High eradication rates of <i>Helicobacter pylori</i> with a new sequential treatment

Zullo, Angelo; Vaira, Dino; Vakil, Nimish; Hassan, Cesare; Gatta, Luigi; Ricci, Chiara; Francesco, Vincenzo De; Menegatti, Marcello; Tampieri, Andrea; Perna, Francesco; Rinaldi, Vittorio; Perri, Francesco; Papadia, Cinzia; Fornari, Fabio; Pilati, S.; Mete, L. Sanchez; Merla, Antonio; Potì, R; Marinone, G; Savioli, A.; Campo, Salvatore; Faleo, D.; Ierardi, Enzo; Miglioli, M.; Morini, Sergio

doi:10.1046/j.1365-2036.2003.01461.x

Cited by 211 publications

(172 citation statements)

References 40 publications

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“…Previous studies have also shown that sequential therapy achieves better eradication rates than 7-day triple therapy. In a study by Zullo et al, [12] eradication rates for the sequential therapy were 92% by intent to treat and 95% per protocol. A recent study from Turkey [15] found that the eradication rate was higher for sequential therapy (93.7%) than standard therapy (46.4%).…”

Section: Discussionmentioning

confidence: 97%

“…This regimen, compared with the conventional triple therapy, improved eradication rates by 18% and 22%, respectively, was well tolerated, safe and had good compliance in both adults and children. [12,13] Local data on eradication rates are not available but anecdotal evidence suggests that there are increasing failure rates to the standard triple therapy regimens.…”

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confidence: 99%

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Effectiveness of sequential v. standard triple therapy for treatment of Helicobacter pylori infection in children in Nairobi, Kenya

et al. 2013

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Background. Once the diagnosis of Helicobacter pylori is confirmed, treatment requires at least two antibiotics and an acid inhibitor for a minimum of seven days. Unfortunately, treatment failures are being frequently reported. Treatment regimens that include sequential administration of antibiotics with acid inhibitors have been developed to try and increase the rate of eradication. Objective. To determine the effectiveness of a novel 10-day sequential therapy compared with the standard 10-day triple therapy for treatment of H. pylori infection in children. Methods. A double-blinded, randomised, controlled trial was conducted. Children under the age of 16 years with recurrent abdominal pain associated with dyspepsia and diagnosed with H. pylori by histology were randomly allocated either to a 10-day sequential treatment regimen or to a 10-day conventional triple therapy. Analysis of the outcome of this study was based on clinical improvement and confirmed H. pylori eradication based on stool H. pylori antigen detection and/or repeat endoscopy. Results. Of the 71 patients included in the analysis, 45 (63.4%) were given the 10-day conventional treatment while 26 (36.6%) received the 10-day sequential treatment. There was no difference in clinical improvement after treatment in the two therapies. However, there was a significant difference in the eradication of H. pylori between the conventional v. sequential regimens (48.8% v. 84.6%, respectively; p=0.02, odds ratio 0.19). Conclusion. The sequential treatment had a significantly higher H. pylori eradication rate than the conventional treatment.

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Section: Discussionmentioning

confidence: 97%

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confidence: 99%

Effectiveness of sequential v. standard triple therapy for treatment of Helicobacter pylori infection in children in Nairobi, Kenya

et al. 2013

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“…The sequential scheme, developed by Italian researchers, consists of administering a standard dose of proton pump inhibitor with 1.0 g of amoxicillin, twice daily for the 1st 5 days, followed by administering of the standard dose of proton pump inhibitor, 500 mg of clarithromycin and 500 mg of tinidazole administered twice daily for a further 5-day period. Although most studies are still restricted to a single country, the initial results show eradication rates around 90% (58,104,199,216) , with some Asian studies showing less significant results (23) . There is a lack of confirmatory studies as to the effectiveness of this scheme among us.…”

Section: Statement 29mentioning

confidence: 99%

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Coelho

Maguinilk

Zaterka³

et al. 2013

Arq. Gastroenterol.

