High-density lipoproteins (HDL) composition and function in preeclampsia

Einbinder, Yael; Biron‐Shental, Tal; Agassi-Zaitler, Moran; Tzadikevitch‐Geffen, Keren; Vaya, Jacob; Khatib, Soliman; Ohana, Meital; Benchetrit, Sydney; Zitman‐Gal, Tali

doi:10.1007/s00404-018-4824-3

Cited by 23 publications

(17 citation statements)

References 47 publications

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“…Thus, practical laboratory markers which can help in assessing the onset and severity of PE remain to be studied. In recent years, an increasing number of studies are giving attentions to the correlation between serum markers and severity of PE [30][31][32]. Soluble endoglin and soluble fms-like tyrosine kinase-1 [16], serum ceruloplasmin [21], and soluble LIGHT [22] in the early phrase of pregnancy are often reported to have possible value in PE prediction.…”

Section: Discussionmentioning

confidence: 99%

Alterations of Several Serum Parameters Are Associated with Preeclampsia and May Be Potential Markers for the Assessment of PE Severity

Duan

Leung

et al. 2020

Disease Markers

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The precise pathophysiological mechanisms of preeclampsia (PE) and preventative strategies remain unknown. Laboratory markers which can help in identifying PE patients from pregnant women and assessing the severity of PE during pregnancy are worthy to be explored. In this study, a retrospective case-control study was designed to assess whether the serum levels of albumin (ALB), total protein (TP), prealbumin (PA), alkaline phosphatase (ALP), lactic dehydrogenase (LDH), D-dimer, fibrinogen (Fbg), platelet (PLT) count, mean platelet volume (MPV), and platelet distribution width (PDW) can help in assessing PE and evaluate its severity. 256 pregnant women were enrolled and classified into 3 groups: mild preeclampsia (mPE, n = 85), severe preeclampsia (sPE, n = 78), and healthy normotensive controls (control, n = 93). Our result showed that the serum levels of ALP, LDH, and D-dimer were significantly higher in mild or severe PE patients compared with the healthy controls (66 (52.

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Section: Discussionmentioning

confidence: 99%

Alterations of Several Serum Parameters Are Associated with Preeclampsia and May Be Potential Markers for the Assessment of PE Severity

Duan

Leung

et al. 2020

Disease Markers

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“…PON1 is associated with a specific HDL subspecies and has a major role in the antioxidative activity of HDL [12]. In a recent study [8], we demonstrated that HDL from women with pre-eclampsia have decreased PON1 activity and increased APOA1 release. In the present study, we found similar patterns in APOA1 released from GDMA2-HDL.…”

Section: Discussionmentioning

confidence: 71%

“…PON1 is associated with a specific HDL subspecies and has a major role in the antioxidative activity of HDL [12]. In a recent study [8], we demonstrated that HDL from women with pre-…”

Section: Discussionmentioning

confidence: 80%

“…As described in the Methods Section 4.5 HDL Assays and Electrophoresis, 4-12% gradient PAGE was used to separate 20 µg of isolated HDL. HDL diameter was analyzed using multi gauge analysis software (Fujifilm) [8]. Briefly, the HDL band was divided into 2 sections (a and b in Figure 1A) by a horizontal line exactly in the middle of the control HDL.…”

Section: Changes Observed In Gdma2 Hdl Composition Apoa1 and Pon1 Exmentioning

confidence: 99%

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Gestational Diabetes Type 2: Variation in High-Density Lipoproteins Composition and Function

