1986
DOI: 10.1111/j.1600-0722.1986.tb01793.x
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High doses of fluoride do not affect cyclic AMP levels in human and rat plasma or urine

Abstract: – The effect of fluoride ingestion on plasma and urinary cyclic AMP levels was studied in healthy volunteers, children undergoing prophylactic fluoride treatment and in rats. In the first series of experiments fluoride ingestion led to a 20‐fold increase in plasma fluoride concentration, which was unrelated to changes in plasma cyclic AMP. The only significant effect on plasma cyclic AMP occurred prior to fluoride, an effect attributed to stress. In the second series performed in children increases in urinary… Show more

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Cited by 2 publications
(2 citation statements)
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“…The concentration of fluoride ions in plasma is directly related to the fluoride content of the drinking water. This close relationship has been documented earlier by several authors [3,4,9,10] Cyclic AMP is a second messenger, used for intracellular signal transduction, such as transferring the effects of hormones like glucagon and adrenaline, which cannot pass through the cell membrane. It is involved in the activation of protein kinases and regulates the effects of adrenaline and glucagon.…”
Section: Discussionmentioning
confidence: 65%
See 1 more Smart Citation
“…The concentration of fluoride ions in plasma is directly related to the fluoride content of the drinking water. This close relationship has been documented earlier by several authors [3,4,9,10] Cyclic AMP is a second messenger, used for intracellular signal transduction, such as transferring the effects of hormones like glucagon and adrenaline, which cannot pass through the cell membrane. It is involved in the activation of protein kinases and regulates the effects of adrenaline and glucagon.…”
Section: Discussionmentioning
confidence: 65%
“…Liver being a major metabolic organ, plays an important role in regulation of biochemical and trace element metabolism and ingestion of large amount of fluoride can damage the hepatic tissue. Fluoride has been known to inhibit or activate many enzymes such as transaminases, phosphatases [2], and cyclic adenosine monophosphate (AMP) [3]. Transaminases are a common mean of detecting liver damage.…”
Section: Introductionmentioning
confidence: 99%