High dose sensitivity of N-(isobutoxymethyl)acrylamide polymer gel dosimeters with improved monomer solubility using acetone co-solvent

Rabaeh, Khalid A.; Al-Ajaleen, Musab S.; Abuzayed, Manar H.; Aldweri, Feras M.; Eyadeh, Molham M.

doi:10.1016/j.nimb.2019.01.029

Cited by 29 publications

(9 citation statements)

References 52 publications

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“…Acetone was also proposed and studied as a cosolvent to enhance the performance of PGDs. For example, Rabaeh et al [ 128 ] studied the solubility of N-(isobutoxymethyl) acrylamide (NIBMA) monomers in NIBMAGAT dosimeters. In this case, the authors were able to double the total concentration of comonomers (NIBMA and BIS) from 4 wt% to 8 wt% by incorporating 20 vol% of acetone and 20% of glycerol as cosolvents, which also resulted in a sixfold increase in the sensitivity value within a linear dose range of 0 to 10 Gy measured by NMR.…”

Section: Chemical and Physical Interactions Present In Gel Dosimetrymentioning

confidence: 99%

Chemical Overview of Gel Dosimetry Systems: A Comprehensive Review

Macchione

Páez

Strumia

et al. 2022

Gels

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Advances in radiotherapy technology during the last 25 years have significantly improved both dose conformation to tumors and the preservation of healthy tissues, achieving almost real-time feedback by means of high-precision treatments and theranostics. Owing to this, developing high-performance systems capable of coping with the challenging requirements of modern ionizing radiation is a key issue to overcome the limitations of traditional dosimeters. In this regard, a deep understanding of the physicochemical basis of gel dosimetry, as one of the most promising tools for the evaluation of 3D high-spatial-resolution dose distributions, represents the starting point for developing new and innovative systems. This review aims to contribute thorough descriptions of the chemical processes and interactions that condition gel dosimetry outputs, often phenomenologically addressed, and particularly formulations reported since 2017.

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Section: Chemical and Physical Interactions Present In Gel Dosimetrymentioning

confidence: 99%

Chemical Overview of Gel Dosimetry Systems: A Comprehensive Review

Macchione

Páez

Strumia

et al. 2022

Gels

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“…Various studies have analyzed the MRI response of polymer gels for possible application in radiotherapy dose mapping ([ 58 , 63 ] and references therein). In particular, polymer gels have been investigated for dosimetry in conformal therapy, IMRT, IMAT, IGRT, VMAT and tomotherapy [ 55 , 70 , 83 , 88 , 102 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 ], small photon fields [ 136 , 137 , 138 ], stereotactic radiosurgery [ 55 , 139 , 140 , 141 , 142 ], 60-cobalt source [ 143 , 144 ], brachytherapy [ 55 , 85 , 92 , 145 , ...…”

Section: Polyacrylamide Gelsmentioning

confidence: 99%

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Marrale

D’Errico

2021

Gels

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Radiation-sensitive gels are among the most recent and promising developments for radiation therapy (RT) dosimetry. RT dosimetry has the twofold goal of ensuring the quality of the treatment and the radiation protection of the patient. Benchmark dosimetry for acceptance testing and commissioning of RT systems is still based on ionization chambers. However, even the smallest chambers cannot resolve the steep dose gradients of up to 30–50% per mm generated with the most advanced techniques. While a multitude of systems based, e.g., on luminescence, silicon diodes and radiochromic materials have been developed, they do not allow the truly continuous 3D dose measurements offered by radiation-sensitive gels. The gels are tissue equivalent, so they also serve as phantoms, and their response is largely independent of radiation quality and dose rate. Some of them are infused with ferrous sulfate and rely on the radiation-induced oxidation of ferrous ions to ferric ions (Fricke-gels). Other formulations consist of monomers dispersed in a gelatinous medium (Polyacrylamide gels) and rely on radiation-induced polymerization, which creates a stable polymer structure. In both gel types, irradiation causes changes in proton relaxation rates that are proportional to locally absorbed dose and can be imaged using magnetic resonance imaging (MRI). Changes in color and/or opacification of the gels also occur upon irradiation, allowing the use of optical tomography techniques. In this work, we review both Fricke and polyacrylamide gels with emphasis on their chemical and physical properties and on their applications for radiation dosimetry.

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“…New developments in radiotherapy have been concerned with the study of equivalent gel dosimeters for tissues containing active chemical sensors to measure the absorbed radiation dose [ 1 , 2 , 3 , 4 , 5 , 6 ]. Gel dosimeters such as polymer gels have a range of properties like biological tissues, and are suitable alternatives compared with conventional dosimeters due to their ability in resolving three-dimensional (3D) dose distributions [ 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Improved Dose Response of N-(hydroxymethyl)acrylamide Gel Dosimeter with Calcium Chloride for Radiotherapy

Rabaeh

Al-Tarawneh

Eyadeh

et al. 2022

Gels

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The impact of calcium chloride (CaCl2) on the performance of N-(hydroxymethyl)acrylamide (NHMA) polymer gel dosimeter is studied in this article. The dosimeter was exposed to doses of up to 10 Gy with radiation beam-energy of 10 MV and dose-rates of 300 cGy/min. The relaxation rate (R2) parameter was utilized to explore the performance of irradiated NHMAGAT gels. The dose response in terms of R2 increased from 0.29 to 0.63 Gy−1·s−1 with increasing calcium chloride concentration from 0 to 1000 mM. The results show no substantial impact of dose-rates as well as radiation energies on NHMAGAT samples. For the steadiness of irradiated NHMAGAT dosimeters, it was found that there is no apparent variation in R2 (less than ±3%; standard deviation) up to 3 days. The overall uncertainty of the gel dosimeter with calcium chloride is 4.96% (double standard deviation, 95% confidence level).

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High dose sensitivity of N-(isobutoxymethyl)acrylamide polymer gel dosimeters with improved monomer solubility using acetone co-solvent

Cited by 29 publications

References 52 publications

Chemical Overview of Gel Dosimetry Systems: A Comprehensive Review

Chemical Overview of Gel Dosimetry Systems: A Comprehensive Review

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Improved Dose Response of N-(hydroxymethyl)acrylamide Gel Dosimeter with Calcium Chloride for Radiotherapy

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