High efficiency canthaxanthin production by a novel mutant isolated from Dietzia natronolimnaea HS-1 using central composite design analysis

Gharibzahedi, Seyed Mohammad Taghi; Razavi, Seyed Hadi; Mousavi, Mohammad; Moayedi, V.

doi:10.1016/j.indcrop.2012.03.030

Cited by 52 publications

(47 citation statements)

References 28 publications

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“…The procedure described by Gharibzahedi et al (2012a) was used for the determination of the biomass dry weight (BDW). Briefly, a concentrated cell suspension was diluted with a suitable amount of the synthetic mineral medium to give an optical density ranging from 0.1 to 1.0 when measured at 600 nm.…”

Section: Methodsmentioning

confidence: 99%

“…It probably might be due to the long-time exposure of the dissolved carotenoids to oxygen, light, and microorganisms in the environment which leads to the chance increase of oxidation or degradation of the dissolved carotenoids. In addition, the depletion of carbon in YM medium at these times might have caused the decreased production of carotenoids (Gharibzahedi et al 2012a). The results showed that the increase of the yeast extract concentration to 8.3 g/l due to the accurate pH-adjustment increased the TCT and CTX biosyntheses in a batch bioreactor.…”

Section: Model Interpretationmentioning

confidence: 98%

“…Natural carotenoid pigments have been commercially used as food colorants, nutraceuticals, cosmetics and animal feed supplements (Gharibzahedi et al 2012a). It has been reported that carotenoid pigments have potent antioxidant activity and have a key role in delaying or preventing degenerative diseases in humans and animals (Gharibzahedi et al a,b).…”

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confidence: 99%

“…Several researchers studied the CTX production by d. natronolimnaea HS-1 from the different carbon substrates (Khodaiyan et al 2007(Khodaiyan et al , 2008Nasri Nasrabadi & Razavi 2010a,b;Gharibzahedi et al 2012a). Khodaiyan et al (2007) showed that glucose and fructose sugars can lead to increases in the cell biomass and carotenoids, especially in CTX synthesis in a batch bioreactor.…”

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confidence: 99%

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Enzymatically hydrolysed molasses and sodium citrate as new potentials for the improvement of canthaxanthin batch synthesis by Dietzia natronolimnaea HS-1: A statistical media optimisation

Gharib¹,

Razavi²,

Mousavi³

2014

Czech J. Food Sci.

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Gharibzahedi S.M.T., Razavi S.H., Mousavi M. (2014): Enzymatically hydrolysed molasses and sodium citrate as new potentials for the improvement of canthaxanthin batch synthesis by Dietzia natronolimnaea HS-1: A statistical media optimisation. Czech J. Food Sci., 32: 326-336.Response surface methodology-central composite rotatable design (RSM-CCRD) was applied to explore the optimum media formulation for maximising canthaxanthin (CTX) biosynthesis by dietzia natronolimnaea HS-1. The effects of three variables of enzymatically hydrolysed molasses (EHM) (16.6-33.4 g/l), sodium (Na)-citrate (21.64-28.36mM), and yeast extract (6.32-9.68 g/l) concentrations on the production of CTX, total carotenoid (TCT), and biomass dry weight (BDW) were appraised. The results showed that the quadratic effects of EHM, yeast extract, and Na-citrate contents in terms of second-order polynomial regression equations (r 2 = 0.968-0.986), respectively, had the most significant effects on the produced TCT and CTX. The predicted maximum accumulation of BDW (8.88 g/l), TCT (7.24 mg/l), and CTX (6.40 mg/l) under the optimum concentrations of the media variables (26.16 g/l EHM, 8.29 g/l yeast extract, and 25.86mM Na-citrate) was very close to the experimental values determined in batch experiments. The high BDW content suggested EHM and Na-citrate as very promising feedstocks for CTX bioproduction by the bacterium studied.

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Section: Methodsmentioning

confidence: 99%

Section: Model Interpretationmentioning

confidence: 98%

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confidence: 99%

mentioning

confidence: 99%

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Enzymatically hydrolysed molasses and sodium citrate as new potentials for the improvement of canthaxanthin batch synthesis by Dietzia natronolimnaea HS-1: A statistical media optimisation

Gharib¹,

Razavi²,

Mousavi³

2014

Czech J. Food Sci.

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“…If they are not available, coupling the methods of Diode Array Detectors (DAD), Photodiode Array (PDA) or UV-VIS (Fong et al, 2001) with chromatography LC-MS/MS contributes with the results. A recent study analyzed the pigment canthaxanthin using an UV-HPLC method, with separation in a Lichrospher 100 RP-18 silica column, the isocratic mobile phase used was acetonitrile and methanol (80:20, v/v) at a flow rate of 2 mL/min (Gharibzahedi et al, 2012). Also, the carotenoids produced by Haloferax alexandrines TMT strain were analyzed by HPLC, and the carotenoids β-carotene, 3-hydroxyechinenone, γ-carotene, cisastaxanthin, lycopene, anhydrobacterioruberin, bacterioruberin isomer, bacterioruberin and canthaxanthin were identified .…”

Section: Extraction Purification and Identification Of Carotenoidsmentioning

confidence: 99%

Microbial production of carotenoids A review

Cardoso¹,

Kanno²,

Karp³

2017

Afr. J. Biotechnol.

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Carotenoids are natural pigments that can be synthesized by various microorganisms, including bacteria, yeasts, filamentous fungi and microalgae. These pigments comprise around 700 different structures with peculiar colors and biological properties that are beneficial to health. Advantages of biotechnological production of carotenoids include the ability of microorganisms to use low cost substrates, the optimized control of cultivation, minimized production time and the natural origin of the synthesized pigments. Techniques for separation and purification of carotenoids are well established at laboratory scale, however the development of processes that can be economically scaled-up is essential for industrial production.

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Microbial canthaxanthin: Perspectives on biochemistry and biotechnological production

Gharibzahedi

Razavi

Mousavi

2013

Engineering in Life Sciences

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Canthaxanthin (CX) as a high‐value carotenoid is widely used in medical, pharmaceutical, cosmetic, chemical, and food industries. In this review, recent developments in the biotechnological production of CX associated with comprehensive insights on CX biosynthesis pathways to improve CX production are critically scrutinized. This article explains the role of carotenogenic genes in the precursor's synthesis of functional CX ingredients. It also explores the possibilities for productivity enhancement of microbial CX in upstream and downstream processes. Moreover, several promising directions for future studies are introduced.

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High efficiency canthaxanthin production by a novel mutant isolated from Dietzia natronolimnaea HS-1 using central composite design analysis

Cited by 52 publications

References 28 publications

Enzymatically hydrolysed molasses and sodium citrate as new potentials for the improvement of canthaxanthin batch synthesis by Dietzia natronolimnaea HS-1: A statistical media optimisation

Enzymatically hydrolysed molasses and sodium citrate as new potentials for the improvement of canthaxanthin batch synthesis by Dietzia natronolimnaea HS-1: A statistical media optimisation

Microbial production of carotenoids A review

Microbial canthaxanthin: Perspectives on biochemistry and biotechnological production

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