High-Density Lipoprotein, Mean Platelet Volume, and Uric Acid as Biomarkers for Outcomes in Patients With Sepsis: An Observational Study

Montero-Chacón, Luis Bolívar; Padilla-Cuadra, Juan Ignacio; Chiou, Shyh‐Horng; Torrealba‐Acosta, Gabriel

doi:10.1177/0885066618772825

Cited by 21 publications

(26 citation statements)

References 35 publications

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“…The study by Guclu et al reported both on mortality and severity of disease and is therefore presented in both tables. 33 Seven studies were rated as good, 27,28,33,34,36,38,41 three fair/good, 35,39,40 three fair, 31,37,42 and one poor. 32 Detailed information on the rating of the 13 cohort studies is shown in ►Supplementary Table 1 (online only).…”

Section: Resultsmentioning

confidence: 99%

“…39,40 However, these findings were not supported by Sadaka et al, who reported MPV to have no predictive value of mortality in septic shock. 34 Overall mortality varied between studies; the majority of studies found rather low mortality at 8 to 16%, 27,28,34,36,38,41 whereas Sadaka et al reported mortality at 35% 30 and three studies reported mortality rates above 60%. 33,35,37 The different results across studies could be because of different disease severity at baseline indicated by diverse APACHE (Acute Physiology and Chronic Health Evaluation) scores across the study populations.…”

Section: Discussionmentioning

confidence: 99%

“…27,28,[35][36][37][38][39][40]42 Five of these studies reported increased immature platelets at admission in nonsurvivors compared with survivors, 27,28,[35][36][37] and four studies reported increased immature platelets in severe sepsis compared with nonsevere sepsis. [38][39][40]42 Two studies found no difference in immature platelets according to sepsis severity or mortality. 32,34 The results from the remaining three studies were ambiguous; Guclu et al reported a higher number of immature platelets in severe sepsis than in nonsevere sepsis but found no difference between survivors and nonsurvivors.…”

Section: Discussionmentioning

confidence: 99%

“…32,33,38 Among these, two studies were rated as good and found increased MPV to be associated with sepsis severity. 33,38 Montero-Chacón et al found increased MPV to be associated with an increased need for vasopressors and assisted mechanical ventilation and longer length of stay in ICU. 38 In contrast, Acikgoz et al demonstrated no difference in MPV between patients with or without DIC.…”

Section: Immature Platelets and Sepsis Severitymentioning

confidence: 99%

“…33,38 Montero-Chacón et al found increased MPV to be associated with an increased need for vasopressors and assisted mechanical ventilation and longer length of stay in ICU. 38 In contrast, Acikgoz et al demonstrated no difference in MPV between patients with or without DIC. 32 Two studies, rated as fair/good, reported that increased IPF discriminated between severe and nonsevere sepsis.…”

Section: Immature Platelets and Sepsis Severitymentioning

confidence: 99%

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Immature Platelets As a Predictor of Disease Severity and Mortality in Sepsis and Septic Shock: A Systematic Review

Thorup

Christensen

Hvas

2019

Semin Thromb Hemost

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Sepsis is associated with high morbidity and mortality, and short-term mortality remains above 30% despite relevant supportive and antibiotic treatments. The aim of this systematic review was to summarize and discuss the current evidence of the association of an increased number of circulating immature platelets with disease severity and mortality in patients with sepsis or septic shock. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and was registered at the PROSPERO database (registration number: CRD42018104326). A systematic literature search was performed in PubMed, Web of Science, Scopus, and Embase on June 20, 2018, without time restrictions. The included studies were quality-assessed by the National Institutes of Health's Quality Assessment Tools. In total, 14 studies were included. The parameters used for the determination of platelet maturity were mean platelet volume, immature platelets fraction, reticulated platelet percentage, and absolute immature platelets count. Nine studies reported significantly increased immature platelet markers in nonsurvivors of septic shock compared with survivors, as well as in patients with severe sepsis or septic shock compared with patients without severe sepsis and septic shock. Six of these nine studies demonstrated that increased immature platelet markers were predictors of mortality and/or disease severity (area under the receiver operating curve: 0.599–0.886). This review suggests that an increased number of circulating immature platelets is associated with increased disease severity and mortality in patients with sepsis and septic shock. Larger studies are needed to confirm whether immature platelets should be routinely monitored to support the prediction of disease severity and mortality in septic patients.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Immature Platelets and Sepsis Severitymentioning

