High expression of SDF‑1 and VEGF is associated with poor prognosis in patients with synovial sarcomas

Qi, Feng; Guo, Peng; Wang, Jin; Zhang, Xiaoyu; Yang, Hongjiang; Jin, Feng

doi:10.3892/etm.2018.5684

Cited by 7 publications

(9 citation statements)

References 32 publications

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“…It has been shown in our previous study that SDF-1 was highly expressed in SS tissues, which was also associated with poor prognosis in patients with SS ( 20 ). Notably, SDF-1 was a target gene of miR-126.…”

Section: Discussionmentioning

confidence: 73%

“…It has been shown that HOTAIR can regulate the biological characteristics of gastric cancer cells and glioma cells by binding to and inhibiting microRNA (miR)-126 expression ( 11 , 18 ). On the other hand, stromal cell-derived factor-1 (SDF-1), a target of miR-126 ( 19 ), has been shown to be highly expressed in SS tissues and to be associated with poor prognosis in patients with SS ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

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Long non‑coding RNA HOTAIR promotes the progression of synovial sarcoma through microRNA‑126/stromal cell‑derived factor‑1 regulation

Wang

Guo

et al. 2021

Oncol Lett

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The long non-coding RNA (lncRNA) HOTAIR is an oncogene, that has been reported to be aberrantly expressed in multiple types of malignant tumor tissues. However, its expression and association with synovial sarcoma (SS) remains unclear. The present study aimed to elucidate the expression level of HOTAIR in SS tissues and also identify its role. Reverse transcription-quantitative PCR was used to detect the expression level of HOTAIR and microRNA (miR)-126 in 54 tissue samples from patients with SS, in 10 tissue samples from synovium tissues of normal patients, and in SW982 cells. The protein expression level was measured using western blot analysis and cellular immunofluorescence. Cellular proliferation, invasion and migration were assessed using MTT, Transwell and wound healing assays, respectively. HOTAIR was expressed at high levels in SS tissues. In contrast, miR-126 was expressed at low levels in SS tissues, and was negatively correlated with HOTAIR expression. HOTAIR knockdown in SW982 cells inhibited cellular proliferation in vitro , but also significantly increased the ratio of cells in the G 1 /G 0 phase of the cell cycle, and decreased the ratio of cells in the G 2 /S phase. In addition, HOTAIR knockdown inhibited the invasion and migration of the SW982 cells, as observed in the Transwell and wound healing assays. Furthermore, HOTAIR knockdown increased miR-126 expression level and decreased the expression level of stromal cell-derived factor-1 (SDF-1) at the protein level. On the other hand, while miR-126-mimic decreased the protein expression level of SDF-1, miR-126-inhibitor increased its expression level in SW982 cells. Notably, HOTAIR knockdown or SDF-1 knockout significantly decreased the protein expression levels of CDK1, CDK2, cyclin D1, MMP-9, vimentin and N-cadherin, and significantly increased the protein expression levels of p21, p53 and E-cadherin in SW982 cells. HOTAIR was highly expressed in SS tissues, wherein it could promote the proliferation, invasion and migration of SS cells by increasing the expression of SDF-1 via miR-126 inhibition.

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Long non‑coding RNA HOTAIR promotes the progression of synovial sarcoma through microRNA‑126/stromal cell‑derived factor‑1 regulation

Wang

Guo

et al. 2021

Oncol Lett

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“…Hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and angiopoietins represent key pro-angiogenic signals. Among these signals, VEGF was reported to be over-expressed in several malignancies and it has been well studied as a potential therapeutic target [ 31 , 32 , 33 ]. In MM, VEGF, in addition to HGF, angiopoietins and JunB were up-regulated, where they demonstrated a potential diagnostic and prognostic marker [ 34 , 35 , 36 ].…”

Section: Novel Biomarkers For Diagnosis and Prognosis Of MMmentioning

confidence: 99%

Next-Generation Biomarkers in Multiple Myeloma: Understanding the Molecular Basis for Potential Use in Diagnosis and Prognosis

