High-density lipoprotein subfractions and risk of coronary artery disease

Morgan, John; Carey, Christina; Lincoff, Anne; Capuzzi, David M.

doi:10.1007/s11883-004-0047-0

Cited by 65 publications

(53 citation statements)

References 45 publications

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“…While there were statistically significant decreases in body composition (body weight, BMI, percent body fat), none of these changes were significantly correlated with changes in HDL 2 -C. Thus, it appears that increases in HDL 2 -C as a result of aerobic exercise occur independent of changes in body weight. These findings are important because of the general belief that HDL 2 -C provides greater protection against CHD than HDL 3 -C [3]. In addition, the fact that we found statistically significant increases in HDL 2 -C but not HDL-C suggests that cardioprotective benefits can occur independent of changes in HDL-C.…”

Section: Discussionmentioning

confidence: 47%

“…The third report of the National Cholesterol Education Program Expert Panel on the Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) concluded that a low level of HDL-C is strongly and inversely related to coronary heart disease (CHD) [2]. Of the two major HDL-C subfractions, HDL 2 -C appears to provide greater protection against CHD than high-density lipoprotein three cholesterol (HDL 3 -C) [3].…”

Section: Introductionmentioning

confidence: 99%

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Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

Kelley

2006

Atherosclerosis

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Purpose-Use the meta-analytic approach to examine the effects of aerobic exercise on highdensity lipoprotein two cholesterol (HDL 2 -C) in adults.Study sources-(1) Computerized literature searches; (2) cross-referencing from retrieved articles; (3) hand-searching; and (4) expert review of our reference list.Study selection-(1) Randomized controlled trials; (2) aerobic exercise ≥8 weeks; (3) adults ≥18 years of age; (4) studies published in journal, dissertation, or master's thesis format; (5) studies published in the English-language between January 1, 1955 and January 1, 2003; and (6) assessment of HDL 2 -C in the fasting state.Data abstraction-All coding conducted by both authors, independent of each other. Discrepancies were resolved by consensus.Results-Nineteen randomized controlled trials representing 20 HDL 2 -C outcomes from 984 males and females (516 exercise, 468 control) were pooled for analysis. Using random-effects modeling and bootstrap confidence intervals (BCI), a statistically significant increase of approximately 11% was observed for HDL 2 -C (X̄ ± S.E.M., 2.6±0.9 mg/dl, 95% BCI, 1.0-4.4 mg/dl). With each study deleted from the model once, results remained statistically significant. Increases in HDL 2 -C were independent of decreases in body weight, body mass index (kg/m 2 ), and percent body fat.Conclusion-Aerobic exercise increases HDL 2 -C in adults.

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Section: Discussionmentioning

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

Kelley

2006

Atherosclerosis

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“…(37,38) Differences in distribution and size of HDL-P have been related to CVD risk. (39)(40)(41)(42)(43)(44)(45)(46) Whether there is a unique important protective effect of size of HDL-P measured by NMR spectroscopy requires better assessment of the characteristics and metabolism by size of HDL-P. (39) Large rather than small LDL-P were more strongly related to risk of CHD death for MRFIT men with MetSyn, especially among men without morbid CV events in the first 6 years of the trial. Recent reports from the MESA (36) and the VA-HIT trial (35) have shown that markers of LDL-P rather than size may be a more important determinant of the risk of CHD.…”

Section: Discussionmentioning

confidence: 99%

Lipoprotein particles, insulin, adiponectin, C-reactive protein and risk of coronary heart disease among men with metabolic syndrome

et al. 2007

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We tested the hypotheses whether nuclear magnetic resonance (NMR) determined lipoprotein particles, insulin and adiponectin, and C-reactive protein (CRP) and white blood cell (WBC) count as markers of inflammation predicted risk of coronary heart disease (CHD) death among 428 men age 35-57 years with metabolic syndrome (MetSyn) in a matched case control study within the Multiple Risk Factor Intervention Trial.Blood samples collected at entry into the study and stored at −60° C were obtained from central storage for blood analyte analysis. 214 men with MetSyn who died of CHD were matched with 214 men with MetSyn who did not die of CHD during 18 years of follow-up. Cases were matched to controls on age, study group, number of factors present in the MetSyn, and presence or absence of a non-fatal CVD event during the trial. Mortality follow up was determined using the National Death Index.Higher levels of high density lipoprotein particles (HDL-P), especially medium-sized HDL-P, [hazard ratio (95% confidence interval) 0.45 (0.25-0.83, p<0.01), quartile 1 as compared to quartile 4], were associated with lower risk of CHD death. Low density lipoprotein (LDL) particles were not associated with increased risk of CHD. Elevated LDL cholesterol (LDL-C), smoking and WBC count were, but levels of adiponectin, insulin and CRP were not significantly related to CHD death. In multivariate models adjusting for smoking and LDL-C, medium HDL-P and WBC count remained independent predictors of CHD death.Number of HDL particles, especially medium-sized HDL particles and WBC count were independent predictors of CHD death among men with MetSyn.

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“…Because the major role of HDL2-C appears to be as a final receptor in the reverse cholesterol transport process, increases in HDL2-C as a result of aerobic exercise occurred independently of changes in physical characteristics, and statistically significant increases were found in HDL2-C but not important in HDL-C 42) . In addition, of the two major HDL-C subfractions, HDL2-C may provide greater protection against CAD than HDL3-C 62) . Therefore, no increase in HDL-C in the clinical setting may not be indicative of a lack of cardioprotection within this lipoprotein group 42) .…”

Section: Effects Of Exercise On Hdls and Clinical Significancementioning

confidence: 99%

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Turgay

Şişman

Aksu

2015

JAT

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Aim: Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL). The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1), including basal PON1, salt-stimulated PON1 (SPON1), and arylesterase (AE) activities, of serum, HDL, and HDL subgroups (HDLs; HDL and its subgroups) and its relationship with PON1-Q192R phenotype (PON1P). Methods: Our study included 18 Turkish national female judoists (mean age: 17.9 0.8 years). Before and after 5 months of anaerobic training, critical speed (CS), TDPON1 activities, cholesterol levels in the serum and supernatants of HDLs obtained by polyethylene glycol, and other major blood lipids and lipoproteins (BLLPs) including triglycerides were determined using blood samples taken after overnight fasting. PON1P groups (PGs) were categorized as QQ (QG; persons with low activity) and R carriers (QR RR) (RG; persons with high activity) according to SPON1/AE activity ratios. The results were considered statistically significant at P ≤ 0.05. Results: Anaerobic training resulted in significantly increased the cholesterol levels of HDLs (except HDL2-C) in all subjects, but not HDLs-C in PGs. Anaerobic training resulted in significant increases in most TDPON1 activities of serum and HDLs in all subjects and (except AE) in PGs, whereas SPON1 and HDL2 AE activities increased only in the RG, which was related to PON1P. However, PON1P was not related to other measured markers, including basal BLLP profiles. Conclusions: Anaerobic training improved most TDPON1 activities of serum and HDLs and HDLs -C levels (except HDL2-C) in all subjects, but not HDLs-C in PGs. The beneficial effects of anaerobic training on SPON1 and HDL2 AE activities were depend on PON1P. The lack of response of HDL2-C to anaerobic exercise will require further research. J Atheroscler Thromb, 2015; 22: 313-326.

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High-density lipoprotein subfractions and risk of coronary artery disease

Cited by 65 publications

References 45 publications

Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

Lipoprotein particles, insulin, adiponectin, C-reactive protein and risk of coronary heart disease among men with metabolic syndrome

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

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