2021
DOI: 10.1186/s13062-021-00294-7
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High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma

Abstract: Background Long-chain acyl-CoA synthetase-4 (ACSL4) is involved in fatty acid metabolism, and aberrant ACSL4 expression could be either tumorigenic or tumor-suppressive in different tumor types. However, the function and clinical significance of ACSL4 in lung adenocarcinoma remain elusive. Results ACSL4 was frequently downregulated in lung adenocarcinoma when analyzing both the TCGA database and the validation samples, and the lower ACSL4 expressio… Show more

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Cited by 53 publications
(38 citation statements)
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“…Ferroptosis is associated to an iron-dependent peroxidation of membrane lipids [ 33 ] and can be triggered by GSH depletion or by direct inactivation of GPX4 [ 34 37 ], both involved in reduction of peroxidic species of polyunsaturated fatty acids. p53 has been implicated in both activation/inhibition of this cell death modality.…”
Section: P53 In Ferroptotic Cell Deathmentioning
confidence: 99%
“…Ferroptosis is associated to an iron-dependent peroxidation of membrane lipids [ 33 ] and can be triggered by GSH depletion or by direct inactivation of GPX4 [ 34 37 ], both involved in reduction of peroxidic species of polyunsaturated fatty acids. p53 has been implicated in both activation/inhibition of this cell death modality.…”
Section: P53 In Ferroptotic Cell Deathmentioning
confidence: 99%
“…Ferroptosis is a new iron-dependent form of regulated cell death,which characterized by iron-dependent accumulation of lipid-ROS and subsequent depletion of polyunsaturated fatty acid phospholipids (PUFA-PLS) ( Hirschhorn and Stockwell, 2019 ). ACSL4 has been shown to be overexpressed in several cancer types, including colon cancer, breast cancer, liver and prostate cancer ( Sánchez-Martínez et al, 2017 ; Wang J. et al, 2020 ; Chen et al, 2020 ; Ma et al, 2021 ; Sha et al, 2021 ), but often down-regulated in gastric cancer and lung cancer ( Ye et al, 2016 ; Zhang et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%
“…The SLC7A11-GSH-GPX4 signaling axis constitutes the major surveillance system to defend against ferroptosis in cancer cells ( Koppula et al, 2022 ). SLC7A11 and GPX4 are considered as the central regulators of ferroptosis, and SLC7A11 expression and GPX4 activity are always regarded as markers of ferroptosis ( Liu P. et al, 2020 ; Zhang et al, 2021b ; Yuan et al, 2021 ). GPX4 is on the downstream of SLC7A11, utilizing GSH to detoxify lipid peroxides and prevent ferroptosis.…”
Section: Introductionmentioning
confidence: 99%