High expression of <i>N</i>‐acetylglucosaminyltransferase V in favorable neuroblastomas: Involvement of its effect on apoptosis

Inamori, Kei-ichiro; Gu, Jianguo; Ohira, Miki; Kawasaki, Atsushi; Nakamura, Yohko; Nakagawa, Takatoshi; Kondo, Akihiro; Miyoshi, Eiji; Nakagawara, Akira; Taniguchi, Naoyuki

doi:10.1016/j.febslet.2005.12.089

Cited by 44 publications

(31 citation statements)

References 24 publications

(42 reference statements)

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“…In the current study, we found that MGAT5 was expressed in the Numerous studies have been confirmed a upregulation of MAGT5 in human tumors, such as breast cancer [20], colon carcinoma [22] and that upregulation of MGAT5 suggests favorable prognosis for bladder carcinoma [32], non-small cell lung cancer [33] and neuroblastoma [34]. primary trophoblast cells, is that it both reflects the complicated relationship between different types of cells and maintains the integrity of the tissue structure [36].…”

Section: Discussionsupporting

confidence: 54%

N-acetylglucosaminyltransferase V inhibits the invasion of trophoblast cells by attenuating MMP2/9 activity in early human pregnancy

et al. 2015

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Section: Discussionsupporting

confidence: 54%

N-acetylglucosaminyltransferase V inhibits the invasion of trophoblast cells by attenuating MMP2/9 activity in early human pregnancy

et al. 2015

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“…Previous reports on the relationship between GnT-V expression and the prognosis in various cancers were controversial (8,11,12,17,18), but our data strongly suggested that it depends on the histological type, as well as the original organ of the cancer. In mucinous ovarian tumors, GnT-V was increased in cancer cells compared to benign and atypical borderline tumor cells.…”

Section: Discussionmentioning

confidence: 66%

High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary

et al. 2009

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Abstract. N-acetylglucosaminyltransferase V (GnT-V) is an enzyme that catalyzes ß1-6 branching of N-acetylglucosamine (GlcNAc) on asparagine-linked oligosaccharides of cell proteins. The present study aimed to investigate GnT-V expression and its prognostic significance in epithelial ovarian cancer. GnT-V expression was studied by immunohistochemistry in 83 surgically resected ovarian cancers, and the staining intensity was evaluated. High GnT-V expression in cancer cells was found in 17 (20.5%) of the 83 cases, and was positively correlated with early FIGO staging. In the histological type, mucinous adenocarcinoma showed significantly strong immunostaining compared to the non-mucinous type (P<0.001). In 36 mucinous tumors, the GnT-V immunostaining score was significantly higher in cancer than in benign and borderline tumors (P<0.001). NOM-1, a human ovarian mucinous adenocarcinoma cell line, expressed strong GnT-V protein and swainsonine treatment suppressed ß1-6GlcNAc branching and reduced migration ability significantly (P<0.001). These results suggested that GnT-V might be involved in the malignant potential of mucinous ovarian cancer.

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“…Upregulated GnT-V activity has been reported in human colon cancer, hepatocarcinoma and breast cancer tissues (6)(7)(8)34). However, increased GnT-V activity has been found to be associated with favorable stages as well as favorable prognosis in non-small cell lung cancers, bladder carcinomas and neuroblastoma (9)(10)(11). In the present study, we investigated the role of GnT-V in gastric cancer during the process of metastasis and invasion.…”

Section: Expression Of Invasion-related Factors In the Bgc823/gnt-v Cmentioning

confidence: 99%

“…In the case of colon cancer and hepatocarcinoma, for instance, high GnT-V expression is associated with a poor prognosis (6)(7)(8). In contrast, low GnT-V levels are linked to a poor prognosis in lung, bladder carcinoma and neuroblastoma patients (9)(10)(11). The role of GnT-V in gastric cancer and its invasive behavior has scarcely been studied.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of the GnT-V gene inhibits metastasis and invasion of BGC823 gastric cancer cells

et al. 2013

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Abstract. Metastatic and invasive potential is a barrier to the successful treatment of gastric cancer. N-acetylglucosaminyltransferase V (GnT-V), a key enzyme catalyzing the formation of 1,6 N-acetylglucosamine (GlcNAc), has been demonstrated to display a distinct function in different types of tumors. The aim of this study was to investigate the role of GnT-V in the invasive potential of BGC823 human gastric cancer cells in vitro and the possible underlying mechanism. GnT-V was downregulated in BGC823 cells by oligo-siRNA transfection. Cell proliferation and invasiveness were assessed by CCK-8 assay, TUNEL assay, scratch-wound assay as well as Transwell assay. The products of GnT-V, β1-6 branching of asparagine-linked oligosaccharides, were determined by L-PHA lectin blot analysis. The expression of EGFRs, E-cadherin/vimentin and MMP-2/MMP-9 was analyzed both at the mRNA and protein levels. The results showed that downregulation of GnT-V decreased proliferation and the metastatic/invasive potential of BGC823 cells. The expression of EGFRs, E-cadherin/vimentin and MMP-9, molecules related to cancer metastasis and invasion in various tumors, were influenced correspondingly. These findings suggest that downregulation of GnT-V inhibited cell metastasis and invasion of BGC823 cells via EGFR signaling-initiated EMT phenotype and MMP-9 expression. These results provide a novel mechanism to explain the role of GnT-V in cell metastasis and invasion.

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High expression of N‐acetylglucosaminyltransferase V in favorable neuroblastomas: Involvement of its effect on apoptosis

Cited by 44 publications

References 24 publications

N-acetylglucosaminyltransferase V inhibits the invasion of trophoblast cells by attenuating MMP2/9 activity in early human pregnancy

N-acetylglucosaminyltransferase V inhibits the invasion of trophoblast cells by attenuating MMP2/9 activity in early human pregnancy

High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary

Downregulation of the GnT-V gene inhibits metastasis and invasion of BGC823 gastric cancer cells

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