High-Concentration Nitrous Oxide for Procedural Sedation in Children: Adverse Events and Depth of Sedation

Babl, Franz E; Oakley, Ed; Seaman, Cameron; Barnett, Peter; Sharwood, Lisa N.

doi:10.1542/peds.2007-1044

Cited by 105 publications

(54 citation statements)

References 18 publications

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“…We did not perform any biopsy under general anesthesia. In different studies, it is noted that the majority of junior doctors, who are now trained in pediatric life, feel that short sedation is feasible and so the biopsies are easier to organize [12].…”

Section: Discussionmentioning

confidence: 99%

Results of native and transplant kidney biopsies of children in a single center over a 15 years period

et al. 2017

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Renal biopsy is an important diagnostic procedure in pediatric nephrology. This study retrospectively investigates the indications, results and complications in a single tertiary children's hospital in Turkey. We evaluated the native and transplant kidney biopsies in Gazi University Pediatric Nephrology Department between 2001 and 2015. A total of 196 biopsies (144 natives and 52 transplants) were included into the study. The mean age of the patients was respectively 10.8 ± 3.5, 13.9 ± 1.5 years. The main indication for a biopsy was non-nephrotic proteinuria with or without hematuria (n¼ 35), followed by steroid-resistance nephrotic syndrome (SRNS) (n ¼ 34) and Henoch-Sch€ onlein purpura (HSP)-related proteinuria (n ¼ 20) for native kidneys. We found that focal segmental glomerulosclerosis (FSGS) (11.7%) was the most common histopathologic diagnosis for native kidneys, but acute cellular rejection (7.6%) was the most common histopathologic diagnosis for transplant kidneys. The complication rate in our study was founded 6.6% totally. Different complication rates were found in other studies; however, we think that this difference comes from the inspecting methodology of the complications. Hence, we wanted to share our own experience in the context of other studies in the literature. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Results of native and transplant kidney biopsies of children in a single center over a 15 years period

et al. 2017

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“…One area of attention and contraindication is the patient with pneumothorax or pulmonary blebs (due to the risk of gas accumulation) [153]. Vomiting occurs uncommonly (about 5% rate) even in "high-dose" (70 : 30) N 2 O administration [154]; nausea without vomiting occurred only once in a recent prospective trial of 50 : 50 N 2 O use in the ED [155]. The risk of nausea/vomiting appears to be increased with use of higher concentrations of N 2 O or with combination therapy of N 2 O and an opioid such as fentanyl [156].…”

Section: Nitrous Oxide (N 2 O)mentioning

confidence: 99%

Management of Pain in the Emergency Department

Thomas

2013

ISRN Emergency Medicine

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Since pain is a primary impetus for patient presentation to the Emergency Department (ED), its treatment should be a priority for acute care providers. Historically, the ED has been marked by shortcomings in both the evaluation and amelioration of pain. Over the past decade, improvements in the science of pain assessment and management have combined to facilitate care improvements in the ED. The purpose of this review is to address selected topics within the realm of ED pain management. Commencing with general principles and definitions, the review continues with an assessment of areas of controversy and advancing knowledge in acute pain care. Some barriers to optimal pain care are discussed, and potential mechanisms to overcome these barriers are offered. While the review is not intended as a resource for specific pain conditions or drug information, selected agents and approaches are mentioned with respect to evolving evidence and areas for future research.

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“…Regarding the depth of sedation and incidence of adverse effects associated with inhalation of nitrous oxide in children 36 (B), it is known that high concentrations of the gas (70%) result in mild to moderate sedation with low occurrence of adverse effects, and that they safe for sedation and analgesia even in children under three years of age 36 (B). The occurrence of adverse effects -mostly vomiting -does not differ between the administration of nitrous oxide at 50% or 70%.…”

Section: Is the Use Of Nitrous Oxide A Safe Sedation And Analgesia Tementioning

confidence: 99%

“…The degree of sedation induced by nitrous oxide in children is mild and has a low frequency of adverse effects, which are mostly vomiting 36 (B).…”

Section: Recommendationmentioning

confidence: 99%

Uso do óxido nitroso em pediatria

Duarte

Neto²,

Mendes³

2012

Rev. Bras. Anestesiol.

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High-Concentration Nitrous Oxide for Procedural Sedation in Children: Adverse Events and Depth of Sedation

Abstract: In this largest prospective emergency department series, high-concentration continuous-flow nitrous oxide (70%) was found to be a safe agent for procedural sedation and analgesia when embedded in a comprehensive sedation program. Nitrous oxide also seems safe in children aged 1 to 3 years.

Cited by 105 publications

References 18 publications

Results of native and transplant kidney biopsies of children in a single center over a 15 years period

Results of native and transplant kidney biopsies of children in a single center over a 15 years period

Management of Pain in the Emergency Department

Uso do óxido nitroso em pediatria

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