High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer

Abstract

Abstract. Members of the ADAMTS family contain propeptide, metalloproteinase and disintegrin domains and serve key roles for cancer cell proliferation, progression and metastasis. Although overexpression of ADAMTS5 has been reported in glioblastoma, and head and neck cancer, little has been demonstrated in colorectal cancer types. The present study aimed to clarify the significance of ADAMTS5 for clinicopathological factors and prognosis in colorectal cancer. The mRNA expression of ADAMTS5 was measured in 143 colorectal cancer specimens. ADAMTS5 expression was increased as the pathological stage increased. The expression of ADAMTS5 in stage III-IV colorectal cancer was significantly greater compared with that of stage 0-II colorectal cancer (P=0.0003). The median expression of ADAMTS5 was used to divide the ADAMTS5 higher expressing group and the ADAMTS5 lower expressing group to assess the correlation of ADAMTS5 expression with clinicopathological factors and prognosis. The proportions of lymphatic invasion and lymph node metastasis were significantly greater in the ADAMTS5 higher expressing group (P=0.0214 and P=0.0289 respectively). Overall survival and disease-free survival were assessed by the Kaplan-Meier curve with calculation of significance by the log-rank test; however, no significant difference was observed between the ADAMTS5 higher expressing group and the ADAMTS5 lower expressing group (P=0.7490 and P=0.9455, respectively). The present study confirmed high expression of ADAMTS5 as a potent marker for lymphatic invasion and lymphnode metastasis in colorectal cancer. To clarify the function of ADAMTS5 in colorectal cancer, further molecular investigations are required.

Prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer from multiple centers in China

“…When lymphatic vessels are distributed in the submucosa, lymph node metastasis is likely to occur when the tumor invades the submucosa. When the tumor invades the deep intestinal wall, the lymph node metastasis rate will increase significantly[ 28 , 29 ]. In our study, the lymph node metastasis rate of this group of patients with T1-stage CRC was 8.41%, which is mostly consistent with previous reports[ 7 , 8 ].…”

Differential DNA methylation analysis of SUMF2, ADAMTS5, and PXDN provides novel insights into colorectal cancer prognosis prediction in Taiwan

“…The expression level of ADAMTS5 was increased in late CRC stages, and ADAMTS5 may have served as the fundamental component of tumor invasion through degrading ECM so as to promote tumor progression to more advanced stages of CRC[ 35 ]. The ratios of lymphatic invasion and lymph node metastasis were significantly higher in patients with CRC and high ADAMTS5 expression, but such expression did not affect OS and DFS[ 36 ]. However, Li et al [ 37 ] suggested that ADAMTS5 overexpression inhibited the invasion and migration of CRC, and ADAMTS5 was more hypermethylated in tumor tissue compared with normal tissue, corresponding to poor OS and DFS .…”

Survival prediction in patients with colon adenocarcinoma via multiomics data integration using a deep learning algorithm

“…ADAMTS5 is overexpressed in CRC, promoting CRC metastasis and cancer cell invasion [ 37 ]. High expression of ADAMTS5 is a potent biomarker for lymphatic invasion and lymph node metastasis in CRC [ 38 ]. These results indicate that these molecules may be used as promising biomarkers and therapeutic targets for COAD.…”