High-Dose Methotrexate–Doxycycline Interaction

Abstract

The potential interaction between MTX and doxycycline may cause pharmacokinetic changes, and its clinical repercussions on the quality of life of the patient and associated costs should be considered.

British Association of Dermatologists’ guidelines for the safe and effective prescribing of methotrexate for skin disease 2016

“…Other antibiotics, including penicillins, tetracyclines and ciprofloxacin, have been shown to increase MTX levels when high‐dose MTX is used, but this does not appear to be an issue in clinical practice. Patients on long‐term antibiotics for conditions such as acne may require monitoring more frequently, but if antibiotics are given for a severe infection or an infection that is not responding to standard treatment, MTX should be stopped until the patient recovers and the antibiotic course is complete.…”

Potenciais interações medicamentosas em pacientes com artrite reumatoide

“…In the literature consulted, no potential interaction of the medications selected in this study with those used for RA management (abatacept, adalimumab, etanercept, infliximab, leflunomide, and hydroxychloroquine sulfate) has been reported. 13,27,28 Rev Bras Reumatol 2011;51(1): [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Methotrexate is the most used initial therapy in RA patients, except for those with liver disease. 26 Despite its excellent efficacy and tolerability profiles, in addition to its low cost, 29 methotrexate can interact with other medications, resulting in toxicity.…”

High-dose methotrexate in adult oncology patients: A case-control study assessing the risk association between drug interactions and methotrexate toxicity

“…10,12 Drugs with similar renal clearance as MTX have also been associated with delaying MTX clearance. 13 Evidence describing such drug interactions with acyclovir, 14 allopurinol 15 and certain antibiotics [16][17][18][19][20][21][22][23][24] has come predominantly from animal studies and case reports. Evidence describing interactions with proton pump inhibitors (PPIs) has come from more recent observational studies.…”