High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents and young adults with first recurrence of Ewing sarcoma

Haveman, Lianne M.; Breunis, Willemijn B.; Dalen, Elvira C. van; Kremer, Leontien; Jürgens, Heribert; Dirksen, Uta; Berg, Henk van den; Merks, Johannes H. M.

doi:10.1002/14651858.cd011406

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…In those patients who present with pulmonary metastases, the 2- to 10-year event-free survival lies around 30–36% within the European Intergroup Cooperative Ewing and Paediatric Oncology Group studies [ 17 ]. Multivariable analysis of the European EURO-E.W.I.N.G.-99 trial (EUROpean Ewing tumour Working Initiative of National Groups-Ewing Tumour Studies 1999), on patients with primary disseminated multifocal Ewing sarcoma, identified several factors that significantly correlate with a worse outcome: patient age of more than 14 years at diagnosis, initial tumor volume of ≥200 mL, bone marrow metastases, and additional lung metastases [ 18 , 55 ]. Adverse clinical prognostic factors for patients with non-metastatic Ewing sarcoma are the site of the primary tumor (with axially located tumors with a poorer prognosis), poor histological response after neoadjuvant (radio-)chemotherapy (10% or greater viable tumor cells), and elevated serum lactate dehydrogenase levels [ 55 , 56 , 57 ].…”

Section: Ewing Sarcomamentioning

confidence: 99%

“…Adverse clinical prognostic factors for patients with non-metastatic Ewing sarcoma are the site of the primary tumor (with axially located tumors with a poorer prognosis), poor histological response after neoadjuvant (radio-)chemotherapy (10% or greater viable tumor cells), and elevated serum lactate dehydrogenase levels [ 55 , 56 , 57 ]. Besides patient characteristics, the success of the local tumor therapy affects the global outcome [ 55 , 58 ]. About 26% of primary tumors are located in the pelvis [ 57 , 59 ].…”

Section: Ewing Sarcomamentioning

confidence: 99%

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Surgical Treatment of Bone Sarcoma

Bläsius

Delbrück

Hildebrand

et al. 2022

Cancers

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Bone sarcomas are rare primary malignant mesenchymal bone tumors. The three main entities are osteosarcoma, chondrosarcoma, and Ewing sarcoma. While prognosis has improved for affected patients over the past decades, bone sarcomas are still critical conditions that require an interdisciplinary diagnostic and therapeutic approach. While radiotherapy plays a role especially in Ewing sarcoma and chemotherapy in Ewing sarcoma and osteosarcoma, surgery remains the main pillar of treatment in all three entities. After complete tumor resection, the created bone defects need to be reconstructed. Possible strategies are implantation of allografts or autografts including vascularized bone grafts (e.g., of the fibula). Around the knee joint, rotationplasty can be performed or, as an alternative, the implantation of (expandable) megaprostheses can be performed. Challenges still associated with the implantation of foreign materials are aseptic loosening and infection. Future improvements may come with advances in 3D printing of individualized resection blades/implants, thus also securing safe tumor resection margins while at the same time shortening the required surgical time. Faster osseointegration and lower infection rates may possibly be achieved through more elaborate implant surface structures.

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Section: Ewing Sarcomamentioning

confidence: 99%

Section: Ewing Sarcomamentioning

confidence: 99%

Surgical Treatment of Bone Sarcoma

Bläsius

Delbrück

Hildebrand

et al. 2022

Cancers

View full text Add to dashboard Cite

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High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with first recurrence of Ewing sarcoma

Haveman

Ewijk

Dalen

et al. 2021

Cochrane Database of Systematic Reviews

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Primary mediastinum Ewing’s sarcoma with pleural effusion: A case report and literature review

Zhu

et al. 2023

Open Life Sciences

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Ewing’s sarcoma (ES) is an aggressive cancer in young adults. Primary ES occurring in the chest with pleural effusion is even rarer. We report the case of a 15-year-old girl who presented with intermittent chest pain occurring for more than 2 months and cough and wheezing for 10 days. Radiological imaging showed a large soft tissue mass with multiple small vessel shadows near the left mediastinum and bloody pleural effusion in the left thorax. ES was diagnosed by positive immunostaining for CD99, FLI-1, and NKX2 combined with fluorescence in situ hybridization detection of the EWSR1 gene arrangement. With chemotherapy, lung computed tomography revealed that the tumor had become much smaller, and the fluid was absorbed. We report a case of extraskeletal Ewing’s sarcoma (EES) in the mediastinum with pleural effusion, which is unusual and challenging. EES is a highly malignant tumor with a poor prognosis. Early diagnosis and treatment can improve the survival rate of patients.

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High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents and young adults with first recurrence of Ewing sarcoma

Abstract: High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with first recurrence of Ewing sarcoma

Cited by 3 publications

References 19 publications

Surgical Treatment of Bone Sarcoma

Surgical Treatment of Bone Sarcoma

High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with first recurrence of Ewing sarcoma

Primary mediastinum Ewing’s sarcoma with pleural effusion: A case report and literature review

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