Potenciais interações medicamentosas em pacientes com artrite reumatoide

Abstract

Introduction: The term polypharmacy, meaning the concomitant use of multiple medications by one individual, has been widely reported in institutionalized or elderly patients. It can, however, occur in patients with chronic diseases, such as rheumatoid arthritis (RA). Objective: To quantify polypharmacy in a group of RA patients and to assess the risk of potential undesirable interactions between medications used for managing RA and those used for non-chronic diseases. Methods: A cohort study was carried out with 103 RA patients registered at the Strategy of Access to Medications from the Brazilian Health Ministry, at the School of Pharmacy of the city of Florianópolis, state of Santa Catarina. Patients were monthly followed up by use of form completion. Drug interactions were identified by use of the Drugdex System-Thomson Micromedex ®-Interactions database. Results: Polypharmacy was found in 95.1% of the patients, and 19 potential undesirable interactions were observed between the drugs used by 74 patients (mean of 3.0 ± 1.2 interactions/ patient). All potential interactions were related to methotrexate. Omeprazole was the major representative, accounting for 29.3% of the interactions, followed by diclofenac sodium (17.6%), and metamizole sodium (13.2%). Conclusion: Considering that this study confirms that polypharmacy is a common therapeutic practice in RA patients, it is worth emphasizing the need for greater surveillance regarding the adverse effects or effectiveness reduction of certain drugs due to drug interaction.

Drug interactions in the treatment of rheumatoid arthritis and psoriatic arthritis

“…Drug-related problems in RA patients like drug-choice, dosing, drug use and drug interaction problems were generally discussed by Ma et al [3]. A further study was found focusing on the quantification of polypharmacy in RA patients and investigating the interaction risk of these patients [4]. The majority of previous reviews, however, is focused on the risk of potential interactions of single drug combinations with methotrexate (MTX) [5][6][7][8], but so far there is no detailed review on the whole range of drugs used for managing inflammatory joint diseases.…”

“…This mandatory long-term polypharmacy can result in potentially harmful drug-drug interactions (DDIs). A considerable amount of literature is available on the risk of potential interactions of single drug combinations [3][4][5][6][7][8] but to our knowledge there is no detailed review on the whole range of drugs used for managing inflammatory joint diseases.…”

Drug Interactions in Elderly People Making use of oral Anticoagulants and Hospitalized in a Cardiology Hospital / Interações Medicamentosas nos Idosos em uso de Anticoagulantes Orais Internados num Hospital Cardiológico

“…In addition to this classification, the interactions can be divided as to their speed of onset, such as 1) fast, when the effects of the interaction occur within 24 hours; 2) slow, late or delayed, when they occur after 24 hours; and 3) unspecified, when there is no documentation in the literature about the onset of the effects of drug interaction. ( 20,21 For the analysis, eight drugs that were prescribed to a greater number of patients and that interacted with Warfarin were selected. These, although they were the most prescribed ones, are not necessarily those of greater severity ( Table 1).…”

Potenciais Interações Medicamentosas Em Prescrições Oriundas Do Hospital Municipal E Pronto Socorro De Barra Do Garças/Mt

“…A farmacoterapia é amplamente utilizada no tratamento de patologias, sendo responsável pela melhoria da qualidade e expectativa de vida da população (CORONA-ROJO et al, 2009). A frequente prescrição simultânea de medicamentos, no entanto, com o intuito de ampliar a eficácia da prescrição e até mesmo tratar doenças coexistentes, denominada polifarmácia, pode resultar na interação entre os fármacos desencadeando dessa forma respostas indesejadas (SECOLI, 2010;BAGATINI et al, 2011).…”