Studies on the adsorption and transport of water molecules with oxidized two‐dimensional (2 D) carbon materials have attracted increasing interest owing to their wide range of applications, such as sensing, energy conversion, and membrane separation. In this contribution, the interaction between water molecules and oxidized 2 D carbon materials (i.e., graphene oxide and graphdiyne oxide) is discussed, the influence of water adsorption and transport on the physicochemical properties of 2 D carbon materials is presented, and the recent progress on oxidized 2 D carbon material‐based proton conduction, electricity generation, water transport, and humidity sensing is highlighted. The opportunities and challenges in these research fields are discussed, especially the structural stability and chemical modification of 2 D carbon materials.