High‐Contrast Fluorescence Diagnosis of Cancer Cells/Tissues Based on β‐Lapachone‐Triggered ROS Amplification Specific in Cancer Cells

Liu, Jing; Liu, Mengxing; Zhang, Hongxing; Guo, Wei

doi:10.1002/ange.202102377

Cited by 12 publications

(3 citation statements)

References 61 publications

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“…According to the above mechanism, the photo-oxidation of NADH by DA1 was evaluated. NADH, as an important coenzyme in many oxidoreductases, participates in the maintenance of the intracellular redox balance [52][53][54] . The oxidization of NADH in cancer cells would disturb the intracellular redox balance, thus leading to cell death [55][56][57] .…”

Section: Resultsmentioning

confidence: 99%

Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical

et al. 2022

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Given that Type-I photosensitizers (PSs) have hypoxia tolerance, developing general approaches to prepare Type-I PSs is of great importance, but remains a challenge. Here, we report a supramolecular strategy for the preparation of Type-I photodynamic agents, which simultaneously generate strong oxidizing cationic radicals and superoxide radicals, by introducing electron acceptors to the existing Type-II PSs. As a proof-of-concept, three electron acceptors were designed and co-assembled with a classical PS to produce quadruple hydrogen-bonded supramolecular photodynamic agents. The photo-induced electron transfer from the PS to the adjacent electron acceptor occurs efficiently, leading to the generation of a strong oxidizing PS+• and an anionic radical of the acceptor, which further transfers an electron to oxygen to form O2−•. In addition, these photodynamic agents induce direct photocatalytic oxidation of NADH with a turnover frequency as high as 53.7 min−1, which offers an oxygen-independent mechanism to damage tumors.

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Section: Resultsmentioning

confidence: 99%

Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical

et al. 2022

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“…NADH, as an important coenzyme in many oxidoreductases, participates in the maintenance of the intracellular redox balance. [53][54][55] The oxidization of NADH in cancer cells would disturb the intracellular redox balance, thus leading to cell death. 56,57 When NADH is oxidized to NAD + , the absorption at 339 nm is reduced and the absorption at 260 nm is enhanced (Fig.…”

Section: Resultsmentioning

confidence: 99%

Supramolecular Photodynamic Agents for Simultaneous Oxidation of NADH and Generation of Superoxide Radical

Teng

Niu

Xie

et al. 2022

Preprint

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Given that Type-I photosensitizers (PSs) have excellent hypoxia tolerance, developing general approaches to prepare Type-I PSs has the potential to advance the progress of photodynamic therapy (PDT), but remains a challenge. In this work, we report a supramolecular strategy for the preparation of Type-I photodynamic agents which simultaneously generate strong oxidizing cationic radicals of PS and superoxide radicals by introducing electron acceptors to the existing Type-II PSs. As a proof-of-concept, three electron acceptors were designed and co-assembled with a classical PS (iodide BODIPY) to produce quadruple hydrogen-bonded supramolecular photodynamic agents. The photo-induced electron transfer from the PS to the adjacent electron acceptor occurs efficiently, leading to the generation of a strong oxidizing PS+• and an anionic radical of the acceptor, which further transfers an electron to oxygen to form O2−•. Impressively, in addition to generating O2−• efficiently, these photodynamic agents induce direct photocatalytic oxidation of 1,4-dihydronicotinamide adenine dinucleotide (NADH) with a turnover frequency as high as 53.7 min-1 (1~3 orders of magnitude higher than those of conventional transition-metal catalysts), which offers an oxygen-independent mechanism to damage tumors. These photodynamic agents exhibit superior PDT performance even under hypoxic conditions. Distinct solid tumor ablation in vivo was also achieved in tumor treatment of mouse models. This work provides a new strategy and fresh insight on the design and development of Type-I photodynamic agents.

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“…The combination of PTX and CuB possessed improved inhibition of primary and metastatic breast cancers. The β -lapachone (Lap) also could generate ROS to trigger drug release 163 , 221 , 222 . Li et al.…”

Section: Ptx Nanodrugs For Tumor Therapy and Diagnosismentioning

confidence: 99%

Self-assembled nanoformulations of paclitaxel for enhanced cancer theranostics

Pei

Jiang

Hao

et al. 2023

Acta Pharmaceutica Sinica B

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High‐Contrast Fluorescence Diagnosis of Cancer Cells/Tissues Based on β‐Lapachone‐Triggered ROS Amplification Specific in Cancer Cells

Cited by 12 publications

References 61 publications

Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical

Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical

Supramolecular Photodynamic Agents for Simultaneous Oxidation of NADH and Generation of Superoxide Radical

Self-assembled nanoformulations of paclitaxel for enhanced cancer theranostics

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