Pasternak

Biron‐Shental

Ohana

et al. 2020

IJMS

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Aims: Class A2 gestational diabetes mellitus (GDMA2) has short- and long-term effects on the mother and child. These may include abnormalities of placentation, damage to endothelial cells and cardiovascular disease. This research investigated the function and composition of high-density lipoproteins (HDL) among women with GDMA2 and their fetuses. Methods: Thirty pregnant women were recruited during admission for delivery. The function and expression of HDL, paraoxonase1 (PON1) and apolipoprotein A1 (APOA1) in the blood samples and the placental tissue were evaluated. The effect of HDL on migration of endothelial cells was measured in vitro. Results: Compared to normal pregnancy (NP), APOA1 in the maternal plasma of women with GDMA2 was decreased. More APOA1 and PON1 were released from HDL of women with GDMA2, compared to NP. Placental APOA1 and PON1 were decreased in GDMA2. For endothelial cells stimulated with TNFα, HDL cell migration was decreased when cells were evaluated with NP-HDL, as compared to GDMA2-HDL. Conclusions: GDMA2 affects the composition and function of HDL in plasma. Changes in HDL commonly seen in GDMA2 were observed in maternal and placental samples, but not in cord samples. These results might indicate a placental role in protecting the fetus by preserving the components and functions of HDL and require further investigation.

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“…Several studies have suggested that apolipoproteins can participate in carcinogenesis by promoting proliferation and invasion, enhanced antitumor immunity or drug delivery, and an immediate oxidative stress reaction [11][12][13][14][15][16]. Apolipoprotein A-I (ApoA-I), mainly synthesized in the liver and the small intestine, is a major fraction of HDL-C, accounting for approximately 70% [17,18]. In CRC patients, the serum ApoA-I level has been reported to be an independent prognostic indicator to predict chemotherapy efficacy and survival time [19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of the serum apolipoprotein B to apolipoprotein A-I ratio in metastatic colorectal cancer patients

et al. 2020

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Background:The aim of our research was to assess the prognostic value of the apolipoprotein B (ApoB) to apolipoprotein A-I (ApoA-I) ratio (ApoB/ApoA-I) in metastatic colorectal cancer (mCRC) patients. Methods: We randomly assigned 838 patients into the training cohort (n=578) and the validation cohort (n=260). The cut-off value of the ApoB/ApoA-I in the training cohort identified by a receiver operating characteristic (ROC) curve was 0.69 and was further validated in the validation cohort. A propensity score matching (PSM) analysis was carried out to eliminate the imbalance in the baseline characteristics of the high and low ApoB/ApoA-I group. The PSM cohort of 542 mCRC patients was generated. We also validated our main findings and conclusions with an independent cohort (n=150). Univariate and multivariate analyses were conducted to explore the independent prognostic value of the ApoB/ApoA-I in the training cohort (n=578), the validation cohort (n=260), the PSM cohort (n=542) and the independent cohort (n=150). Results: Patients in the high ApoB/ApoA-I group had significantly shorter overall survival compared to those in the low ApoB/ApoA-I group in the training cohort, the validation cohort, the PSM cohort and the independent cohort (P <0.01). Multivariate analysis indicated that the ApoB/ApoA-I was an independent prognostic index for OS in the training cohort [hazard ratio (HR):1.371; 95% confidence interval (CI):1.205-1.870, P=0.045], the validation cohort (HR: 1.924; 95% CI: 1.360-2.723, P<0.001), the PSM cohort (HR: 1.599; 95% CI: 1.287-1.988, P<0.001) and the independent cohort (HR: 1.949; 95% CI: 1.014-3.747, P=0.046). Conclusions: An increased baseline serum ApoB/ApoA-I is an independent prognostic factor for a poor prognosis in mCRC patients.

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High-density lipoproteins (HDL) composition and function in preeclampsia

Abstract: HDL from women with PE reduced PON1 activity and increased ApoA1 release from HDL particles. This process was associated with increased HDL diameter, suggesting impaired HDL anti-oxidant activity. These changes might contribute to higher long-term cardiovascular risks among women with PE.

Cited by 23 publications

References 47 publications

Alterations of Several Serum Parameters Are Associated with Preeclampsia and May Be Potential Markers for the Assessment of PE Severity

Alterations of Several Serum Parameters Are Associated with Preeclampsia and May Be Potential Markers for the Assessment of PE Severity

Gestational Diabetes Type 2: Variation in High-Density Lipoproteins Composition and Function

Prognostic value of the serum apolipoprotein B to apolipoprotein A-I ratio in metastatic colorectal cancer patients

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