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Significant progress has been obtained since the Second Brazilian Consensus Conference on Helicobacter pylori Infection held in 2004, in São Paulo, SP, Brazil, and justify a third meeting to establish updated guidelines on the current management of H. pylori infection. The Third Brazilian Consensus Conference on H pylori Infection was organized by the Brazilian Nucleus for the Study of Helicobacter, a Department of the Brazilian Federation of Gastroenterology and took place on April 12-15, 2011, in Bento Gonçalves, RS, Brazil. Thirty-one delegates coming from the five Brazilian regions and one international guest, including gastroenterologists, pathologists, epidemiologists, and pediatricians undertook the meeting. The participants were allocated in one of the five main topics of the meeting: H pylori, functional dyspepsia and diagnosis; H pylori and gastric cancer; H pylori and other associated disorders; H pylori treatment and retreatment; and, epidemiology of H pylori infection in Brazil. The results of each subgroup were submitted to a final consensus voting to all participants. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. Seventy per cent and more votes were considered as acceptance for the final statement. This article presents the main recommendations and conclusions to guide Brazilian doctors involved in the management of H pylori infection.

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“…Other studies in this regard also have shown similar results; The study of Odaka et al showed that eradication of H. pylori was seen in 155 cases out of 163 (92%, CI 95%: 88% -96%) using Amoxicillin, Metronidazole and Roxithromycine (18). In another study by A. Zullo et al a new approach in H. pylori-infected patients, receiving 10 days sequential therapy [Rabeprazole (40 mg daily) plus Amoxicillin (1 g twice a day) for the first 5 days, followed by Rabeprazole (20 mg), Clarithromycin (500 mg) and Tinidazole (500 mg) twicedaily for the remaining 5 days] eradication of H. pylori was higher than the control group (19 (22). Other studies have revealed that the prevalence of H. pylori infection in developing countries is higher in young age patients.…”

Section: Discussionmentioning

confidence: 98%

Efficiency of Helicobacter pylori Infection Treatment Protocol: Clarithromycin, Amoxicillin and Omeprazole

Saleh

Zarrintan

Zade

et al. 2012

Arch Clin Infect Dis

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Implication for health policy/practice/research/medical education: Clarithromycin, Amoxicillin and Omeprazole for treatment of H. pylori infection can be useful which is concluded from lower levels of IgG and CagA in blood and H. pylori antigen in stool after treatment compared to the amount of these factors before therapy. Copyright © 2013, Infectious Diseases and Tropical Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. BackgroundHelicobacter pylori (H. pylori) is a gram negative, spiral and flagella bacteria, colonized in the mucosa of stomach which has an important etiologic role in gastric diseases especially gastric ulcers (1). H. pylori is one of the most common pathogens affecting humans, which approximately infects 50% of the world population that remains as a significant cause of morbidity and mortality (2). Several studies have shown the relationship among this organism and some other gastric diseases such as ischemic heart disease, idiopathic thrombocytopenic purpura, and iron deficiency anemia, etc. (3). Recent evidences demonstrate that H. pylori has an important role in some of the skin diseases progression, e.g. Reynaud's disease, Rosacea, prurigo nodular is atopic dermatitis and chronic urticaria (4, 5). H. pylori is a very common infection which occurs at young ages in developing countries. One of the significantly independent risk factors for infection is low socioeconomic status (6). Many epiddemiologic studies of H. pylori have confirmed that the infection to this bacterium is observed among children in developing countries, which may be due to bad household hygiene and sanitation (7-9). Furthermore, these studies about H. pylori transmission showed that the majority of infections tend to occur within families through close person-to-person contact (10). H. pylori infection seems to be transmitted most readily among siblings who are in Background: Helicobacter pylori (H. pylori) is one of the most common pathogen affecting humans, which is approximately infecting 50% of the world population and remains as a significant cause of morbidity and mortality. Since the discovery of Helicobacter pylori in early 1980, many treatment regimens have been developed to effectively treat this infection. Despite the extensive research over the last 25 years the treatment of Helicobacter pylori remains a challenging clinical problem due to its antimicrobial resistance. Objectives: This study aimed to evaluate Clarithromycin, Amoxicillin and Omeprazole efficiency as a treatment for H. pylori. Patients and Methods:The patients with clinical features of H. pylori infection and positive serological and clinical test results were entered to the study. Whole of the patients enrolled in the study were given a full two weeks of effective treatment protocol of H. pylori consisted of Clarithromycin (20 mg PO bid), A...

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High eradication rates of Helicobacter pylori with a new sequential treatment

Cited by 211 publications

References 40 publications

Effectiveness of sequential v. standard triple therapy for treatment of Helicobacter pylori infection in children in Nairobi, Kenya

Effectiveness of sequential v. standard triple therapy for treatment of Helicobacter pylori infection in children in Nairobi, Kenya

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Efficiency of Helicobacter pylori Infection Treatment Protocol: Clarithromycin, Amoxicillin and Omeprazole

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