High Dose Vitamin D Supplementation in the Elderly is Both Safe and Efficacious

Ramamurthy, Rekha; Przybelski, Robert J.; Gemar, Dessa; Krueger, Diane; Binkley, Neil

doi:10.1016/j.jocd.2009.03.093

Cited by 2 publications

(2 citation statements)

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“…108 An additional clinical report of “high-dose” vitamin D 2 (50,000 IU once weekly for up to three years) achieved a 25(OH)D level above 30 ng/ml in 23/24 patients with the highest reported value being 100 ng/ml. 112 …”

Section: Approaches To Vitamin D Repletion/supplementationmentioning

confidence: 99%

Low Vitamin D Status: Definition, Prevalence, Consequences, and Correction

Binkley

Ramamurthy

Krueger

2010

Endocrinology and Metabolism Clinics of North America

Self Cite

176

112

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Vitamin D is obtained from cutaneous production when 7-dehydrocholesterol is converted to vitamin D3 (cholecalciferol) by ultraviolet B radiation or by oral intake of vitamin D2 (ergocalciferol) and D3. An individual's vitamin D status is best evaluated by measuring the circulating 25-hydroxyvitamin D [25(OH)D] concentration. Though controversy surrounds the definition of low vitamin D status, there is increasing agreement that the optimal circulating 25(OH)D level should be ~30-32 ng/ml or above. Using this definition, it has been is estimated that approximately three quarters of all adults in the United States are low. Classically, low vitamin D status has skeletal consequences such as osteomalacia/rickets. More recently, associations between low vitamin D status and increased risk for various non-skeletal morbidities have been recognized; whether all of these associations are causally related to low vitamin D status remains to be determined. To achieve optimal vitamin D status, daily intakes of at least 1000 IU or more of vitamin D are required. The risk of toxicity with “high” amounts of vitamin D intake is low. Substantial between-individual variability exists in response to the same administered vitamin D dose. When to monitor 25(OH)D levels has received little attention. Supplementation with vitamin D3 may be preferable to vitamin D2.

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Section: Approaches To Vitamin D Repletion/supplementationmentioning

confidence: 99%

Low Vitamin D Status: Definition, Prevalence, Consequences, and Correction

Binkley

Ramamurthy

Krueger

2010

Endocrinology and Metabolism Clinics of North America

Self Cite

176

112

View full text Add to dashboard Cite

show abstract

“…108 An additional clinical report of "high-dose" vitamin D 2 (50,000 IU once weekly for up to three years) achieved a 25(OH)D level above 30 ng/ml in 23/24 patients with the highest reported value being 100 ng/ml. 112 Maintenance of vitamin D status with daily doses from 1,000-4,000 IU have been studied. 96,113,114 As noted above, between individual variability exists.…”

Section: Approaches To Vitamin D Repletion/supplementationmentioning

confidence: 99%