High dose ascorbate supplementation fails to affect plasma homocyst(e)ine levels in patients with coronary heart disease

Bostom, Andrew G.; Yanek, Lisa R.; Hume, Anne L.; Eaton, Charles B.; McQuade, William; Nadeau, Marie; Perrone, Gayle; Jacques, Paul F.; Selhub, Jacob

doi:10.1016/0021-9150(94)90101-5

Cited by 14 publications

(22 citation statements)

References 20 publications

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“…Our intervention study showed that a moderate amount of mixed antioxidants given to smokers, who are known to have low plasma concentrations of vitamin C [36], had no effect on the plasma homocysteine concentration. Previously, a high dose of ascorbate (4.5 g per day) failed to reduce the plasma homocysteine concentration in patients with coronary heart disease [37].…”

Section: Discussionmentioning

confidence: 99%

Plasma homocysteine concentration related to diet, endothelial function and mononuclear cell gene expression among male hyperlipidaemic smokers

Brude

Finstad

Seljeflot

et al. 1999

Eur J Clin Investigation

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The plasma homocysteine level was negatively correlated with dietary intake of vegetables, including vitamins C and E, and serum omega-3 fatty acids, whereas supplementation with antioxidants or omega-3 fatty acids did not affect plasma homocysteine concentration. Homocysteine was not associated with circulating adhesion molecules or increased procoagulant activity, but homocysteine may alter mononuclear cell gene expression. Cysteine showed no significant correlation with these parameters.

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Section: Discussionmentioning

confidence: 99%

Plasma homocysteine concentration related to diet, endothelial function and mononuclear cell gene expression among male hyperlipidaemic smokers

Brude

Finstad

Seljeflot

et al. 1999

Eur J Clin Investigation

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“…For the crossover trials, most reported the washout period used (range 2e4 weeks) while three studies did not report this information [29,38,40]. Only one study reported the use of lipid-lowering agents during the intervention period by some of the included participants [12].…”

Section: Characteristics Of the Studiesmentioning

confidence: 97%

“…3 on the Jadad scale (Table 1). Four studies described the method of randomization [12,26,34,35] and two studies stated the methods of allocation concealment [26,35]. For the crossover trials, most reported the washout period used (range 2e4 weeks) while three studies did not report this information [29,38,40].…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…Furthermore, human observational studies showed that high plasma concentrations of vitamin C are associated with more favourable lipid profiles [5,11]. However, RCTs have produced contradictory results about the effect of vitamin C supplementation on blood lipids [12,13] and there is no evidence from RCTs that supplemental vitamin C reduces CVD risk [14]. A previous meta-analysis of 13 trials which recruited participants with hypercholesterolaemia showed that vitamin C supplementation reduced concentrations of LDL-C and triglycerides significantly with no significant effect on HDL-C concentration [8].…”

Section: Introductionmentioning

confidence: 99%

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Systematic review and meta-analysis of randomised controlled trials testing the effects of vitamin C supplementation on blood lipids

et al. 2016

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“…However, in subjects with normal levels of ascorbic acid and cholesterol, there seems to be little effect of ascorbic acid [44, 45]. In a randomized placebo‐controlled trial, supplementation of a high dose of ascorbic acid (4.5 g day –1 ) during 12 weeks did not effect lipoprotein(a) levels [46].…”

Section: Intermediary End‐pointsmentioning

confidence: 99%

Antioxidant vitamins in the prevention of cardiovascular disease: a systematic review

Asplund

2002

Journal of Internal Medicine

191

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. Asplund K (Umeå and Stockholm, Sweden). Antioxidant vitamins in the prevention of cardiovascular disease: a systematic review (Review). J Intern Med 2002; 251: 372–392. Do antioxidant vitamins, in regular food or as food supplements, protect against myocardial infarction and stroke? In this systematic literature review on the effects of antioxidant vitamins in the primary prevention of cardiovascular disorders, studies with ischaemic heart disease, stroke or combined cardiovascular events as end‐points have been included. Studies on the effects of antioxidant vitamins on intermediary end‐points (such as blood lipids and blood pressure) and as secondary prevention in patients with manifest cardiovascular disease are reviewed in a conventional manner. In observational studies (case–control or cohort design), people with high intake of antioxidant vitamins by regular diet or as food supplements generally have a lower risk of myocardial infarction and stroke than people who are low‐consumers of antioxidant vitamins. The associations in observation studies have been shown for carotene, ascorbic acid as well as tocopherol. In randomized controlled trials, however, antioxidant vitamins as food supplements have no beneficial effects in the primary prevention of myocardial infarction and stroke. Serious adverse events have been reported. After an initial enthusiasm for antioxidants in the secondary prevention of cardiovascular disease, recent reports from of several large randomized trials have failed to show any beneficial effects. Thus, the apparent beneficial results of high intake of antioxidant vitamins reported in observational studies have not been confirmed in large randomized trials. The discrepancy between different types of studies is probably explained by the fact that supplement use is a component in a cluster of healthy behaviour. Antioxidant vitamins as food supplements cannot be recommended in the primary or secondary prevention against cardiovascular disease.

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High dose ascorbate supplementation fails to affect plasma homocyst(e)ine levels in patients with coronary heart disease

Cited by 14 publications

References 20 publications

Plasma homocysteine concentration related to diet, endothelial function and mononuclear cell gene expression among male hyperlipidaemic smokers

Plasma homocysteine concentration related to diet, endothelial function and mononuclear cell gene expression among male hyperlipidaemic smokers

Systematic review and meta-analysis of randomised controlled trials testing the effects of vitamin C supplementation on blood lipids

Antioxidant vitamins in the prevention of cardiovascular disease: a systematic review

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