High-dose chlorogenic acid induces inflammation reactions and oxidative stress injury in rats without implication of mast cell degranulation

Chlorogenic Acid Combined with Lactobacillus plantarum 2142 Reduced LPS-Induced Intestinal Inflammation and Oxidative Stress in IPEC-J2 Cells

“…Still, it is important to examine the impact of chlorogenic acid on IPEC-J2 cells, because of its possible pro-oxidant effect. High-dose chlorogenic acid (7 mg/kg BW) increased the generation of peroxides in the venular walls in rats, moreover, an increase in maleic dialdehyde, myeloperoxidase, inflammatory cytokines and NADPH oxidase activities could be also observed [34]. In the same study, low-dose chlorogenic acid treatment did not affect negatively the redox state of animals.…”

Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1α/AKT pathway

“…coffee, potatoes and apples, and natural products containing CGA have widely been used for the treatment of inflammation [9][10][11] . CGA exerts diverse biological activities, including anti-inflammatory, anti-oxidative and anti-neurotoxic activities [12][13][14][15]. Until now, the role of CGA in angiogenesis and tumorigenesis has largely remained unknown.…”

Effect of Short-term Polyphenol Treatment on Endothelial Dysfunction and Thromboxane A₂ Levels in Streptozotocin-Induced Diabetic Mice

“…CA is a widely distributed phenolic acid present in coffee and some fruits, and it is known as a water-soluble antioxidant, and it has been successfully encapsulated in low-cost, high-volume yeast cells for the first time. [20][21][22][23] MO is a flavonoid found in figs and other Moraceae, which are used as herbal medicines, and it is known as a major lipid-soluble antioxidant. [22][23][24] RV is a naturally occurring polyphenolic phytoalexin found in many plants and contained in foods and drinks such as in Mediterranean diets and French wine, and it is known as a poor water-soluble antioxidant.…”