effect of oxidative stress and free radicals in diabetic patients [7].…”

Section: Introductionmentioning

confidence: 99%

Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice

Li¹,

Kehui²,

Jiaoying³

et al. 2014

JFNR

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Aloe flavonoids exhibit various biological activities. The aim of this study was conducted to evaluate antioxidant activity and the hypolipemic mechanism of aloe flavonoids in mice. 80 hyperlipidemic mice were divided into 5 groups, each group was oral administrated with water, 4 mg/kg·BW simvastatin, 100, 200, 300 mg/kg·BW aloe flavonoids per day, respectively. Meanwhile, 16 normal mice were used as blank control, and oral administrated with water per day. After 8 weeks intervention, the concentrations of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) in the adipose and liver tissues were evaluated. Also, hormone-sensitive lipase (HSL), peroxisome proliferator-actived receptor gamma (PPAR-γ), adipose triacylglyceride lipase (ATGL), and fatty acid synthase (FAS) genes expressions in the two tissues were detected by Q-PCR. The results showed that aloe flavonoids could decrease the TC, TG levels in the adipose and liver, while the levels of T-AOC, CAT, GSH-Px were significanly increased when compared to the control group. After treating with aloe flavonoids, the gene expressions of HSL, PPARγ and ATGL expression enhanced, but the gene expression of FAS decreased when compared to the control group. In conclusion, our data showed that aloe flavonoids have potent hypolipemic and antioxidant activities.

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High cholesterol diet supplemented with sunflower seed oil but not olive oil stimulates lipid peroxidation in plasma, liver, and aorta of rats

Cited by 40 publications

References 21 publications

Hazelnut Oil Administration Reduces Aortic Cholesterol Accumulation and Lipid Peroxides in the Plasma, Liver, and Aorta of Rabbits Fed a High-cholesterol Diet

Hazelnut Oil Administration Reduces Aortic Cholesterol Accumulation and Lipid Peroxides in the Plasma, Liver, and Aorta of Rabbits Fed a High-cholesterol Diet

Efficacy of piperine, an alkaloidal constituent from Piper nigrum on erythrocyte antioxidant status in high fat diet and antithyroid drug induced hyperlipidemic rats

Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice

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