High-dynamic-range blood flow rate measurement in a large-diameter vessel

Yuan, Yuan; Bi, Yong; Gao, Xiao Cao; Sun, Mingzhu; Gao, Wei

doi:10.1364/ao.432846

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…Because the normalized spatial autocorrelation function g2(Δx) of the speckle image is the point spread function of the optical system, the full width at half maximum (FWHM) of g2(Δx) is taken as the speckle size, also defined as the spatial resolution 27 – 31 …”

Section: Methodsmentioning

confidence: 99%

“…Because the normalized spatial autocorrelation function g 2 ðΔxÞ of the speckle image is the point spread function of the optical system, the full width at half maximum (FWHM) of g 2 ðΔxÞ is taken as the speckle size, also defined as the spatial resolution. [27][28][29][30][31] Experimentally, the normalized spatial autocorrelation function g 2 ðΔxÞ is measured using…”

Section: Spatial Resolutionmentioning

confidence: 99%

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Wide dynamic range measurement of blood flow in vivo using laser speckle contrast imaging

Liu,

Yuan,

Han

et al. 2024

J. Biomed. Opt.

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Laser speckle contrast imaging (LSCI) is a real-time wide-field technique that is applied to visualize blood flow in biomedical applications. However, there is currently a lack of relevant research to demonstrate that it can measure velocities over a wide dynamic range (WDR), which is critical for monitoring much higher and more pulsatile blood flow in larger size myocardial vessels, such as the coronary artery bypass graft, and visualizing the spatio-temporal evolution of myocardial blood flow perfusion in cardiac surgery.Aim: We aim to demonstrate that the LSCI technique enables measuring velocities over a WDR from phantom experiments to animal experiments. In addition, LSCI is preliminarily applied to imaging myocardial blood flow distribution in vivo on rabbits.Approach: Phantom and animal experiments are performed to verify that the LSCI method has the ability to measure blood velocities over a wide range. Our method is also validated by transit time flow measurement, which is the gold standard for blood flow measurement in cardiac surgery.Results: Our method is demonstrated to measure the blood flow over a wide range from 0.2 to 635 mm∕s. To validate the phantom results, the varying blood flow rate from 0 to 320 mm∕s is detected in the rat carotid artery. Additionally, our technique also obtains blood flow maps of different myocardial vessels, such as superficial large/small veins, veins surrounded by fat, and myocardial deeper arteriole.Conclusions: Our study has the potential to visualize the spatio-temporal evolution of myocardial perfusion in coronary artery bypass grafting, which would be of great benefit for future research in the life sciences and clinical medicine.

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Section: Methodsmentioning

confidence: 99%

Section: Spatial Resolutionmentioning

confidence: 99%

Wide dynamic range measurement of blood flow in vivo using laser speckle contrast imaging

Liu,

Yuan,

Han

et al. 2024

J. Biomed. Opt.

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“…Second, it can be calculated as a fitting parameter with the dynamic scattering light imaging (DSLI) technique [10]. Here, the parameter β of our setup was determined to be 0.56 using the DSLI method in our previous work [12].…”

Section: High Dynamic Range and Sensitivity Of The Velocity Measurementsmentioning

confidence: 99%

“…For the blood flow quantitative measurement, laser speckle blood flow imaging (LSBFI) as a minimally invasive full-field imaging technique has attracted extensive attention. A number of methods have been used to measure the blood flow including laser speckle contrast imaging (LSCI) [4][5][6][7], multi-exposure speckle imaging (MESI) [8,9], dynamic light scattering imaging (DLSI) [10], time varied illumination laser speckle contrast imaging (TVI-LSCI) [11], and dynamic light scattering laser speckle contrast imaging (DLS-LSCI) [12]. These methods were performed in relatively small vessels, such as the cerebrum, the retina, and the skin.…”

Section: Introductionmentioning

confidence: 99%

Pulsatile Flow Measurement by a Speckle Triangle Assessment

Yuan

Gao

et al. 2021

Front. Phys.

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The blood flow in the coronary artery (CA) is pulsatile and much higher than that measured in the brain, retina, and skin before. Its quantitative measurement is medically significant in the coronary artery bypass grafting (CABG). Here, to the best of our knowledge, we first detect the pulsatile flow using the laser speckle contrast imaging technique. Since the factors influencing the flow rate in the CA are complex, we developed a comprehensive model, a speckle triangle assessment (STA), to assess the characteristics of the flow: the speckle flow index (SFI), mean flow index (MFI), and pulsatility index (PI). The phantom experiment was performed and found that our customized setup possessed high dynamic range of the velocity measurement with good sensitivity. It also indicated that the pulsatile flow estimated by the speckle triangle assessment is promising to obtain a more accurate assessment of a coronary artery’s patency in the CABG.

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“…In DCS and LSCI, some high-speed cameras have been used to record the raw laser speckle signal and measure g 2 (τ ) in a 2D field of view (FOV) 27,28 . In addition, SPAD arrays are utilized by speckle contrast optical spectroscopy to create synthetic multiple-exposure speckle contrast data [29][30][31] .…”

Section: Introductionmentioning

confidence: 99%

Wide-field Intensity Fluctuation Imaging

Fang

Tomar

Dunn

2023

Preprint

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The temporal intensity fluctuations contain important information about the light source and light-medium interaction and are typically characterized by the intensity autocorrelation function, g_2(τ). The measurement of g_2(τ) is a central topic in many optical sensing applications, ranging from stellar intensity interferometer in astrophysics, to fluorescence correlation spectroscopy in biomedical sciences and blood flow measurement with dynamic light scattering. Currently, g_2(τ) at a single point is readily accessible through high-frequency sampling of the intensity signal. However, two-dimensional wide-field measurement of g_2(τ) is still limited by camera frame rates. We propose and demonstrate a 2-pulse within-exposure modulation approach to break through the camera frame rate limit and obtain the quasi g_2(τ) map in wide field with cameras of only ordinary frame rates.

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High-dynamic-range blood flow rate measurement in a large-diameter vessel

Cited by 8 publications

References 18 publications

Wide dynamic range measurement of blood flow in vivo using laser speckle contrast imaging

Wide dynamic range measurement of blood flow in vivo using laser speckle contrast imaging

Pulsatile Flow Measurement by a Speckle Triangle Assessment

Wide-field Intensity Fluctuation Imaging

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