This study is focused on the multivariable, nonlinear, strong‐coupling, and time‐varying characteristics of the quality control process of hot strip rolling. Using the rolling process data from a continuously variable crown (CVC) mill of a 1580 mm hot tandem rolling line, a new prediction model of the strip thickness, profile, and flatness in hot rolling based on rolling mechanism model‐guided machine learning (ML) is developed. The weighted processing (WP) method is used to fuse the rolling mechanism and process data, to improve the relationship between the strong correlation features and the model. Combined with nondominated sorting genetic algorithm III (NSGA‐III), multiple parameters of multioutput support vector regression (M‐SVR) are optimized. The results show that the root mean square error (RMSE), mean square correlation coefficient (R
2), and mean absolute error (MAE) of the strip thickness, crown, and flatness are 2.0159, 1.3191, and 0.9355; 0.9854, 0.9895, and 0.9873; and 16.601, 1.126, and 0.604, respectively. Moreover, the established method of data fusion rolling mechanism shows strong capability to improve the model prediction accuracy, increasing it by 60%. Thus, it can offer theoretical guidance for realizing accurate control of the quality of strips and improving the quality of hot‐rolled products.