High-efficiency immunomagnetic isolation of solid tissue-originated integrin-expressing adult stem cells

Palmon, Aaron; David, Ran; Neumann, Yoav; Stiubea-Cohen, Raluca; Krief, Guy; Aframian, Doron J.

doi:10.1016/j.ymeth.2011.10.002

Cited by 16 publications

(15 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evidence substantiating that functional recovery can be achieved through the preferential administration of transplanted cells via retrograde ductal injection needs to be obtained. Moreover, while several candidate salivary gland stem/progenitor cells have been suggested for human use (13,42,108,127,136,157), safety issues need to be addressed experimentally before their clinical application (79). …”

Section: Stem Cell Therapy To Ameliorate Radiation-induced Xerostomiamentioning

confidence: 99%

Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects

Benderitter

Caviggioli

Chapel

et al. 2014

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

Significance: Targeted irradiation is an effective cancer therapy but damage inflicted to normal tissues surrounding the tumor may cause severe complications. While certain pharmacologic strategies can temper the adverse effects of irradiation, stem cell therapies provide unique opportunities for restoring functionality to the irradiated tissue bed. Recent Advances: Preclinical studies presented in this review provide encouraging proof of concept regarding the therapeutic potential of stem cells for treating the adverse side effects associated with radiotherapy in different organs. Early-stage clinical data for radiation-induced lung, bone, and skin complications are promising and highlight the importance of selecting the appropriate stem cell type to stimulate tissue regeneration. Critical Issues: While therapeutic efficacy has been demonstrated in a variety of animal models and human trials, a range of additional concerns regarding stem cell transplantation for ameliorating radiationinduced normal tissue sequelae remain. Safety issues regarding teratoma formation, disease progression, and genomic stability along with technical issues impacting disease targeting, immunorejection, and clinical scale-up are factors bearing on the eventual translation of stem cell therapies into routine clinical practice. Future Directions: Follow-up studies will need to identify the best possible stem cell types for the treatment of early and late radiation-induced normal tissue injury. Additional work should seek to optimize cellular dosing regimes, identify the best routes of administration, elucidate optimal transplantation windows for introducing cells into more receptive host tissues, and improve immune tolerance for longer-term engrafted cell survival into the irradiated microenvironment. Antioxid. Redox Signal. 21, 338-355.

show abstract

Section: Stem Cell Therapy To Ameliorate Radiation-induced Xerostomiamentioning

confidence: 99%

Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects

Benderitter

Caviggioli

Chapel

et al. 2014

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

show abstract

“…Although consensus is that some form of the salivary gland cellular therapy is feasible to increase the quality of life of head and neck cancer patients particularly post radiotherapy, considerable hurdles facing the development of a cellular therapy based upon a prolonged in vitro culture that can affect the expression of cell surface markers, which define this hierarchy [122].…”

Section: Radiotherapy and Salivary Glandsmentioning

confidence: 99%

Adult Gland Derived Stem Cells (Gdscs); Potentials, Hurdles and Expectations

M¹

2014

J Stem Cell Res Ther

View full text Add to dashboard Cite

“…The concept of "stem cells" in adult oral tissues can be traced back to the identification of a subset of cycling populations that possessed self-renewal characteristics with extensive proliferative capacity in epithelial tissues: oral epithelium, junctional epithelium, salivary glands, ectomesenchymally derived tissue lamina propria of the oral mucosa, pulp, and the attachment apparatus of the oral cavity [6,[16][17][18][19]. In the late 1970s and early 1980s, Melcher's group at the University of Toronto focused on the biology of the periodontium with specific emphasis on the periodontal ligament.…”

Section: Periodontal Ligamentmentioning

confidence: 99%

Periodontal Stem Cells: a Historical Background and Current Perspectives

Pitaru¹,

Narayanan

Etikala

et al. 2013

Curr Oral Health Rep

View full text Add to dashboard Cite

In this review we discuss the historical perspective of stem cell populations from oral tissues in light of our current understanding of stem cell biology. Stem cells and their niches have been identified in the periodontium starting from the late 1970s. Applying new criteria for the identification and characterization reveals that oral tissues comprise a multipotent primitive neural crest-like stem cell population capable of differentiating into neural crest derived cell lineages of the cranial-facial zone. This population supplies cells to a more restricted stem cell type with tissue specific epigenetic memory that differentiates into cell lineages characteristic of their tissue origin. We believe that the microenvironment plays an essential role in maintaining stem cell populations and directing their migration and differentiation, and that this factor needs to be considered for utilization of stem cell-based therapy for periodontal regeneration and regenerative dental medicine.

show abstract

High-efficiency immunomagnetic isolation of solid tissue-originated integrin-expressing adult stem cells

Cited by 16 publications

References 6 publications

Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects

Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects

Adult Gland Derived Stem Cells (Gdscs); Potentials, Hurdles and Expectations

Periodontal Stem Cells: a Historical Background and Current Perspectives

Contact Info

Product

Resources

About