High-dose therapy with peripheral blood progenitor cell transplantation in multiple myeloma

Abstract

Dose-escalated treatments, with particular regard to the inclusion or omission of TBI, should be prospectively investigated to find the best high-dose regimen.

Bone marrow microcirculation analysis in multiple myeloma by contrast-enhanced dynamic magnetic resonance imaging

“…VAD chemotherapy was performed as described previously. 19,21 Written informed consent was obtained from all healthy volunteers and all patients. Our study was approved by the local ethics committee.…”

“…12,15 A schematic representation of this model is given in Figure 1. An equation based on this pharmacokinetic model describes the mathematical relation between the signal change (S CM (t)/S 0 ; S CM (t): signal at the time point t after start of the contrast medium infusion and S 0 : signal before start of the contrast medium infusion) and the kinetic parameters amplitude A, exchange rate constant k 21 and k 12 (Fig. 1).…”

“…11 Contrast-enhanced dynamic MRI (dMRI) as used in our study is a computer assisted kinetic analysis of the accumulation and distribution of contrast medium (Gadolinium-DTPA) in vivo in the area of interest after a constant pump controlled bolus injection. [12][13][14][15][16] Data analysis is based on an open 2-compartment model, and information of pharmacokinetic analysis is contained in 2 parameters: the amplitude A and the tissue exchange rate constant k 21 . 12 In cervical carcinoma and mammary carcinoma, a correlation between signal amplitude A and exchange rate constant k 21 and blood vessel density has been established.…”

“…[12][13][14][15][16] Data analysis is based on an open 2-compartment model, and information of pharmacokinetic analysis is contained in 2 parameters: the amplitude A and the tissue exchange rate constant k 21 . 12 In cervical carcinoma and mammary carcinoma, a correlation between signal amplitude A and exchange rate constant k 21 and blood vessel density has been established. 15,16 The application of this method in various diseases of the bone marrow was recently reported.…”

“…17,18 The aim of our study was to perform a microcirculation analysis of bone and bone marrow of lumbar spine and right spina iliaca posterior superior in patients with MM using dMRI. Quantitative parameters A and k 21 in MM were compared with normal controls. It was investigated whether these microcirculation parameters correlate with severe osteolytic bone involvement or other clinically relevant parameters.…”