High expression of miR-214 is associated with a worse disease-specific survival of the triple-negative breast cancer patients

Abstract

BackgroundHereditary triple-negative breast cancer patients have better recurrence-free survival than triple-negative sporadic ones. High expression of some of the miRNAs is related to worse overall and disease-free survival of triple-negative breast cancer patients. The attempt to associate expression level of some miRNA in triple-negative hereditary and sporadic breast cancers to disease specific survival was performed in this study.Material and methodsStudy group was made of 18 triple-negative breast cancer patients harboring the BRCA1 gene mutations and 32 triple-negative sporadic breast cancer patients. Quantitative amount of mir-10b, mir-21, mir-29a, mir-31, and mir-214 by real-time PCR was assessed. The disease-specific survival in relation of high and low levels of some of the miRNAs was analyzed using Log-rank (Mantel-Cox) test.ResultsMiR-214 showed significantly higher expression level in sporadic tissues than in hereditary ones (p = 0.0005). Triple-negative breast cancer patients with high level of miR-214 showed significantly worse disease-specific survival than patients with low level (p = 0.0314).ConclusionsOur finding suggests that miR-214 possibly could be used as a potential prognostic biomarker for triple-negative breast cancer patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s13053-015-0028-z) contains supplementary material, which is available to authorized users.

Inhibition of miR‑214 attenuates the migration and invasion of triple‑negative breast cancer cells

“…Increasing evidence has demonstrated that miR-214 is aberrantly expressed and its function is altered in various types of tumor; in particular, low miR-214 expression has been detected in liver cancer and ovarian carcinoma (21,33), whereas high miR-214 expression has been observed in BC, gastric cancer and pancreatic cancer (20,24,34). Notably, Kalniete et al (20) detected high expression levels of miR-214 in patients with TNBC. Similar to this previous study, the present data demonstrated that miR-214 was highly expressed in TNBC tissues.…”

MiR-144 suppresses proliferation, invasion, and migration of breast cancer cells through inhibiting CEP55

“…8 For instance, miR-214 is identified to be associated with poor prognosis of the triple-negative breast cancer patients. 9 The up-regulated expression of miR-29c is related to increased survival rate in breast cancer patients. 8 MiR-34 was found to protect breast cancer cells from non-apoptotic cell death.…”

MiRNAs Predict the Prognosis of Patients with Triple Negative Breast Cancer: A Meta-Analysis

“…Recent studies have confirmed that miRNAs are differentially expressed in tissues, blood and urine of cancer patients and healthy individuals, and they are stable in the presence of severe conditions [11]. Therefore, miRNAs are endowed with the characteristics of ideal biomarkers, and some studies have shown that miRNAs correlate with poor cancer prognosis, including TNBC [12–20]. However, the opposite results were obtained in several other studies [21–25].…”