Soliman

Das

Teoh

2021

IJMS

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Multiple myeloma (MM) is considered to be the second most common blood malignancy and it is characterized by abnormal proliferation and an accumulation of malignant plasma cells in the bone marrow. Although the currently utilized markers in the diagnosis and assessment of MM are showing promising results, the incidence and mortality rate of the disease are still high. Therefore, exploring and developing better diagnostic or prognostic biomarkers have drawn global interest. In the present review, we highlight some of the recently reported and investigated novel biomarkers that have great potentials as diagnostic and/or prognostic tools in MM. These biomarkers include angiogenic markers, miRNAs as well as proteomic and immunological biomarkers. Moreover, we present some of the advanced methodologies that could be utilized in the early and competent diagnosis of MM. The present review also focuses on understanding the molecular concepts and pathways involved in these biomarkers in order to validate and efficiently utilize them. The present review may also help in identifying areas of improvement for better diagnosis and superior outcomes of MM.

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“…Furthermore, the cells migrate to pre-metastatic sites, where they are responsible for the formation of cellular clusters prior to the arrival of tumour cells. In the formation of the pre-metastatic niche, the SDF-1α/CXCR4 axis contributes to the recruitment of endothelial progenitors (EPCs) to the tumour microenvironment [ 10 ]. Altered levels of EPCs can be found in hepatocellular cancer, small-cell cancer, non-small-cell lung cancer, glioma, ovarian cancer, renal cell carcinoma, gastric cancer, colorectal cancer and cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Stromal Cell-Derived Factor 1α (SDF-1α) in Invasive Breast Cancer: Associations with Vasculo-Angiogenic Factors and Prognostic Significance

Zarychta

Ruszkowska-Ciastek

Bielawski

et al. 2021

Cancers

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(1) Background: Tumour angiogenesis is critical for the progression of neoplasms. A prospective study was designed to examine the utility of stromal cell-derived factor 1α (SDF-1α) and selected vasculo-angiogenic parameters for estimating the probability of disease relapse in 84 primary, operable invasive breast cancer (IBrC) patients (40 (48%) with stage IA and 44 (52%) with stage IIA and IIB). (2) Methods: We explored the prognostic value of the plasma levels of SDF-1α, vascular endothelial growth factor A (VEGF-A), the soluble forms of VEGF receptors type 1 and 2, and the number of circulating endothelial progenitor cells (circulating EPCs) in breast cancer patients. The median follow-up duration was 58 months, with complete follow-up for the first event. (3) Results: According to ROC curve analysis, the optimal cut-off point for SDF-1α (for discriminating between patients at high and low risk of relapse) was 42 pg/mL, providing 57% sensitivity and 75% specificity. Kaplan–Meier curves for disease-free survival (DFS) showed that concentrations of SDF-1α lower than 42 pg/dL together with a VEGFR1 lower than 29.86 pg/mL were significantly associated with shorter DFS in IBrC patients (p = 0.0381). Patients with both SDF-1α lower than 42 pg/dL and a number of circulating EPCs lower than 9.68 cells/µL had significantly shorter DFS (p = 0.0138). (4) Conclusions: Our results imply the clinical usefulness of SDF-1α, sVEGFR1 and the number of circulating EPCs as prognostic markers for breast cancer in clinical settings.

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High expression of SDF‑1 and VEGF is associated with poor prognosis in patients with synovial sarcomas

Cited by 7 publications

References 32 publications

Long non‑coding RNA HOTAIR promotes the progression of synovial sarcoma through microRNA‑126/stromal cell‑derived factor‑1 regulation

Long non‑coding RNA HOTAIR promotes the progression of synovial sarcoma through microRNA‑126/stromal cell‑derived factor‑1 regulation

Next-Generation Biomarkers in Multiple Myeloma: Understanding the Molecular Basis for Potential Use in Diagnosis and Prognosis

Stromal Cell-Derived Factor 1α (SDF-1α) in Invasive Breast Cancer: Associations with Vasculo-Angiogenic Factors and Prognostic Significance

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