High-density Si nanopillars modified with Ag nanoislands: Sensitive SALDI-MS chip for sulfonamides

Dou, Shuzhen; Lu, Jie; Chen, Qiye; Chen, Chunning; Lü, Nan

doi:10.1016/j.snb.2022.131846

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…Shortly after the development of MALDI ionization, several researchers tested the possibility of using different nanoparticles as alternative matrices to conventional ones. − Carbon-based nanoparticles, silicon-based nanoparticles, metallic nanoparticles, and their combinations (i.e., hybrid matrices) are among the main groups of nanosized matrices. − In this paper, we reviewed in detail carbon-based matrices and their derivatives, and here we briefly compare other nanoparticles utilized as MALDI matrices to carbon-based ones.…”

Section: Carbon-based Nanoparticles In Comparison With Other Nanopart...mentioning

confidence: 99%

Carbon-Based Nanoparticles and Their Surface-Modified Counterparts as MALDI Matrices

Khajavinia

El‐Aneed

2023

Anal. Chem.

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Section: Carbon-based Nanoparticles In Comparison With Other Nanopart...mentioning

confidence: 99%

Carbon-Based Nanoparticles and Their Surface-Modified Counterparts as MALDI Matrices

Khajavinia

El‐Aneed

2023

Anal. Chem.

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“…Due to these many advantages, SALDI MS is developing rapidly, and has for example recently been used to visualize phospholipids in cancerous tissues in the perspective of cancer diagnosis [42], to analyze poisons in human serum [43], and to detect drugs in environmental samples [44]. However, the implementation of this novel ionization technique introduces new challenges, which include the understanding of the fundamental mechanisms that govern the SALDI process, and the optimization of the experimental factors.…”

Section: Saldi Mass Spectrometrymentioning

confidence: 99%

Optimisation de la spectrométrie de masse par désorption/ionisation laser assistée par surface : la quête du Saint Graal basée sur l'étude des ions thermomètres.

Müller¹

2022

Bull. Soc. R. Sci. Liege

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In recent years, there has been a growing interest in the study of small molecules (e.g. metabolites, lipids, drugs) as they play important roles in various research areas, including biomedicine, biotechnology, environmental science and drug discovery. Mass spectrometry (MS) has become a predominant technology to analyze these low molecular weight compounds. However, the analysis of small molecules by the established matrix-assisted laser desorption/ionization (MALDI) MS technique can be difficult because of the interference generated by the matrix in the low m/z range. Therefore, new innovating ionization techniques that do not require an organic matrix have been developed. Among these alternatives is surface-assisted laser desorption/ionization (SALDI) MS, which relies on nanostructured surfaces to promote the desorption/ionization process. Yet, the implementation of this novel ionization technique introduces new challenges, which include the understanding of the fundamental mechanisms that govern the SALDI process, and the optimization of the experimental factors. In particular, the design and optimization of the assisting nanosubstrates are not straightforward, because of the wide range of available nanomaterials (in terms of chemical nature and morphology), characterized by different properties, which impact the performance of the SALDI MS experiments. Thus, it is essential to find a model to compare the capabilities of the SALDI nanosubstrates, in order to optimize their characteristics based on the same reference. In this context, thermometer ions have been used as reference compounds to test novel instrumentation, new methodologies, or to tune instruments. In this article, we review the study of thermometer ions in SALDI MS, which have enabled to rationalize the effect of the experimental factors (i.e. the nanosubstrate morphology and chemical nature, and the instrumental settings) on the performance of SALDI MS experiments. These studies allow the rational design of optimized nanosubstrates for advanced applications, such as SALDI MS imaging, which will be discussed at the end of this article.

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Food safety evaluation: chemical

Sun,

2025

Utilizing Microfluidics in the Food Industry

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High-density Si nanopillars modified with Ag nanoislands: Sensitive SALDI-MS chip for sulfonamides

Cited by 6 publications

References 31 publications

Carbon-Based Nanoparticles and Their Surface-Modified Counterparts as MALDI Matrices

Carbon-Based Nanoparticles and Their Surface-Modified Counterparts as MALDI Matrices

Optimisation de la spectrométrie de masse par désorption/ionisation laser assistée par surface : la quête du Saint Graal basée sur l'étude des ions thermomètres.

Food safety evaluation: chemical

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