confidence: 99%

Section: Immature Platelets and Sepsis Severitymentioning

confidence: 99%

See 3 more Smart Citations

Immature Platelets As a Predictor of Disease Severity and Mortality in Sepsis and Septic Shock: A Systematic Review

Thorup

Christensen

Hvas

2019

Semin Thromb Hemost

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Prognostic Significance of Plasma Insulin Level for Deep Venous Thrombosis in Patients with Severe Traumatic Brain Injury in Critical Care

Zhang

Tang

et al. 2022

Neurocrit Care

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Background:Whether insulin resistance is underlying the deep venous thrombosis (DVT) development in patients with traumatic brain injury (TBI) is elusive. To associate kinetics of plasma insulin level in patients with TBI with developing DVT in ICU. Methods:A prospective observational study of 73 patients with TBI who had measurements of insulin, glucose, glucagon-like peptide 1 (GLP-1), in ammatory factors, and hematological pro le within 4 preset time periods during the 14 days after TBI. Ultrasonic surveillance of DVT was tracked weekly for time-to-event analyses. Two-way ANOVA analysis was applied to determine whether the above factors could discriminate between patients with and without DVT, or with and without insulin therapy. Partial correlations of insulin level with all the variables were carried out separately in patients with or without DVT. Factors associated with DVT were analyzed by multivariable logistic regression. Neurological outcome 6 months after TBI was assessed for Glasgow Outcome Scale (GOS).Results:Among patients with an average (SD) age of 53±16 years, DVT developed in 20 (27%) on mean (median) TBI day 10±8. The 14-day insulin levels were higher in patients with DVT (P=0.01). Platelet pro le discriminated signi cantly between patients with and without DVT. Surprisingly, none of other factors differed between the two groups. Patients with insulin therapy had signi cant higher insulin (P=0.006), glucose (P<0.001) and GLP-1 (P=0.01) levels, and were more likely to develop DVT (60% vs. 15%, P<0.001) with concomitant platelet depletion. Insulin levels correlated with glucose, GLP-1 levels, and platelet count exclusively in patients without DVT. Conversely, in patients with DVT, insulin correlated negatively with GLP-1 level (r=-0.297, P=0.016). Age (P=0.01) and elevated insulin level at day 4-7 (P=0.04) were independently associated with DVT. Patients with insulin therapy also showed worse GOS (P=0.001). Conclusions:Elevated insulin level in the rst 14 days after TBI may present insulin resistance in TBI, which was associated with consistent platelet activation, thus increasing risk of DVT. Our data suggest that insulin resistance index may be a predictive biomarker for DVT.

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The pleiotropic effects of high-density lipoproteins and apolipoprotein A-I

Thomas

Zhang

Rye

2023

Best Practice & Research Clinical Endocrinology & Metab

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High-Density Lipoprotein, Mean Platelet Volume, and Uric Acid as Biomarkers for Outcomes in Patients With Sepsis: An Observational Study

Abstract: We were able to establish significant associations between our candidate biomarkers and relevant outcomes for patients with sepsis. Our results support the use of these low-cost biomarkers in the assessment of prognosis of patients with sepsis.

Cited by 21 publications

References 35 publications

Immature Platelets As a Predictor of Disease Severity and Mortality in Sepsis and Septic Shock: A Systematic Review

Immature Platelets As a Predictor of Disease Severity and Mortality in Sepsis and Septic Shock: A Systematic Review

Prognostic Significance of Plasma Insulin Level for Deep Venous Thrombosis in Patients with Severe Traumatic Brain Injury in Critical Care

The pleiotropic effects of high-density lipoproteins and apolipoprotein A-I

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