High Fat Diets Composed of Palm Stearin and Olive Oil Equally Exacerbate Liver Inflammatory Damage and Metabolic Stress in Mice

Meidan, Elena; Kolesnikov, Yula; Tirosh, Oren

doi:10.1002/mnfr.201700915

Cited by 12 publications

(10 citation statements)

References 45 publications

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“…Similar results were received in the study that examined high-fat diets composed of palm stearin and OO in mice. Both diets equally exacerbated liver inflammatory damage and metabolic stress (44). It seems that as long as fat is consumed in moderation, oil types may play a lesser role in the metabolism of healthy individuals.…”

Section: Discussionmentioning

confidence: 97%

Effect of dietary oils from various sources on carbohydrate and fat metabolism in mice

Altberg

Hovav

Chapnik

et al. 2020

Food & Nutrition Research

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Background: Dietary oils differ in their fatty acid composition and the presence of additional microcomponents (antioxidants, etc.). These differences are thought to invoke different biochemical pathways, thus affecting fats and carbohydrates metabolism differently. Olive oil (OO) and soybean oil (SO) are common vegetable oils in the local cuisine. Peanuts oils of local varieties are viewed as potential sources of dietary vegetable oils, especially in the food industry. Objective: We examined the effect of four different dietary vegetable oils on carbohydrate and lipid metabolism in mice. The selected oils were OO, high in oleic acid, extracted from cultivated high oleic acid peanut (C-PO), regular peanut oil (PO), and SO. Design: In this study, 32 male C57BL/6J mice were randomly divided into four groups (n = 8 in each group) and were fed with four different diets enriched with 4% (w/w) dietary vegetable oils (OO, C-PO, PO, or SO). After 10 weeks, the mice were sacrificed. Western blot was used to examine proteins such as phospho-AMP-activated protein kinase (p-AMPK), ace-tyl-CoA carboxylase (ACC), cluster of differentiation 36 (CD36), and Sirtuin 1 (SIRT1), whereas real-time polymerase chain reaction (PCR) was used to examine the expression of sterol regulatory element-binding protein-1c (SREBP-1C), fatty acid synthase (FAS), glucose-6-phosphatase (G6Pase), and CD36 transcripts. Results: In mice-fed SO, lipid accumulation was predominately in adipose tissue, accompanied a tendency decrease in insulin sensitivity. Mice-fed OO had lower plasma triglycerides (TG) and increased hepatic CD36 gene expression. The C-PO group presented lower messenger RNA (mRNA) levels in the liver for all examined genes: SREBP-1c, FAS, G6Pase, and CD36. There were no significant differences in weight gain, plasma cholesterol and high-density lipoprotein (HDL) cholesterol levels, hepatic ACC, SIRT1, AMPK, and CD36 protein levels or in liver function among the diets. Discussion: It seems that as long as fat is consumed in moderation, oil types may play a lesser role in the metabolism of healthy individuals. Conclusion: This finding has the potential to increase flexibility in choosing oil types for consumption.

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Section: Discussionmentioning

confidence: 97%

Effect of dietary oils from various sources on carbohydrate and fat metabolism in mice

Altberg

Hovav

Chapnik

et al. 2020

Food & Nutrition Research

View full text Add to dashboard Cite

show abstract

“…Interestingly, blood glucose and triglyceride (TG) levels were reduced in animals receiving the oil gavage and LPS compared to acute individual treatments. In contrast, serum FFAs were significantly elevated in groups given olive oil and LPS [140]. Taken together, these findings conclude that HFDs of either MUFAs or SFAs may potentiate LPS-induced liver inflammation and hyperinsulinemia, perhaps by the induction of lipolysis and a subsequent increase in FFA flux, and that total fat content rather than type is a driver of inflammation.…”

Section: Lps Inflammation and Dietary Lipidsmentioning

confidence: 98%

“…Given the potent proinflammatory effects of SFAs, much emphasis has been placed on the Mediterranean diet as a healthful alternative due to its high content of monounsaturated fatty acids (MUFAs) primarily from olive oil [139]. In stark contrast to this notion however, the recent findings of Meidan and colleagues suggest that olive oil may exacerbate liver inflammatory damage [140]. Six-week-old C57BL/6J male mice were fed a 60% HFD for 8 weeks containing palm stearin (PS) or olive oil, as well as a low 16% fat diet.…”

Section: Lps Inflammation and Dietary Lipidsmentioning

confidence: 99%

“…Following the 8 weeks dietary intervention, animals were fasted for 12 h, treated with a single intraperitoneal injection of LPS and sacrificed 6 h thereafter. Although LPS treatment resulted in a trend of losing fat in the liver and hypoglycemia in all diet groups, plasma hepatic enzyme (SGPT, ALT and SGOT, AST) and insulin levels were significantly elevated in both high-fat groups injected with LPS; LPS had no effect on the low-fat diet group and no significant differences were observed between both HFD groups given LPS [140]. Combined treatment of LPS with both HFDs suppressed gluconeogenesis as well.…”

Section: Lps Inflammation and Dietary Lipidsmentioning

confidence: 99%

“…In addition to the dietary intervention, a fatty acid loading-gavage feeding protocol was implemented using 5–6 weeks old male C57BL/6J mice consuming a standard chow diet. Mice were force fed olive oil via gavage, and/or injected with LPS following an overnight fast and sacrificed 6 h thereafter [140]. Interestingly, blood glucose and triglyceride (TG) levels were reduced in animals receiving the oil gavage and LPS compared to acute individual treatments.…”

Section: Lps Inflammation and Dietary Lipidsmentioning

confidence: 99%

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Role of Dietary Lipids in Modulating Inflammation through the Gut Microbiota

2019

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Inflammation and its resolution is a tenuous balance that is under constant contest. Though several regulatory mechanisms are employed to maintain homeostasis, disruptions in the regulation of inflammation can lead to detrimental effects for the host. Of note, the gut and microbial dysbiosis are implicated in the pathology of systemic chronic low-grade inflammation which has been linked to several metabolic diseases. What remains to be described is the extent to which dietary fat and concomitant changes in the gut microbiota contribute to, or arise from, the onset of metabolic disorders. The present review will highlight the role of microorganisms in host energy regulation and several mechanisms that contribute to inflammatory pathways. This review will also discuss the immunomodulatory effects of the endocannabinoid system and its link with the gut microbiota. Finally, a brief discussion arguing for improved taxonomic resolution (at the species and strain level) is needed to deepen our current knowledge of the microbiota and host inflammatory state.

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High dietary intake of palm oils compromises glucose tolerance whereas high dietary intake of olive oil compromises liver lipid metabolism and integrity

et al. 2018

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High Fat Diets Composed of Palm Stearin and Olive Oil Equally Exacerbate Liver Inflammatory Damage and Metabolic Stress in Mice

Abstract: HFDs of both monounsaturated and saturated fat potentiated liver inflammation induced by LPS treatment indicate that the total amount of fat consumed is the main proinflammatory factor rather than the type of fat.

Cited by 12 publications

References 45 publications

Effect of dietary oils from various sources on carbohydrate and fat metabolism in mice

Effect of dietary oils from various sources on carbohydrate and fat metabolism in mice

Role of Dietary Lipids in Modulating Inflammation through the Gut Microbiota

High dietary intake of palm oils compromises glucose tolerance whereas high dietary intake of olive oil compromises liver lipid metabolism and integrity

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