High‐fat diet feeding alters olfactory‐, social‐, and reward‐related behaviors of mice independent of obesity

Takase, Kenkichi; Tsuneoka, Yousuke; Oda, Satoko; Kuroda, Minpei; Funato, Hiromasa

doi:10.1002/oby.21441

Cited by 76 publications

(80 citation statements)

References 39 publications

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“…Despite the animals in groups P and especially those in group G showing less weight gain after 72 or 182 days treatment, the behavior in EPM was similar to animals in groups C, GL and L. These data match those in the literature when animals were treated with a diet rich in sucrose [5,6], rich in protein [20] and rich in lipids [7,9,10,16] and also showed no change when tested in the EPM. However, the diet rich in lipids had an anxiolytic [13] and anxiogenic effect [11,12,14,15,17].…”

Section: Discussionsupporting

confidence: 87%

“…The assessment of anxiety in animals treated with obesogenic diets (rich in carbohydrates [5,6], lipids [7][8][9][10][11][12][13][14][15][16][17] and carbohydrates and lipids [18,19]) is controversial. For some authors, the diet did not change the behavior in the EPM [5][6][7]9,10,16,20], for others it increased [8,11,12,14,15,[17][18][19] or reduced anxiety [13].…”

Section: Introductionmentioning

confidence: 99%

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Feed restriction since lactation has reduced anxiety in adult Wistar rats

Riul

Almeida

2020

Rev. Nutr.

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Objective To evaluate the effects of macronutrients (protein, carbohydrate and/or lipid) in the diet of young adult (72 days) and adult (182 days) Wistar rats treated ad libitum and with 30% restriction from birth on anxiety in the elevated plus-maze. Methods We used 238 rats treated from birth, composing the groups: Control, Protein, Carbohydrate, Lipid, Carbohydrate and Lipid, Control Restriction, Protein Restriction, Carbohydrate Restriction, Lipid Restriction and Carbohydrate and Lipid Restriction. The animals were weighed at the beginning and at the end of the experiment and tested in the elevated plus-maze. Data were submitted to analysis of variance, followed by the Newman-Keuls Test (p<0.05). Results Among the animals treated ad libitum, the Control, Carbohydrate plus Lipid and Lipid gained more weight than the Carbohydrate and Protein; ad libitum animals gained more weight than those on restriction; among the restrictions, Carbohydrate Restriction rats were the ones that gained less weight. Diet-restricted animals exhibited reduced first-entry latency, greater percentage of entries and time spent, frequency of open arm extremity visits, head dipping (protected and unprotected), and length of stay in the central area of the elevated plus-maze. The animals with 182 days presented greater latency for first entry, reduced frequency of false entries and visits to the ends of the open arms and protected head dipping. Conclusion Food restricted animals, regardless of the macronutrient present in the diet, were less anxious and/or increased their impulsivity and those at 182 days were more anxious and/or with reduced impulsivity.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Feed restriction since lactation has reduced anxiety in adult Wistar rats

Riul

Almeida

2020

Rev. Nutr.

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“…Some observed high alcohol intake in fat-preferring rats, following high-fat diet exposure or injection of dietary lipids (Barson et al, 2009; Carrillo et al, 2004; Krahn and Gosnell, 1991), while others reported no correlation (Prasad et al, 1993) or blunted alcohol intake (Takase et al, 2016). However, to our knowledge, this is the first examination of alcohol intake following prolonged episodes of binge-like feeding of a nutritionally complete high-fat diet.…”

Section: 0 Discussionmentioning

confidence: 99%

Intermittent access to a nutritionally complete high-fat diet attenuates alcohol drinking in rats

Sirohi

Cleef

Davis

2017

Pharmacology Biochemistry and Behavior

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Binge eating disorder and alcohol use disorder (AUD) frequently co-occur in the presence of other psychiatric conditions. Data suggest that binge eating engages similar behavioral and neurochemical processes common to AUD, which might contribute to the etiology or maintenance of alcoholism. However, it is unclear how binge feeding behavior and alcohol intake interact to promote initiation or maintenance of AUD. We investigated the impact of binge-like feeding on alcohol intake and anxiety-like behavior in male Long Evans rats. Rats received chow (controls) or extended intermittent access (24 hr twice a week; Int-HFD) to a nutritionally complete high-fat diet for six weeks. Standard rodent chow was available ad-libitum to all groups and food intake was measured. Following HFD exposure, 20.0% ethanol, 2.0% sucrose intake and endocrine peptide levels were evaluated. Anxiety-like behavior was measured using a light-dark (LD) box apparatus. Rats in the Int-HFD group displayed a binge-like pattern of feeding (alternations between caloric overconsumption and voluntary caloric restriction). Surprisingly, alcohol intake was significantly attenuated in the Int-HFD group whereas sugar consumption was unaffected. Plasma acyl-ghrelin levels were significantly elevated in the Int-HFD group, whereas glucagon-like peptide-1 levels did not change. Moreover, rats in the Int-HFD group spent more time in the light side of the LD box compared to controls, indicating that binge-like feeding induced anxiolytic effects. Collectively, these data suggest that intermittent access to HFD attenuates alcohol intake through reducing anxiety-like behavior, a process potentially controlled by elevated plasma ghrelin levels.

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“…High-fat diet (HFD) consumption is associated with cognitive impairment, increased aggression and altered social- and reward-related behaviors in mice (Hilakivi-Clarke et al, 1996; Pistell et al, 2010; Takase et al, 2016). A mouse model of n-3 polyunsaturated fatty acids (PUFAs) deficiency resulted in defective spatial learning and memory tasks, with increased depressive-like behavior (Larrieu et al, 2012; Moranis et al, 2012).…”

Section: Microglial Perturbations During Brain Developmentmentioning

confidence: 99%

Function and Dysfunction of Microglia during Brain Development: Consequences for Synapses and Neural Circuits

Paolicelli

Ferretti

2017

Front. Synaptic Neurosci.

164

126

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Many diverse factors, ranging from stress to infections, can perturb brain homeostasis and alter the physiological activity of microglia, the immune cells of the central nervous system. Microglia play critical roles in the process of synaptic maturation and brain wiring during development. Any perturbation affecting microglial physiological function during critical developmental periods could result in defective maturation of synaptic circuits. In this review, we critically appraise the recent literature on the alterations of microglial activity induced by environmental and genetic factors occurring at pre- and early post-natal stages. Furthermore, we discuss the long-lasting consequences of early-life microglial perturbation on synaptic function and on vulnerability to neurodevelopmental and psychiatric disorders.

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High‐fat diet feeding alters olfactory‐, social‐, and reward‐related behaviors of mice independent of obesity

Cited by 76 publications

References 39 publications

Feed restriction since lactation has reduced anxiety in adult Wistar rats

Feed restriction since lactation has reduced anxiety in adult Wistar rats

Intermittent access to a nutritionally complete high-fat diet attenuates alcohol drinking in rats

Function and Dysfunction of Microglia during Brain Development: Consequences for Synapses and Neural Circuits

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