High Dose Isoflavones Do Not Improve Metabolic and Inflammatory Parameters in Androgen Deprived Men with Prostate Cancer.

Abstract

Background-The profound hypogonadism that occurs with androgen-deprivation therapy (ADT) for prostate cancer (PCa) results in complications such as diabetes and metabolic syndrome that predispose to cardiovascular disease. Since phytoestrogens have been associated with an improvement in metabolic parameters, we evaluated their role in men undergoing ADT. Objective-To evaluate the effects of high-dose isoflavones on metabolic and inflammatory parameters in men undergoing ADT. Methods-This was a randomized, double-blind, placebo-controlled, 12-week pilot study. Participants were randomly assigned to receive 20 g of soy protein containing 160 mg of total isoflavones vs taste-matched placebo (20 g whole milk protein). The study was conducted at a tertiary care center in the United States. Results-Thirty-three men (isoflavones=17, placebo=16) undergoing ADT for PCa completed this pilot study. Mean age in the two groups was 69 years and majority of men were Caucasians. Mean duration of ADT in both groups was approximately 2 years (P=0.70). The two groups were well-matched at baseline. After 12-weeks of intervention, there was no significant difference in either metabolic or inflammatory parameters between the two groups. Conclusion-High-dose isoflavones over a course of 12-weeks do not improve metabolic or inflammatory parameters in androgen deprived men.

The effect of soy and soy product supplementation on circulating adiponectin and leptin concentration: A systematic review and meta‐analysis of randomized controlled trials

“…The total number of participants who completed the studies in inclusion criteria was 511 participants in the intervention and 531 in the placebo groups for adiponectin and 544 participants in the intervention and 529 in the placebo groups for leptin. Soy protein have been used in a variety of forms in these studies like soy-based meal replacement [18][19][20]25,26,35,36 , soy powder or formula [15][16][17]21,22,24,27,37 and capsule supplement 19,23,38 . However most of studies have been used soy powder or formula.…”

“…Three studies used a randomized crossover design 18,24,27 , two of them was also single blind 18,27 and the other study had the design of double-blind 24 . Among 18 studies 9 studies were conducted in n the United States 15,[18][19][20][21]24,25,27,36 . The effect of soy protein on both adiponectin and leptin concentration was examined in 10 studies; and 4 studies only reported adiponectin 17,18,25,38 and 4 studies only reported leptin [35][36][37]39 .…”

“…However, some experimental studies have reported beneficial anti-inflammatory effects of soya protein or isoflavone, shown by increasing adiponectin [15][16][17] . Previous studies reported inconsistent results regarding effect of soy and soy products on adiponectin and leptin level; several studies showed no statistically significant change in the adiponectin [18][19][20][21][22][23][24][25][26] . Of interest, Llanos et al 27 reported soy protein supplement (40 g) resulted in significant adiponectin reduction.…”

Doenjang, a Korean Fermented Soy Food, Exerts Antiobesity and Antioxidative Activities in Overweight Subjects with the PPAR-γ2 C1431T Polymorphism: 12-Week, Double-Blind Randomized Clinical Trial

“…33 However, in a previous study, a high dose of 160 mg of isoflavones (20 g of soy protein) over 12 weeks did not improve inflammatory parameters in androgen-deprived men with prostate cancer. 34 Genistein inhibits the proliferation and differentiation of 3T3-L1 cells, a preadipocyte cell line, by increasing the CCAAT/enhancer-binding protein beta (C/EBP beta) activity and impacting PPAR-c protein expression. 35 Soybean fermented for longer periods improves the insulin resistance.…”

Current Status and Future Prospects of Nutraceuticals in Prostate Cancer

“…Participants were randomly assigned to receive 20 g of soy protein containing 160 mg of total isoflavones versus taste-matched placebo (20 g whole milk protein) for 12 weeks. The results demonstrate that isoflavones did not improve metabolic or inflammatory parameters in androgen-deprived men (Napora et al 2011). Another double-blind randomized clinical trial was conducted in 85 participants who received combined supplement containing isoflavones and curcumin or placebo daily.…”